INT92399

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.59
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
nucleus 4
paw 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.00 Very High Very High Very High
Inflammation 16 92.84 High High
dexamethasone 2 91.24 High High
fluoxetine 2 87.20 High High
Serotonin 1 86.00 High High
Desipramine 2 85.28 High High
Endep 3 84.64 Quite High
tricyclic antidepressant 1 83.84 Quite High
Antinociceptive 2 83.04 Quite High
cINOD 6 77.32 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 97.56 Very High Very High Very High
INFLAMMATION 12 92.84 High High
Pheochromocytoma 1 91.68 High High
Death 5 89.00 High High
Glioma 2 75.00 Quite High
Disease 2 64.48 Quite High
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Positive_regulation (zymosan-induced) of Transcription (transcription) of NF-kB-dependent in nucleus associated with spinal cord
1) Confidence 0.49 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.46 Pain Relevance 0.50
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Positive_regulation (zymosan-induced) of Transcription (transcription) of NF-kB in nucleus associated with spinal cord
2) Confidence 0.49 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.47 Pain Relevance 0.53
Furthermore, luciferase reporter assays showed that gamma-mangostin reduced the LPS-inducible activation of NF-kappaB-and human COX-2 gene promoter region-dependent transcription. gamma-Mangostin also inhibited rat carrageenan-induced paw edema.
Positive_regulation (activation) of Transcription (transcription) of NF-kappaB-and in paw associated with pressure and volume under development
3) Confidence 0.26 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.17 Pain Relevance 0.08
Here, we show that these neurotoxic effects are accompanied by a selective activation of extracellular signal-regulated protein kinase (ERK), the biosynthesis of the transcription factor Egr-1 and an increase in the transcriptional activity of NF-kappa B.
Positive_regulation (increase) of Transcription (activity) of NF-kappa B
4) Confidence 0.03 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11996893 Disease Relevance 0.49 Pain Relevance 0.36

General Comments

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