INT924

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 1.40
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 10
gland 4
body 4
anterior pituitary 2
pituitary gland 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 31 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
agonist 28 99.66 Very High Very High Very High
Opioid 10 99.30 Very High Very High Very High
Neuropeptide 3 96.44 Very High Very High Very High
withdrawal 10 96.08 Very High Very High Very High
Endogenous opioid 4 91.84 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 12 98.64 Very High Very High Very High
Hypertension 2 95.04 Very High Very High Very High
Galactorrhea 1 74.96 Quite High
Hypoglycemia 1 74.36 Quite High
Increased Venous Pressure Under Development 1 69.40 Quite High
Anovulation 8 68.16 Quite High
Disease 7 65.68 Quite High
Ulcers 2 65.36 Quite High
Endometriosis (extended) 59 65.20 Quite High
Gynecomastia 1 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the lower level fluctuation of baseline endogenous FSH secretion may not affect the result of pharmacokinetic analysis in the present study.
Neg (not) Spec (may) Regulation (affect) of Localization (secretion) of FSH
1) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Pretreatment of the volunteers with the narcotic antagonist, naloxone, failed to alter the postexercise or LRH-stimulated LH and FSH release.
Neg (failed) Regulation (alter) of Localization (release) of FSH associated with antagonist and narcan
2) Confidence 0.31 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.20
They possess similar alpha but different specific beta subunits.18,19 The nomenclature “alpha” differentiates it from another recombinant human FSH product which was marketed later as follitropin beta.20

Isoforms

Regulation (later) of Localization (marketed) of FSH product
3) Confidence 0.30 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0
Cimetidine had no effect on the GH, PRL, or cortisol response to insulin-induced hypolycemia or the 24-h secretion of LH, FSH, testosterone, or PRL.
Neg (no) Regulation (effect) of Localization (secretion) of FSH
4) Confidence 0.20 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 113425 Disease Relevance 0.38 Pain Relevance 0.13
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion prior to and during the gonadotrophin surge were not affected by naloxone (0.33 mg/kg body wt per h) administered from the time of medroxyprogesterone acetate withdrawal until 30 h after the onset of oestrus (n = 6).
Neg (not) Regulation (affected) of Localization (secretion) of FSH in body associated with narcan and withdrawal
5) Confidence 0.17 Published 1991 Journal J. Reprod. Fertil. Section Abstract Doc Link 1909367 Disease Relevance 0 Pain Relevance 0.76
As the number of immature follicles declines with age, negative feedback control on FSH secretion is relaxed, and basal circulating levels of FSH rise.
Regulation (control) of Localization (secretion) of FSH in follicles
6) Confidence 0.15 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.17 Pain Relevance 0
The increase in circulating plasma FSH levels appears to be due mainly to reduced secretion of follicular growth and differentiation factors related to transforming growth factor-b that negatively affect the release of FSH from the pituitary gland.
Regulation (affect) of Localization (release) of FSH in pituitary gland
7) Confidence 0.15 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.19 Pain Relevance 0
Since the angiotensin converting enzyme can participate in the metabolism of opioid peptides, this study examined the action of Captopril, an angiotensin converting enzyme inhibitor, on corticotropin and gonadotropin (LH and FSH) release induced by the opiate antagonist naloxone in man.
Spec (examined) Regulation (action) of Localization (release) of FSH associated with antagonist, narcan, opiate and opioid
8) Confidence 0.14 Published 1993 Journal Horm. Metab. Res. Section Abstract Doc Link 8262463 Disease Relevance 0.10 Pain Relevance 0.72
None of the opiate agonists employed had an effect on FSH secretion.
Regulation (effect) of Localization (secretion) of FSH associated with agonist and opiate
9) Confidence 0.14 Published 1983 Journal Peptides Section Abstract Doc Link 6318200 Disease Relevance 0 Pain Relevance 0.82
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion prior to and during the gonadotrophin surge were not affected by naloxone (0.33 mg/kg body wt per h) administered from the time of medroxyprogesterone acetate withdrawal until 30 h after the onset of oestrus (n = 6).
Neg (not) Regulation (affected) of Localization (secretion) of follicle-stimulating hormone in body associated with narcan and withdrawal
10) Confidence 0.13 Published 1991 Journal J. Reprod. Fertil. Section Abstract Doc Link 1909367 Disease Relevance 0 Pain Relevance 0.76
Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH (Gonadotropin-releasing hormone, also known as Luteinizing-Hormone-Releasing Hormone or LHRH), the latter responsible for the release of FSH and LH from the anterior pituitary.
Regulation (responsible) of Localization (release) of FSH in anterior pituitary associated with neuropeptide
11) Confidence 0.06 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2992060 Disease Relevance 0.07 Pain Relevance 0.09
Differential regulation of LH and follicle-stimulating hormone (FSH) secretion is evident during lactation, probably as a consequence of ovarian inhibitory, inhibin-mediated control of FSH but not of LH secretion.
Regulation (regulation) of Localization (secretion) of follicle-stimulating hormone in follicle
12) Confidence 0.04 Published 1992 Journal J. Reprod. Fertil. Suppl. Section Abstract Doc Link 1304026 Disease Relevance 0 Pain Relevance 0.28
Opioidergic control of gonadotropin secretion in the female rabbit: divergent effects of morphine on secretion of follicle-stimulating hormone and luteinizing hormone.
Regulation (effects) of Localization (secretion) of follicle-stimulating hormone in follicle associated with morphine
13) Confidence 0.04 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 2516768 Disease Relevance 0 Pain Relevance 0.37
A contraceptive approach being developed is based on analogs of the hypothalamic hormone controlling secretion of both the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) from the anterior pituitary gland.
Regulation (controlling) of Localization (secretion) of FSH in gland
14) Confidence 0.03 Published 1983 Journal Res Front Fertil Regul Section Abstract Doc Link 12179624 Disease Relevance 0 Pain Relevance 0.03
A contraceptive approach being developed is based on analogs of the hypothalamic hormone controlling secretion of both the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) from the anterior pituitary gland.
Regulation (controlling) of Localization (secretion) of follicle stimulating hormone in gland
15) Confidence 0.03 Published 1983 Journal Res Front Fertil Regul Section Abstract Doc Link 12179624 Disease Relevance 0 Pain Relevance 0.03
Effect of antagonists of dopamine and opiates on the basal and GnRH-induced secretion of luteinizing hormone, follicle stimulating hormone and prolactin during lactational amenorrhoea in breastfeeding women.
Regulation (Effect) of Localization (secretion) of stimulating hormone in follicle associated with dopamine, antagonist, narcan, opiate and reprotox - general 1
16) Confidence 0.03 Published 1993 Journal Hum. Reprod. Section Title Doc Link 8501180 Disease Relevance 0.19 Pain Relevance 0.60
The increase in prolactin level is probably not directly involved in normal secretion of LH and follicle stimulating hormone (FSH) at ovulation.
Neg (not) Regulation (involved) of Localization (secretion) of stimulating hormone in follicle
17) Confidence 0.01 Published 1980 Journal J. Reprod. Fertil. Section Abstract Doc Link 6776267 Disease Relevance 0.31 Pain Relevance 0.26

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