INT92402

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.75
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
nucleus 4
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 19 99.68 Very High Very High Very High
Spinal cord 2 99.00 Very High Very High Very High
cINOD 13 98.78 Very High Very High Very High
dexamethasone 2 92.24 High High
Antinociceptive 2 84.04 Quite High
aspirin 2 71.96 Quite High
Inflammatory mediators 1 46.56 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 99.68 Very High Very High Very High
Apoptosis 2 95.16 Very High Very High Very High
Repression 1 90.88 High High
Colon Cancer 2 78.96 Quite High
Disease 2 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kB-dependent in nucleus associated with spinal cord
1) Confidence 0.42 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.47 Pain Relevance 0.53
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kB in nucleus associated with spinal cord
2) Confidence 0.42 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.47 Pain Relevance 0.53
There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely by inhibiting the function of nuclear factor kappaB (NFkappaB) and consequently the transcription of pro-inflammatory genes.
Negative_regulation (inhibiting) of Transcription (transcription) of NFkappaB associated with inflammation
3) Confidence 0.33 Published 2007 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 17561338 Disease Relevance 0.33 Pain Relevance 0.16
Finally, we demonstrate that NSAID-mediated nucleolar translocation of RelA is associated with downregulation of NF-kappaB-driven transcription and of the NF-kappaB target gene, ICAM-1.
Negative_regulation (downregulation) of Transcription (transcription) of NF-kappaB associated with cinod
4) Confidence 0.09 Published 2008 Journal Oncogene Section Abstract Doc Link 18059344 Disease Relevance 0.47 Pain Relevance 0.54

General Comments

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