INT92405

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.52
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Slc22a6) plasma membrane (Slc22a6) protein complex (Slc22a6)
Slc22a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 99.26 Very High Very High Very High
methotrexate 12 96.40 Very High Very High Very High
cINOD 8 95.84 Very High Very High Very High
aspirin 2 94.16 High High
vincristine 2 82.84 Quite High
Bile 2 47.28 Quite Low
Morphine 10 5.00 Very Low Very Low Very Low
Patient controlled alalgesia 4 5.00 Very Low Very Low Very Low
Codeine 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 99.26 Very High Very High Very High
Injury 184 99.02 Very High Very High Very High
INFLAMMATION 8 95.12 Very High Very High Very High
Toxicity 3 76.20 Quite High
Renal Disease 12 26.96 Quite Low
Heart Rate Under Development 2 5.56 Low Low
Chronic Renal Failure 16 5.00 Very Low Very Low Very Low
Critical Illness 14 5.00 Very Low Very Low Very Low
Uremia 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Dixon plots showed that probenecid, indomethacin and salicylate competitively inhibited rOAT1 with apparent K(i) values of 15.8 microM, 4.2 microM and 1.0 mM, respectively.
Negative_regulation (inhibited) of rOAT1
1) Confidence 0.47 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11099697 Disease Relevance 0.23 Pain Relevance 0.78
Although the role played by OATs in nonrenal drug clearance has not been characterized, decreased OAT1 and OAT3 activity as a result of AKI could decrease the renal secretion of drugs such as methotrexate, nonsteroidal anti-inflammatory drugs, and acetylsalicylic acid [16].
Negative_regulation (decreased) of OAT1 associated with aspirin, inflammation, injury, cinod and methotrexate
2) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.72 Pain Relevance 0.30
Induction of AKI in ischemia-reperfusion rat models demonstrates decreased OAT1 and OAT3 mRNA as well as protein expression [34-36].
Negative_regulation (decreased) of OAT1 associated with ischemia and injury
3) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.56 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox