INT9243

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Context Info
Confidence 0.53
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.52
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOXG1) DNA binding (FOXG1) transcription factor binding (FOXG1)
Anatomy Link Frequency
telencephalic 2
skin 1
lung 1
neural 1
hindbrain 1
FOXG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 2 99.52 Very High Very High Very High
Spinal cord 22 99.28 Very High Very High Very High
midbrain 28 98.60 Very High Very High Very High
Central nervous system 14 94.32 High High
Pain 71 93.36 High High
ischemia 1 70.16 Quite High
Dopamine 18 64.48 Quite High
Glutamate 18 56.48 Quite High
gABA 18 55.04 Quite High
Inflammation 14 52.64 Quite High
Disease Link Frequency Relevance Heat
Thalassemia 464 99.48 Very High Very High Very High
Hemolysis 186 98.86 Very High Very High Very High
Hypertension 50 98.68 Very High Very High Very High
Lung Injury 7 98.00 Very High Very High Very High
Reprotox - General 2 37 97.64 Very High Very High Very High
Injury 4 97.48 Very High Very High Very High
Toxicity 7 96.92 Very High Very High Very High
Sickle Cell Anemia 138 94.68 High High
Adhesions 3 94.64 High High
Disease 85 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the telencephalic transcription factor FOXG128 was detected in the NE cells by RT-PCR at day 17 of differentiation (Figure 3B) and by immunostaining at day 25 of differentiation (Figure 3D).
Gene_expression (Expression) of FOXG128 in telencephalic
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
Increased HbF production was associated with demethylation of two restriction enzyme sites 5' to the two gamma-globin genes.
Gene_expression (production) of HbF
2) Confidence 0.42 Published 1983 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 6198661 Disease Relevance 0.25 Pain Relevance 0.09
The generation of the region-specific neural cells positive for FOXG1, OTX2 or HOXB4 was comparable between TZ1 and YZ1 hiPSC, and H9 hESC.
Gene_expression (generation) of FOXG1 in neural
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0.10
Mature neural progenitors weakly express telencephalic markers, but strong expression of BF1, EN2 and OTX2 but not EN1 reveals their forebrain character.
Gene_expression (expression) of BF1 in telencephalic
4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.14
Based on these results, we suggest that noxious mechanical stimulation of the skin produces changes of HBF, either as a reflex response via activation of the hepatic sympathetic nerves or as a passive response to systemic circulatory changes, depending on the sites stimulated.
Gene_expression (produces) of HBF in skin
5) Confidence 0.37 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12171255 Disease Relevance 0.09 Pain Relevance 0.09
Interestingly, at D42 the cells expressed the ventral diencephalon marker RX, telencephalic marker BF1 [20], [21], as well as the hindbrain marker GBX2 (Figure 4E).
Gene_expression (expressed) of BF1 in hindbrain
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.15
In this study, higher HbF and fewer vascular complications were found in the low LDH groups.
Gene_expression (found) of HbF
7) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.51 Pain Relevance 0.16
This group also had lower hemoglobin concentrations, serum arginine, arginine to ornithine ratios, and fetal hemoglobin (HbF) levels.
Gene_expression (levels) of HbF
8) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.62 Pain Relevance 0
Nevertheless, the degree of hemolysis varies among patients and its intensity is modulated by HbF expression and co-incident ?
Gene_expression (expression) of HbF associated with hemolysis
9) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.45 Pain Relevance 0.06
Levels of HBF, HO2D, and MEGX were measured at BASELINE, after lung injury (INJURY time point), and after addition of PEEP (PEEP time point).
Gene_expression (Levels) of HBF in lung associated with lung injury and injury
10) Confidence 0.13 Published 1992 Journal J Trauma Section Abstract Doc Link 1404522 Disease Relevance 0.67 Pain Relevance 0.21
thalassemia and/or a gene for raised HbF production (XmnI polymorphism).
Gene_expression (production) of HbF associated with thalassemia
11) Confidence 0.09 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 0.91 Pain Relevance 0
These factors are the presence of silent or mild beta-thalassemia alleles associated with a high residual output of beta globin, the co-inheritance of alpha thalassemia and/or of genetic determinants able to sustain a continuous production of gamma globin chains (HbF) in adult life [18].
Gene_expression (production) of HbF associated with thalassemia
12) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 0.90 Pain Relevance 0
Other mutations increasing HbF production are those associated with deletional and non-deletional HPFH linked to the beta globin gene cluster.
Gene_expression (production) of HbF
13) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 0.78 Pain Relevance 0
The hemoglobin (Hb) profile and HbF levels were investigated by high performance liquid chromatography (HPLC/VARIANT I; BIO-RAD, CA, USA).


Gene_expression (levels) of HbF
14) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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