INT9243

Context Info Confidence 0.53 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 14 Total Number 14 Disease Relevance 7.52 Pain Relevance 1.02

nucleus (FOXG1) DNA binding (FOXG1) transcription factor binding (FOXG1)

Anatomy Link Frequency telencephalic 2 skin 1 lung 1 neural 1 hindbrain 1 FOXG1 (Homo sapiens)

Pain Link Frequency Relevance Heat lidocaine 2 99.52 Spinal cord 22 99.28 midbrain 28 98.60 Central nervous system 14 94.32 Pain 71 93.36 ischemia 1 70.16 Dopamine 18 64.48 Glutamate 18 56.48 gABA 18 55.04 Inflammation 14 52.64

Disease Link Frequency Relevance Heat Thalassemia 464 99.48 Hemolysis 186 98.86 Hypertension 50 98.68 Lung Injury 7 98.00 Reprotox - General 2 37 97.64 Injury 4 97.48 Toxicity 7 96.92 Sickle Cell Anemia 138 94.68 Adhesions 3 94.64 Disease 85 91.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of the telencephalic transcription factor FOXG128 was detected in the NE cells by RT-PCR at day 17 of differentiation (Figure 3B) and by immunostaining at day 25 of differentiation (Figure 3D).

Gene_expression (Expression) of FOXG128 in telencephalic

1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0

Increased HbF production was associated with demethylation of two restriction enzyme sites 5' to the two gamma-globin genes.

Gene_expression (production) of HbF

2) Confidence 0.42 Published 1983 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 6198661 Disease Relevance 0.25 Pain Relevance 0.09

The generation of the region-specific neural cells positive for FOXG1, OTX2 or HOXB4 was comparable between TZ1 and YZ1 hiPSC, and H9 hESC.

Gene_expression (generation) of FOXG1 in neural

3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0.10

Mature neural progenitors weakly express telencephalic markers, but strong expression of BF1, EN2 and OTX2 but not EN1 reveals their forebrain character.

Gene_expression (expression) of BF1 in telencephalic

4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.14

Based on these results, we suggest that noxious mechanical stimulation of the skin produces changes of HBF, either as a reflex response via activation of the hepatic sympathetic nerves or as a passive response to systemic circulatory changes, depending on the sites stimulated.

Gene_expression (produces) of HBF in skin

5) Confidence 0.37 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12171255 Disease Relevance 0.09 Pain Relevance 0.09

Interestingly, at D42 the cells expressed the ventral diencephalon marker RX, telencephalic marker BF1 [20], [21], as well as the hindbrain marker GBX2 (Figure 4E).

Gene_expression (expressed) of BF1 in hindbrain

6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.15

In this study, higher HbF and fewer vascular complications were found in the low LDH groups.

Gene_expression (found) of HbF

7) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.51 Pain Relevance 0.16

This group also had lower hemoglobin concentrations, serum arginine, arginine to ornithine ratios, and fetal hemoglobin (HbF) levels.

Gene_expression (levels) of HbF

8) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.62 Pain Relevance 0

Nevertheless, the degree of hemolysis varies among patients and its intensity is modulated by HbF expression and co-incident ?

Gene_expression (expression) of HbF associated with hemolysis

9) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.45 Pain Relevance 0.06

Levels of HBF, HO2D, and MEGX were measured at BASELINE, after lung injury (INJURY time point), and after addition of PEEP (PEEP time point).

Gene_expression (Levels) of HBF in lung associated with lung injury and injury

10) Confidence 0.13 Published 1992 Journal J Trauma Section Abstract Doc Link 1404522 Disease Relevance 0.67 Pain Relevance 0.21

thalassemia and/or a gene for raised HbF production (XmnI polymorphism).

Gene_expression (production) of HbF associated with thalassemia

11) Confidence 0.09 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 0.91 Pain Relevance 0

These factors are the presence of silent or mild beta-thalassemia alleles associated with a high residual output of beta globin, the co-inheritance of alpha thalassemia and/or of genetic determinants able to sustain a continuous production of gamma globin chains (HbF) in adult life [18].

Gene_expression (production) of HbF associated with thalassemia

12) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 0.90 Pain Relevance 0

Other mutations increasing HbF production are those associated with deletional and non-deletional HPFH linked to the beta globin gene cluster.

Gene_expression (production) of HbF

13) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 0.78 Pain Relevance 0

The hemoglobin (Hb) profile and HbF levels were investigated by high performance liquid chromatography (HPLC/VARIANT I; BIO-RAD, CA, USA).

Gene_expression (levels) of HbF

14) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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