INT92434

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 287
Total Number 291
Disease Relevance 91.65
Pain Relevance 83.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
neurons 10
spinal 8
Neuro-2a 6
dorsal horn 6
hepatocytes 5
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 656 100.00 Very High Very High Very High
nMDA receptor 402 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
bradykinin 11 99.96 Very High Very High Very High
fluoxetine 46 99.92 Very High Very High Very High
dorsal root ganglion 201 99.86 Very High Very High Very High
Opioid 263 99.84 Very High Very High Very High
Nucleus accumbens 184 99.84 Very High Very High Very High
IPN 54 99.84 Very High Very High Very High
Inflammation 1256 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 382 100.00 Very High Very High Very High
Ganglion Cysts 289 99.86 Very High Very High Very High
Aging 811 99.84 Very High Very High Very High
Inflammatory Pain 111 99.84 Very High Very High Very High
INFLAMMATION 1360 99.82 Very High Very High Very High
Nervous System Injury 276 99.82 Very High Very High Very High
Neuropathic Pain 320 99.76 Very High Very High Very High
Apoptosis 694 99.66 Very High Very High Very High
Appetite Loss 140 99.64 Very High Very High Very High
Nociception 408 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All drugs of abuse increased ERK phosphorylation in nucleus accumbens, lateral bed nucleus of the stria terminalis, central amygdala and deep layers of prefrontal cortex, through a dopamine D1 receptor-dependent mechanism.
Phosphorylation (phosphorylation) of ERK in prefrontal associated with nucleus accumbens, dopamine and amygdala
1) Confidence 0.82 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.70
The upstream inhibitor of ERK phosphorylation, U0126 (100-400 microg/kg, i.v., 10 min pre-capsaicin), dose-dependently inhibited referred hyperalgesia 3-6 h after capsaicin.
Phosphorylation (phosphorylation) of ERK associated with hyperalgesia and qutenza
2) Confidence 0.81 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941468 Disease Relevance 0.58 Pain Relevance 1.30
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Phosphorylation (phosphorylated) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
3) Confidence 0.81 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.25
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Phosphorylation (phosphorylated) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
4) Confidence 0.81 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.26
However, regulation of the ERK phosphorylation in response to psychostimulants is not as robust in the VTA as in the NAcc.
Phosphorylation (phosphorylation) of ERK associated with nucleus accumbens and ventral tegmentum
5) Confidence 0.81 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.61
Phosphorylation of extracellular signal-regulated protein kinase (ERK) in the spinal dorsal horn was determined immunohistochemically.
Spec (determined) Phosphorylation (Phosphorylation) of ERK in spinal
6) Confidence 0.80 Published 2009 Journal Gut Section Body Doc Link 18852258 Disease Relevance 0.09 Pain Relevance 0
Phosphorylation of ERK in the spinal dorsal horn was detected following intracolonic NaHS or capsaicin.
Phosphorylation (Phosphorylation) of ERK in dorsal horn
7) Confidence 0.80 Published 2009 Journal Gut Section Body Doc Link 18852258 Disease Relevance 0.07 Pain Relevance 0
Phosphorylation of extracellular signal-regulated protein kinase (ERK) in the spinal dorsal horn was determined immunohistochemically.
Spec (determined) Phosphorylation (Phosphorylation) of extracellular signal-regulated protein kinase in spinal
8) Confidence 0.80 Published 2009 Journal Gut Section Body Doc Link 18852258 Disease Relevance 0.09 Pain Relevance 0
Extracellular signal-regulated kinase (ERK) 1/2 phosphorylation was increased by 5F203, and inhibition of ERK1/2 phosphorylation abolished the induction of NAG-1 protein expression and increased the stability of NAG-1 mRNA.
Phosphorylation (phosphorylation) of ERK
9) Confidence 0.80 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.77 Pain Relevance 0.22
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Phosphorylation (phosphorylation) of extracellular signal-regulated protein kinase in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
10) Confidence 0.79 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.38 Pain Relevance 1.65
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Phosphorylation (phosphorylation) of ERK in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
11) Confidence 0.79 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.39 Pain Relevance 1.65
Although basal phosphorylated ERK is minimal in mouse spinal cords without noxious stimuli, we investigated whether expression of the DN MEK transgene would alter basal ERK activation in the DN MEK mice.
Phosphorylation (phosphorylated) of ERK in spinal cords
12) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.65 Pain Relevance 0.51
Levels of phosphorylated ERK in the lumbar spinal cords of naïve mice were determined by immunoblotting using a phospho-ERK-selective primary antibody.
Phosphorylation (phosphorylated) of ERK in spinal cords
13) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.49 Pain Relevance 0.39
We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.
Phosphorylation (phosphorylation) of ERK in brain associated with morphine
14) Confidence 0.78 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18850497 Disease Relevance 0.07 Pain Relevance 0.31
We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.
Phosphorylation (phosphorylation) of extracellular signal-regulated kinase in brain associated with morphine
15) Confidence 0.78 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18850497 Disease Relevance 0.07 Pain Relevance 0.31
Furthermore, we analyzed ERK1/2 phosphorylation in these cortical regions by using mouse models of inflammation.
Spec (analyzed) Phosphorylation (phosphorylation) of ERK1/2 associated with inflammation
16) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.54 Pain Relevance 0.82
Here we report a rapid and sustained phosphorylation of ERK1/2 in neurons of the ACC induced by persistent activation of nociceptors following CFA injection.
Phosphorylation (phosphorylation) of ERK1/2 in nociceptors associated with nociceptor and anterior cingulate cortex
17) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.22 Pain Relevance 0.53
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
Phosphorylation (phosphorylation) of ERK associated with agonist
18) Confidence 0.77 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0.06 Pain Relevance 0.23
Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation.
Phosphorylation (phosphorylation) of ERK in astrocytes
19) Confidence 0.77 Published 2003 Journal Brain Res. Section Title Doc Link 12834899 Disease Relevance 0.09 Pain Relevance 0.23
When we examined the activation of extracellular signal-regulated protein kinase (ERK) in dorsal root ganglion (DRG) neurons upon i.pl. injection of BK, phosphorylated ERK was mainly observed in unmyelinated neurons in sham-operated mice, and in case of nerve-injured mice, ERK was mainly activated in myelinated neurons and satellite cells.
Phosphorylation (phosphorylated) of ERK in DRG associated with ganglion cysts, dorsal root ganglion, unmyelinated and bradykinin
20) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 0.96 Pain Relevance 1.16

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