INT92437

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 113
Total Number 114
Disease Relevance 32.19
Pain Relevance 40.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
Neuro-2a 10
astrocytes 10
spinal 6
medulla 6
T cells 6
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 223 100.00 Very High Very High Very High
withdrawal 148 100.00 Very High Very High Very High
nMDA receptor 104 100.00 Very High Very High Very High
Kinase C 406 99.96 Very High Very High Very High
qutenza 13 99.96 Very High Very High Very High
fluoxetine 24 99.92 Very High Very High Very High
Nucleus accumbens 21 99.84 Very High Very High Very High
antinociception 12 99.84 Very High Very High Very High
Inflammation 399 99.82 Very High Very High Very High
Morphine 111 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 125 99.98 Very High Very High Very High
Apoptosis 226 99.84 Very High Very High Very High
INFLAMMATION 434 99.82 Very High Very High Very High
Targeted Disruption 173 99.72 Very High Very High Very High
Injury 31 99.72 Very High Very High Very High
Neuropathic Pain 128 99.70 Very High Very High Very High
Cancer 446 99.64 Very High Very High Very High
Appetite Loss 46 99.64 Very High Very High Very High
Diabetes Mellitus 141 99.56 Very High Very High Very High
Urological Neuroanatomy 10 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All drugs of abuse increased ERK phosphorylation in nucleus accumbens, lateral bed nucleus of the stria terminalis, central amygdala and deep layers of prefrontal cortex, through a dopamine D1 receptor-dependent mechanism.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in prefrontal associated with nucleus accumbens, dopamine and amygdala
1) Confidence 0.70 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.70
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of extracellular signal-regulated protein kinase in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
2) Confidence 0.66 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.39 Pain Relevance 1.65
Consistently, ERK phosphorylation, enhanced in 4-week diabetic mice (P < 0.01), was significantly (P < 0.01) attenuated by AT1R blockade with telmisartan or valsartan to the level equivalent with that in nondiabetic mice (Fig. 1D and E).
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of ERK associated with diabetes mellitus
3) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.73 Pain Relevance 0
Out of several signaling molecules in the downstream of AT1R, the phosphorylation of ERK, but not Akt or STAT3, was required for synaptophysin degradation (Fig. 5), suggesting that the UPS-dependent synaptophysin degradation is mediated by ERK activation.
Positive_regulation (required) of Phosphorylation (phosphorylation) of ERK
4) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.11 Pain Relevance 0
Extracellular signal-regulated kinase (ERK) 1/2 phosphorylation was increased by 5F203, and inhibition of ERK1/2 phosphorylation abolished the induction of NAG-1 protein expression and increased the stability of NAG-1 mRNA.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK
5) Confidence 0.56 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.72 Pain Relevance 0.22
Distinct spinal neurotransmission is involved stimuli-induced spinal ERK phosphorylation in different fibers
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK in spinal
6) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2488330 Disease Relevance 0.48 Pain Relevance 0.39
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK associated with paracetamol
7) Confidence 0.52 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.35 Pain Relevance 1.04
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
8) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.26
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
9) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.25
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Positive_regulation (withdrawal-induced) of Phosphorylation (phosphorylation) of ERK in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
10) Confidence 0.48 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.39 Pain Relevance 1.66
Naloxone-precipitated withdrawal enhances ERK phosphorylation in prefrontal association cortex and accumbens nucleus of morphine-dependent mice.
Positive_regulation (enhances) of Phosphorylation (phosphorylation) of ERK in prefrontal associated with nucleus accumbens, narcan, withdrawal and morphine
11) Confidence 0.47 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 19922770 Disease Relevance 1.01 Pain Relevance 1.38
We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK in brain associated with morphine
12) Confidence 0.47 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18850497 Disease Relevance 0.07 Pain Relevance 0.31
We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of extracellular signal-regulated kinase in brain associated with morphine
13) Confidence 0.47 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18850497 Disease Relevance 0.07 Pain Relevance 0.31
Phenylephrine caused ERK phosphorylation only at a concentration high enough to exert non subtype-specific effects (10 microM), and this effect was counteracted by the alpha(2)-adrenergic antagonist atipamezole.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of ERK associated with antagonist
14) Confidence 0.47 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0.06 Pain Relevance 0.23
Co-administration of nociceptin (10 fmol/mouse) significantly attenuated memory impairment, while it did not attenuate the inhibition of training-dependent phosphorylation of ERK2 induced by U0126.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK2 associated with cognitive disorder and orphanin
15) Confidence 0.47 Published 2010 Journal Neurobiol Learn Mem Section Abstract Doc Link 20026233 Disease Relevance 0.70 Pain Relevance 0.71
However, this did not appear to influence nociceptive processing, since inflammation-induced ERK2 phosphorylation and pERK1/2 immunoreactivity in spinal cord were not elevated in ERK1 KO mice.
Neg (not) Positive_regulation (elevated) of Phosphorylation (phosphorylation) of ERK2 in spinal cord associated with nociception, inflammation and spinal cord
16) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739576 Disease Relevance 1.04 Pain Relevance 0.39
Interestingly, ERK1 deletion resulted in elevated basal ERK2 phosphorylation.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of ERK2
17) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739576 Disease Relevance 1.19 Pain Relevance 0.39
Interestingly, ERK1 deletion resulted in elevated basal ERK2 phosphorylation.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of ERK2
18) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739576 Disease Relevance 1.19 Pain Relevance 0.39
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.
Positive_regulation (causes) of Phosphorylation (phosphorylation) of ERK in astrocytes associated with fluoxetine
19) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Title Doc Link 18758753 Disease Relevance 0 Pain Relevance 0.29
Part of these receptors in brain are on astrocytes, where fluoxetine causes an increase in free cytosolic calcium concentration ([Ca(2+)](i)) and phosphorylation of extracellular regulated kinase 1 and 2 (ERK(1/2)).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of extracellular regulated kinase 1 and 2 in astrocytes associated with fluoxetine
20) Confidence 0.45 Published 2008 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 18758753 Disease Relevance 0 Pain Relevance 0.27

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