INT92447

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.81
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
leukocyte 2
neural 2
mononuclear phagocytes 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 168 100.00 Very High Very High Very High
substance P 108 100.00 Very High Very High Very High
calcitonin gene related peptide 32 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
antagonist 38 99.72 Very High Very High Very High
Inflammation 123 99.60 Very High Very High Very High
Neurotransmitter 36 99.36 Very High Very High Very High
Pain 16 97.72 Very High Very High Very High
Inflammatory mediators 29 95.20 Very High Very High Very High
tetrodotoxin 6 94.00 High High
Disease Link Frequency Relevance Heat
Endometriosis 224 100.00 Very High Very High Very High
INFLAMMATION 143 99.60 Very High Very High Very High
Pain 19 97.72 Very High Very High Very High
Gastroesophageal Reflux Disease 24 96.16 Very High Very High Very High
Esophageal Disease 44 94.48 High High
Genetic Predisposition To Disease 1 90.48 High High
Neurogenic Inflammation 6 89.76 High High
Ganglion Cysts 2 89.28 High High
Congenital Anomalies 8 87.36 High High
Stress 34 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The 5 subsets of SpA share many clinical, immunohistochemical, and genetic features, including the common presence of human leukocyte antigen-B27 and the absence of rheumatoid factor.
Negative_regulation (absence) of Gene_expression (presence) of SpA in leukocyte
1) Confidence 0.35 Published 2008 Journal Semin. Arthritis Rheum. Section Body Doc Link 18166219 Disease Relevance 0.09 Pain Relevance 0
However, as shown in Figure 5, higher MTs observed in our patients do not seem to be related to SP duration.
Negative_regulation (related) of Gene_expression (duration) of SP
2) Confidence 0.32 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.09 Pain Relevance 0.31
The specific morphine receptor antagonist (naltrexone) blocked morphine-induced SP expression in human mononuclear phagocytes, supporting the concept of authentic morphine receptor-mediated regulation.
Negative_regulation (blocked) of Gene_expression (expression) of SP in mononuclear phagocytes associated with antagonist, substance p and morphine
3) Confidence 0.22 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.09 Pain Relevance 1.37
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Negative_regulation (inhibition) of Gene_expression (migration) of SP associated with inflammation and substance p
4) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.65
Increased levels of neurotransmitters in both mucosa and supernatant imply de novo production of both CGRP and SP, requiring the presence of neural cell bodies in the sac.
Negative_regulation (imply) of Gene_expression (production) of SP in neural associated with calcitonin gene related peptide, neurotransmitter and substance p
5) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.51 Pain Relevance 0.76
Translation is halted by the presence of specific miRNAs which transiently inhibit SP production (26).
Negative_regulation (inhibit) of Gene_expression (production) of SP associated with substance p
6) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.08 Pain Relevance 0.82
To date, published evidence on the expression of SP in endometriosis is very limited; some authors report no changes of SP in endometriosis, which could be due to the difficulties in detecting SP because it is a rather small peptide of no more than 11 amino acids [170].
Negative_regulation (limited) of Gene_expression (expression) of SP associated with endometriosis and substance p
7) Confidence 0.01 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.36 Pain Relevance 1.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox