INT9246

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 113
Total Number 116
Disease Relevance 52.73
Pain Relevance 18.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 12
plasma 5
spinal cord 4
hippocampus 2
heart 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 16 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
Paracetamol 76 99.98 Very High Very High Very High
diclofenac 14 99.98 Very High Very High Very High
spinal inflammation 2 99.92 Very High Very High Very High
qutenza 12 99.84 Very High Very High Very High
Spinal cord 42 99.80 Very High Very High Very High
dexamethasone 20 99.72 Very High Very High Very High
Hippocampus 50 99.58 Very High Very High Very High
ischemia 144 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1247 100.00 Very High Very High Very High
Injury 489 100.00 Very High Very High Very High
Urological Neuroanatomy 136 100.00 Very High Very High Very High
Stress 657 99.98 Very High Very High Very High
Ulcers 157 99.96 Very High Very High Very High
Death 53 99.92 Very High Very High Very High
Reperfusion Injury 32 99.92 Very High Very High Very High
Low Back Pain 4 99.92 Very High Very High Very High
Cataract 120 99.86 Very High Very High Very High
Disorder Of Lipid Metabolism 234 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol also attenuated enhanced levels of malondialdehyde (MDA), peroxynitrite and produced increase in catalase levels in diabetic rats.
Positive_regulation (increase) of catalase associated with diabetes mellitus
1) Confidence 0.70 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289084 Disease Relevance 1.23 Pain Relevance 0.41
The PKA-specific inhibitor, Rp-cAMP, dampened isoproterenol-induced activation of CAT activity but did not alter ethanol's ability to increase CAT activity.
Positive_regulation (increase) of CAT
2) Confidence 0.67 Published 2000 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 10923996 Disease Relevance 0 Pain Relevance 0
The PKA-specific inhibitor, Rp-cAMP, dampened isoproterenol-induced activation of CAT activity but did not alter ethanol's ability to increase CAT activity.
Positive_regulation (activation) of CAT
3) Confidence 0.67 Published 2000 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 10923996 Disease Relevance 0 Pain Relevance 0
Forskolin (20 microM) stimulated CAT activity 4- to 9-fold with each construct.
Positive_regulation (stimulated) of CAT
4) Confidence 0.67 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7755638 Disease Relevance 0 Pain Relevance 0.16
CAT activity, however, in the hypothalamus was activated most on day 2.
Positive_regulation (activated) of CAT in hypothalamus
5) Confidence 0.67 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3773341 Disease Relevance 0.18 Pain Relevance 0.08
Taurine administration in ibuprofen-treated rats also showed a significant increase in the activities of the antioxidant enzymes namely total SOD, Mn-SOD, GPX, CAT, and the level of reduced GSH.
Positive_regulation (increase) of CAT
6) Confidence 0.67 Published 2004 Journal ScientificWorldJournal Section Abstract Doc Link 15632983 Disease Relevance 0.14 Pain Relevance 0.12
In dorsal spinal cord, there was a gradient in enzyme activity, increasing CAT activity being observed in more caudal segments.
Positive_regulation (increasing) of CAT in spinal cord associated with spinal cord
7) Confidence 0.67 Published 1986 Journal J. Neural Transm. Section Abstract Doc Link 3746289 Disease Relevance 0 Pain Relevance 0.41
Estrogen produced a dose-dependent increase in CAT activity in cotransfection assays with ERalpha expression vector and a 437PPE-CAT reporter construct containing 437 bp of the rat PPE gene promoter and the CAT reporter gene.
Positive_regulation (increase) of CAT
8) Confidence 0.67 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11457489 Disease Relevance 0.07 Pain Relevance 0
Investigated compounds also decreased levels of superoxide anions generation, increased catalase activity and level of reduced glutathione in liver.
Positive_regulation (increased) of catalase in liver
9) Confidence 0.64 Published 2000 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 10979583 Disease Relevance 0.17 Pain Relevance 0.15
Aminopyrine (300 mg/kg) increased the activities of catalase and FAOS.
Positive_regulation (increased) of catalase
10) Confidence 0.64 Published 1985 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3834060 Disease Relevance 0.14 Pain Relevance 0.25
Both doses of diclofenac increased catalase activity.
Positive_regulation (increased) of catalase associated with diclofenac
11) Confidence 0.63 Published 2006 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 17274466 Disease Relevance 0.49 Pain Relevance 0.45
Significantly enhanced catalase activity that was observed in all groups compared to the control indicates that the primary reactive oxygen species (ROS) metabolite is hydrogen peroxide, which decomposes very rapidly (very high catalase activity), thus hindering formation of OH radicals as the most toxic ROS.
Positive_regulation (enhanced) of catalase
12) Confidence 0.62 Published 2009 Journal Molecules Section Abstract Doc Link 19924083 Disease Relevance 0.75 Pain Relevance 0.14
Combined stress exhibited a prooxidative action (increased catalase activity, lowered content of reduced glutathione).
Positive_regulation (increased) of catalase associated with stress
13) Confidence 0.62 Published 2009 Journal Molecules Section Abstract Doc Link 19924083 Disease Relevance 0.75 Pain Relevance 0.15
Both paracetamol- and NO-paracetamol-treated groups showed increased activities of catalase and SOD compared with the vehicle group.
Positive_regulation (increased) of catalase associated with paracetamol
14) Confidence 0.62 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16172162 Disease Relevance 0.30 Pain Relevance 0.98
We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle.
Positive_regulation (increases) of catalase in skeletal muscle
15) Confidence 0.60 Published 1991 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 1936063 Disease Relevance 0.19 Pain Relevance 0.28
In the amygdala the lidocaine enhances the activities of catalase and GPX, but no SOD isoenzymes were modified.
Positive_regulation (enhances) of catalase in amygdala
16) Confidence 0.54 Published 2008 Journal Life Sci. Section Body Doc Link 18838081 Disease Relevance 0.05 Pain Relevance 0
In the hippocampus the catalase activity was enhanced, whereas the total SOD and Cu-Zn SOD activities were decreased.
Positive_regulation (enhanced) of catalase in hippocampus
17) Confidence 0.54 Published 2008 Journal Life Sci. Section Body Doc Link 18838081 Disease Relevance 0.06 Pain Relevance 0
Catalase level in granulation tissue was significantly increased in the case of alcoholic and aqueous extract 400?
Positive_regulation (increased) of Catalase in granulation
18) Confidence 0.54 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249741 Disease Relevance 0.11 Pain Relevance 0
In the present study, diabetic control rats showed significant increase in TBARS levels and decrease in SOD, catalase and glutathione levels in the rat liver homogenates compared to normal rats, indicating a dysfunction in antioxidant defensive system in diabetes mellitus.
Positive_regulation (increase) of catalase in liver associated with diabetes mellitus
19) Confidence 0.52 Published 2010 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2859276 Disease Relevance 1.16 Pain Relevance 0
Oral administration of l-NAME has been shown to increase catalase activity also in other situations (Mara et al 2007).
Positive_regulation (increase) of catalase
20) Confidence 0.51 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496980 Disease Relevance 0.16 Pain Relevance 0.08

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