INT92466

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
medulla 6
pons 2
Pomc (Mus musculus)
Crygs (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 28 99.24 Very High Very High Very High
opioid receptor 63 99.18 Very High Very High Very High
antagonist 35 98.72 Very High Very High Very High
Enkephalin 15 97.12 Very High Very High Very High
agonist 14 96.96 Very High Very High Very High
Opioid 2 95.80 Very High Very High Very High
Endogenous opioid 7 91.92 High High
Dynorphin 1 79.92 Quite High
Morphine 1 77.36 Quite High
mu opioid receptor 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta-endorphin (0.1 nM-10 microM) increased [35S]GTPgammaS binding in a concentration-dependent manner, and 10 microM beta-endorphin produced a maximal stimulation of approximately 260% over baseline.
Beta-endorphin Positive_regulation (increased) of GTPgammaS Binding (binding) of
1) Confidence 0.06 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.63
The present experiment was designed to determine which opioid receptors are involved in the stimulation of [35S]GTPgammaS binding induced by beta-endorphin in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of GTPgammaS Binding (binding) of in medulla associated with medulla and opioid receptor
2) Confidence 0.06 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.55
These results indicate that the stimulation of [35S]GTPgammaS binding induced by beta-endorphin is mediated by the stimulation of both mu- and putative epsilon-opioid receptors in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of GTPgammaS Binding (binding) of in medulla associated with medulla and opioid receptor
3) Confidence 0.06 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.74
Moreover, the residual stimulation of [35S]GTPgammaS binding induced by beta-endorphin in the presence of the three opioid receptor antagonists was significantly attenuated by 100 nM of the putative epsilon-opioid receptor partial agonist beta-endorphin (1-27).
beta-endorphin Positive_regulation (induced) of GTPgammaS Binding (binding) of associated with antagonist, agonist and opioid receptor
4) Confidence 0.06 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.89
Beta-endorphin stimulated [35S]GTPgammaS binding by about 80% in the presence of 10 microM beta-FNA, 30 nM NTI and 100 nM nor-BNI.
Beta-endorphin Positive_regulation (stimulated) of GTPgammaS Binding (binding) of
5) Confidence 0.05 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.92
This was most prominent with beta-endorphin, which stimulated [35S]GTPgammaS binding in the MOR-1E expressing cells to a greater degree than [D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAMGO; 130%) and was far less effective than DAMGO in MOR-1C cells (44%).
beta-endorphin Positive_regulation (stimulated) of GTPgammaS Binding (binding) of associated with enkephalin
6) Confidence 0.02 Published 2004 Journal Synapse Section Abstract Doc Link 14579421 Disease Relevance 0 Pain Relevance 0.54
The present experiment was designed to determine which opioid receptors are involved in the stimulation of [35S]GTPgammaS binding induced by beta-endorphin in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of GTPgammaS in pons Binding (binding) of in medulla associated with medulla and opioid receptor
7) Confidence 0.02 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.55
These results indicate that the stimulation of [35S]GTPgammaS binding induced by beta-endorphin is mediated by the stimulation of both mu- and putative epsilon-opioid receptors in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of GTPgammaS in pons Binding (binding) of in medulla associated with medulla and opioid receptor
8) Confidence 0.02 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.74

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