INT92476

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 7.78
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Gzmb) cytoplasm (Gzmb)
Anatomy Link Frequency
T cells 12
blood 1
NK cells 1
effector T cells 1
Gzmb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2 97.72 Very High Very High Very High
rheumatoid arthritis 272 96.56 Very High Very High Very High
Multiple sclerosis 158 93.96 High High
abdominal pain 2 92.64 High High
Inflammatory response 4 90.20 High High
headache 1 86.52 High High
anticonvulsant 1 85.76 High High
cytokine 140 81.20 Quite High
tolerance 21 78.80 Quite High
Paracetamol 1 77.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 27 99.76 Very High Very High Very High
Lymphatic System Cancer 12 99.76 Very High Very High Very High
Apoptosis 13 99.12 Very High Very High Very High
Rheumatoid Arthritis 272 96.56 Very High Very High Very High
Injury 6 94.92 High High
Demyelinating Disease 175 93.96 High High
Abdominal Pain 2 92.64 High High
Exanthema 8 92.20 High High
Congenital Anomalies 39 92.08 High High
Disease 123 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this scenario, fate decisions would be taken before the first cell division, and even though cells destined to become memory cells may transiently display traits associated with effector T cells (e.g., expression of granzyme B or IFN-?
Gene_expression (expression) of granzyme B in effector T cells
1) Confidence 0.58 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882844 Disease Relevance 0 Pain Relevance 0
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Gene_expression (Expression) of granzyme B in T cells
2) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Gene_expression (expression) of granzyme B in T cells
3) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
To characterize CD8+CD94+T cells, we examined the intracellular expression of granzyme B, perforin and Foxp3.
Spec (examined) Gene_expression (expression) of granzyme B in T cells
4) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3, the expression of intracellular granzyme B, perforin and Foxp3 in fresh CD8+CD94+T cells was minimal(~0.04%, ~0.01% and ~0.01%) in ACAID mice, immunized mice, PBS-AC-injected mice and naïve mice.
Gene_expression (expression) of granzyme B in T cells
5) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Flow cytometric analysis showed that very few CD8+CD94+T cells express granzyme B, perforin and Foxp3.
Gene_expression (express) of granzyme B in T cells
6) Confidence 0.21 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
Analysis of the expression of perforin and granzyme B, two important molecules for cytotoxicity, on CD8+CD94+T only revealed a moderate expression.
Gene_expression (expression) of granzyme B
7) Confidence 0.21 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.16 Pain Relevance 0.08
The very low production of granzyme B and perforin by CD8+CD94+T cells in each group in this study suggests that these two molecules are not involved in the development of ACAID.
Gene_expression (production) of granzyme B in T cells
8) Confidence 0.21 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.12 Pain Relevance 0.06
Very few CD8+CD94+T cells express granzyme B, perforin and Foxp3.
Gene_expression (express) of granzyme B in T cells
9) Confidence 0.21 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.09 Pain Relevance 0
+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.
Gene_expression (expression) of granzyme B in T cells
10) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.38 Pain Relevance 0.31
In our study both patient groups had granzyme B expression patterns indistinguishable from those seen in healthy controls, suggesting that the observed NK dysfunction is not likely to be related to abnormal granzyme B expression.
Gene_expression (expression) of granzyme B
11) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.28 Pain Relevance 0.04
In our study both patient groups had granzyme B expression patterns indistinguishable from those seen in healthy controls, suggesting that the observed NK dysfunction is not likely to be related to abnormal granzyme B expression.
Gene_expression (expression) of granzyme B
12) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.35 Pain Relevance 0.04
The unpaired t-test and Wilcoxon two-sample test were used to compare NK cytolytic activity and perforin/granzyme B expression between the patient and control groups.
Gene_expression (expression) of granzyme B
13) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.12 Pain Relevance 0.06
The main purpose of this cross-sectional study was to characterize numbers of circulating NK cells, their cytolytic activity, CD56bright : CD56dim subset ratio, and perforin/granzyme B expression in the major cytotoxic cell populations in patients with different clinical forms of JRA.


Gene_expression (expression) of granzyme B in NK cells associated with rheumatoid arthritis
14) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.37 Pain Relevance 0.27
Relative and absolute numbers of NK, CD8+, and NK T cells, as well as perforin and granzyme B expression in these cell populations, were determined as described previously [14,21].
Gene_expression (expression) of granzyme B in T cells
15) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.73 Pain Relevance 0.19
Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR alpha/beta and TCR gamma/delta.
Gene_expression (positive) of granzyme B associated with cancer
16) Confidence 0.09 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 11107059 Disease Relevance 0.69 Pain Relevance 0.08
A case of primary gastric T-cell lymphoma, which was positive for granzyme B, is reported.
Gene_expression (positive) of granzyme B in T-cell associated with lymphatic system cancer
17) Confidence 0.09 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 11107059 Disease Relevance 0.55 Pain Relevance 0.09
Besides injurious proinflammatory molecules, proapoptotic factors produced by T cells, including FasL, granzyme B, soluble TNF-related apoptosis-inducing ligand (TRAIL), glutamate, nitric oxide, and free radicals, are possible mediators of injury [208, 211–214].
Gene_expression (produced) of granzyme B in T cells associated with glutamate, injury and apoptosis
18) Confidence 0.05 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.12 Pain Relevance 0.38
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Gene_expression (expression) of granzyme B in blood
19) Confidence 0.03 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23
These neoplastic cells expressed CD30, CD43, granzyme B and T-cell intracellular antigen-1, but not ALK1, CD3, CD20, CD45, CD79a, cytokeratin, and EMA.
Neg (not) Gene_expression (expressed) of granzyme B in T-cell
20) Confidence 0.03 Published 2001 Journal Pathol. Res. Pract. Section Abstract Doc Link 11569930 Disease Relevance 0.40 Pain Relevance 0.09

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