INT92486

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.56
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX3) transport (P2RX3) Golgi apparatus (P2RX3)
Anatomy Link Frequency
neurons 4
embryonic kidney 2
P2RX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
interstitial cystitis 1 98.68 Very High Very High Very High
Lasting pain 1 98.60 Very High Very High Very High
Inflammation 2 98.22 Very High Very High Very High
medulla 1 92.52 High High
agonist 3 89.28 High High
Nerve growth factor 1 89.12 High High
Calcitonin gene-related peptide 1 87.20 High High
Neuropeptide 1 85.92 High High
Migraine 6 84.92 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 99.02 Very High Very High Very High
Interstitial Cystitis 1 98.68 Very High Very High Very High
Pain 17 98.60 Very High Very High Very High
INFLAMMATION 5 98.22 Very High Very High Very High
Hypersensitivity 1 97.16 Very High Very High Very High
Migraine Disorders 6 84.92 Quite High
Ganglion Cysts 3 76.20 Quite High
Renal Colic 2 65.04 Quite High
Pressure Volume 2 Under Development 1 61.32 Quite High
Diuresis 1 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane currents and changes in the intracellular Ca2+ concentration ([Ca2+]i) were measured in HEK293 cells transfected with the human P2X3 receptor (HEK293-hP2X3).
Positive_regulation (transfected) of Gene_expression (transfected) of P2X3
1) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.12
Recent studies indicate that acute, long-lasting sensitization of trigeminal nociceptive neurons occurs via distinct processes involving enhanced expression and function of adenosine triphosphate (ATP)-gated P2X3 receptors known to play a role in chronic pain.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X3 in neurons associated with nociception, adenocard and lasting pain
2) Confidence 0.49 Published 2008 Journal Mol. Neurobiol. Section Abstract Doc Link 18459072 Disease Relevance 0.83 Pain Relevance 0.99
There is evidence from the rat bladder that in certain pathological conditions, such as inflammation (interstitial cystitis), P2X3 receptors become sensitised and there is also a prominent increase in the number of P2X3 receptor-positive neurons in pelvic and lumbar splanchnic pathways, perhaps contributing to the hypersensitivity seen in pathophysiological conditions [22].
Positive_regulation (increase) of Gene_expression (neurons) of P2X3 receptor-positive in neurons associated with inflammation, hypersensitivity and interstitial cystitis
3) Confidence 0.41 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583211 Disease Relevance 0.73 Pain Relevance 0.44
Membrane currents in response to the application of alpha, beta-methylene ATP (alpha,beta-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells).
Positive_regulation (transfected) of Gene_expression (transfected) of P2X3 receptor in embryonic kidney
4) Confidence 0.37 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11108830 Disease Relevance 0 Pain Relevance 0.16
Membrane currents and changes in the intracellular Ca2+ concentration ([Ca2+]i) were measured in HEK293 cells transfected with the human P2X3 receptor (HEK293-hP2X3).
Positive_regulation (transfected) of Gene_expression (transfected) of P2X3 receptor
5) Confidence 0.21 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.12

General Comments

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