INT92493

Context Info Confidence 0.75 First Reported 2000 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 19 Total Number 30 Disease Relevance 11.28 Pain Relevance 10.08

mitochondrion (Fdps) nucleolus (Fdps) peroxisome (Fdps) nucleus (Fdps) cytoplasm (Fdps)

Anatomy Link Frequency midbrain 3 brain 2 brain stem 2 cortex 1 Fdps (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 96 99.16 midbrain 96 99.08 deep brain stimulation 15 98.84 Antinociceptive 24 98.60 Pain 194 98.28 pain suppression 6 98.24 antinociception 12 97.40 Lasting pain 10 95.76 cytokine 28 95.12 Thalamus 52 94.92

Disease Link Frequency Relevance Heat Cancer 74 98.96 Emergencies 36 98.84 Pain 224 98.28 Toxicity 1 97.76 Disease 216 96.64 Incontinence 24 96.48 Anxiety Disorder 4 95.96 Urological Neuroanatomy 108 94.92 Disseminated Intravascular Coagulation 38 94.60 Colon Cancer 12 92.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While FPs expressed a need for guidelines on cancer follow-up, several guidelines have been published.

Gene_expression (expressed) of FPs associated with cancer

1) Confidence 0.75 Published 2004 Journal BMC Fam Pract Section Body Doc Link PMC535864 Disease Relevance 0.42 Pain Relevance 0

Clinical practice guidelines (CPGs) can provide FPs with information and guidance on evidence-based best practices.

Gene_expression (provide) of FPs

2) Confidence 0.57 Published 2004 Journal BMC Fam Pract Section Body Doc Link PMC535864 Disease Relevance 0.34 Pain Relevance 0.06

OBJECTIVES: Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pretreatment were assessed.

Gene_expression (expression) of FPS

3) Confidence 0.53 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18324390 Disease Relevance 0.19 Pain Relevance 0

If FPs rely on the initiative of the DNs, unaware of the unsatisfactory grounds for relying on the DN, the home care patients will be left without proper support for their medical treatment.

Gene_expression (rely) of FPs

4) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0 Pain Relevance 0

One reason FPs did not know which of their patients had home care was that FPs and DNs worked in different organisations.

Gene_expression (worked) of FPs

5) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.10 Pain Relevance 0

Factors that influence FPs' experiences of satisfactory grounds for relying on the DNs

Gene_expression (experiences) of FPs

6) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.43 Pain Relevance 0

Factors that influence how much of the initiative the FPs retain

Gene_expression (retain) of FPs

7) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.42 Pain Relevance 0

All but three FPs worked in the same organisation as the DNs.

Gene_expression (worked) of FPs

8) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0 Pain Relevance 0

The FPs' working conditions

Gene_expression (The) of FPs

9) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.58 Pain Relevance 0.06

As the FPs were usually fully booked, it was difficult to manage emergency home visits.

Gene_expression (booked) of FPs associated with emergencies

10) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.10 Pain Relevance 0

The FPs expected the DNs to assess the need for and provide necessary home care, manage contacts and meet with family and neighbours, home help staff and hospitals to coordinate care and treatment.

Gene_expression (expected) of FPs

11) Confidence 0.31 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2984454 Disease Relevance 0.05 Pain Relevance 0

It may be possible to use the presence of these slow FPs and the effect of trial PVG DBS on both the clinical status and the FPs to predict the probable success of future pain control in individual patients.

Gene_expression (presence) of FPs associated with pain and deep brain stimulation

12) Confidence 0.25 Published 2003 Journal Pain Section Abstract Doc Link 12507704 Disease Relevance 0.88 Pain Relevance 1.05

Interestingly, we detected low frequency thalamic FPs at 0.2-0.4 Hz closely associated with the pain.

Gene_expression (detected) of FPs associated with pain

13) Confidence 0.25 Published 2003 Journal Pain Section Abstract Doc Link 12507704 Disease Relevance 1.09 Pain Relevance 1.39

Interestingly, we detected low frequency FPs at 0.2-0.4 Hz closely associated with the pain.

Gene_expression (detected) of FPs associated with pain

14) Confidence 0.25 Published 2002 Journal Pain Section Abstract Doc Link 12031778 Disease Relevance 0.92 Pain Relevance 1.19

However, the antinociceptive effect of Statins also appears to be tightly related to reducing the production of FPP in that exogenous malvonate, the precursor of FPP, reversed the antinociception by Statins in the same study.

Gene_expression (production) of FPP associated with antinociception and antinociceptive

15) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.48 Pain Relevance 0.42

For FPP extractions, tissue was homogenized on ice in an ethanol/butanol/70 mM (1:1.25:1.25. v/v/v) ammonium hydroxide solution using a polytron homogenizer.

Gene_expression (extractions) of FPP

16) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.55 Pain Relevance 0.91

FPP is synthesized from farnesol via two successive phosphorylation reactions mediated by farnesol kinase and farnesyl phosphate kinase, transitioning first through farnesyl monophosphate (FMP) then to FPP [20].

Gene_expression (synthesized) of FPP

17) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.66 Pain Relevance 0.47

In striatal slices, acute QA application dramatically inhibited corticostriatal field potentials (FPs), whose recovery was significantly higher in CNTF rats compared to controls (?

Gene_expression (recovery) of FPs

18) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.22

The highest production of FPP was measured in the brainstem (89.55E-12 ± 17.10E-12 moles/gram tissue), followed by the midbrain (56.95E-12 ± 19.89E-12) and thalamus (64.95E-12 ± 15.20E-12), moderate levels were measured in the hypothalamus (39.91E-12 ± 6.8E-12), cerebellum (33.62E-12 ± 8.94E-12), hippocampus (37.31E-12 ± 4.98E-12) and striatum (45.19E-12 ± 12.51E-12), and the lowest levels were measured in the pituitary (11.81E-12 ± 4.81E-12) and cortex (23.09E-12 ± 6.78E-12). 2.2.

Gene_expression (production) of FPP in midbrain associated with medulla, hippocampus, thalamus and midbrain

19) Confidence 0.19 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0 Pain Relevance 0.30

Here, we show that levels of FPP in rat cortex are ~7 ng/mg, so these levels are in an equivalent range.

Gene_expression (levels) of FPP in cortex

20) Confidence 0.19 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.65 Pain Relevance 0.58

General Comments

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