INT92507

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 9
Disease Relevance 5.46
Pain Relevance 0.46

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extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
plasma 14
platelets 4
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 9 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 9 99.54 Very High Very High Very High
Myocardial Infarction 72 99.36 Very High Very High Very High
Thrombosis 9 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the plasma of acute myocardial infarction patients contains factors that enhance shear-induced vWF binding and vWF-mediated platelet activation, which may contribute to thrombotic re-occlusions of the coronary arteries in patients who have received reperfusion treatments.
Positive_regulation (enhance) of vWF Binding (binding) of in plasma associated with myocardial infarction
1) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.57 Pain Relevance 0
The shear-induced increase in vWF binding to the platelet surface was enhanced in the presence of plasma from patients with acute myocardial infarction (acute myocardial infarction plasma).
Positive_regulation (increase) of vWF Binding (binding) of in plasma associated with myocardial infarction
2) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.75 Pain Relevance 0.07
The effects of plasma obtained from 15 patients with acute myocardial infarction and 10 patients with the chest pain syndrome as controls, on shear-induced vWF binding to platelets and subsequent platelet activation, as evidenced by microparticle release, were investigated by quantitative flow cytometry.
Spec (investigated) Positive_regulation (induced) of vWF Binding (binding) of in plasma associated with complex regional pain syndromes, angina and myocardial infarction
3) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.45 Pain Relevance 0.10
Acute myocardial infarction plasma also reduced the shear rate threshold required to induce measurable shear-induced vWF binding from 10800 s(-1) to 9000 s(-1).
Positive_regulation (induce) of vWF Binding (binding) of in plasma associated with myocardial infarction
4) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.65 Pain Relevance 0.05
We conclude that the plasma of acute myocardial infarction patients contains factors that enhance shear-induced vWF binding and vWF-mediated platelet activation, which may contribute to thrombotic re-occlusions of the coronary arteries in patients who have received reperfusion treatments.
Positive_regulation (induced) of vWF Binding (binding) of in plasma associated with myocardial infarction
5) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.57 Pain Relevance 0
Acute myocardial infarction plasma also reduced the shear rate threshold required to induce measurable shear-induced vWF binding from 10800 s(-1) to 9000 s(-1).
Positive_regulation (induced) of vWF Binding (binding) of in plasma associated with myocardial infarction
6) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.60 Pain Relevance 0
Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction.
Positive_regulation (induced) of von Willebrand factor Binding (binding) of in platelets associated with myocardial infarction
7) Confidence 0.66 Published 2000 Journal Thromb. Res. Section Title Doc Link 11113268 Disease Relevance 0.55 Pain Relevance 0.09
Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction.
Positive_regulation (Enhanced) of von Willebrand factor Binding (binding) of in platelets associated with myocardial infarction
8) Confidence 0.48 Published 2000 Journal Thromb. Res. Section Title Doc Link 11113268 Disease Relevance 0.55 Pain Relevance 0.09
The shear-induced increase in vWF binding to the platelet surface was enhanced in the presence of plasma from patients with acute myocardial infarction (acute myocardial infarction plasma).
Positive_regulation (enhanced) of vWF Binding (binding) of in plasma associated with myocardial infarction
9) Confidence 0.44 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.76 Pain Relevance 0.07

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