INT92509

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.41
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)
Anatomy Link Frequency
neurons 3
A7 neurons 1
Sh2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 265 100.00 Very High Very High Very High
tetrodotoxin 13 100.00 Very High Very High Very High
local anesthetic 6 100.00 Very High Very High Very High
lidocaine 3 100.00 Very High Very High Very High
dorsal root ganglion 68 99.56 Very High Very High Very High
Peripheral nervous system 30 96.48 Very High Very High Very High
imagery 9 94.64 High High
projection neuron 1 92.80 High High
Lasting pain 1 92.56 High High
Pain 17 91.44 High High
Disease Link Frequency Relevance Heat
Hypoxia 260 100.00 Very High Very High Very High
Ganglion Cysts 83 99.56 Very High Very High Very High
Pain 14 92.56 High High
Infection 95 90.84 High High
Increased Venous Pressure Under Development 1 76.48 Quite High
Disease 5 75.32 Quite High
Dyskinesias 1 74.24 Quite High
Nervous System Injury 2 67.52 Quite High
Pseudorabies 5 50.00 Quite Low
Non-diabetic Peripheral Neuropathy 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of the I(A) by 4-AP, a broad spectrum I(A) blocker, or by Hptx-2 increased the half-width and spontaneous firing of APs and reduced the amount of synaptic drive needed to elicit APs in CCM, showing that the I(A) play important roles in regulating the shape and firing frequency of APs and in synaptic integration in NAergic A7 neurons.
Regulation (regulating) of APs in A7 neurons associated with action potential
1) Confidence 0.35 Published 2010 Journal Neuroscience Section Abstract Doc Link 20381592 Disease Relevance 0 Pain Relevance 0.39
At the end of each experiment we measured the response to 1200 APs at 10 Hz in bafilomycin at 2?
Regulation (response) of APs
2) Confidence 0.23 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.08 Pain Relevance 0.40
Overall, we investigated in 137 cells the effects of moderate hypoxia on currents and actions potentials (APs) of small DRG neurones.
Spec (investigated) Regulation (effects) of APs associated with dorsal root ganglion, action potential and hypoxia
3) Confidence 0.18 Published 2006 Journal Mol Pain Section Body Doc Link PMC1484470 Disease Relevance 1.10 Pain Relevance 0.40
To investigate the oxygen sensitivity of small DRG-neurones in more detail we replaced the carbogen-bubbled solution by a control bubbled with 21% O2 (5% CO2, 74% N2) and tested the effects of moderate hypoxia on action potentials (APs) and currents of DRG neurones.
Regulation (effects) of APs associated with action potential, dorsal root ganglion and hypoxia
4) Confidence 0.18 Published 2006 Journal Mol Pain Section Body Doc Link PMC1484470 Disease Relevance 1.11 Pain Relevance 0.43
In an opposite fashion, the result of GBP application to injured neurons was a decreased number of APs during depolarization and no change in RI.
Neg (no) Regulation (change) of APs in neurons
5) Confidence 0.16 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15025616 Disease Relevance 0.13 Pain Relevance 0
Interestingly, IPSPs modified action potentials (APs) in a manner that suggested IPSPs enhanced postsynaptic Nav channel availability.
Regulation (modified) of APs associated with action potential
6) Confidence 0.12 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16162932 Disease Relevance 0.22 Pain Relevance 0.25
To test the effects of the clinically used local anesthetics lidocaine and bupivacaine on TTX-resistant action potentials (APs) in sensory neurons, we performed electrophysiological experiments on small dorsal root ganglion (DRG) neurons from young rats.
Regulation (effects) of APs in neurons associated with ganglion cysts, dorsal root ganglion, action potential, tetrodotoxin, lidocaine and local anesthetic
7) Confidence 0.11 Published 2000 Journal Pain Section Abstract Doc Link 11113292 Disease Relevance 0.36 Pain Relevance 1.75
However, by 8 hpi PRV 151 infected neurons began to fire APs at a mean elevated rate of 4.0±1.4 Hz (Figure 2A).
Regulation (fire) of APs in neurons
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox