INT92513

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 26
Total Number 31
Disease Relevance 9.12
Pain Relevance 13.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
spinal 2
CeA 2
neuronal 1
PNs 1
spinal cord 1
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 136 100.00 Very High Very High Very High
nMDA receptor 107 100.00 Very High Very High Very High
Kinase C 41 100.00 Very High Very High Very High
amygdala 33 100.00 Very High Very High Very High
Opioid 29 99.98 Very High Very High Very High
Stimulus evoked pain 1 99.80 Very High Very High Very High
opioid receptor 85 99.40 Very High Very High Very High
analgesia 6 99.28 Very High Very High Very High
narcan 6 99.28 Very High Very High Very High
Hippocampus 175 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 145 99.96 Very High Very High Very High
Pain 57 99.80 Very High Very High Very High
Hypersensitivity 10 99.60 Very High Very High Very High
Nociception 26 99.48 Very High Very High Very High
Injury 24 98.68 Very High Very High Very High
Opiate Addiction 11 98.28 Very High Very High Very High
Nervous System Injury 13 96.60 Very High Very High Very High
Neuropathic Pain 19 95.76 Very High Very High Very High
Death 54 94.68 High High
Urological Neuroanatomy 98 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to clarify the role of the NR1, NR2A and NR2B subunits of N-methyl-D-aspartate receptors in the development of morphine-induced place preference using specific antibodies to N-methyl-D-aspartate receptor subunits in the mouse.
Regulation (role) of NR1 associated with nmda receptor and morphine
1) Confidence 0.59 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.13 Pain Relevance 0.39
Thus, our results show that there is an age-dependent regulation of NMDAR subunits NR1 and NR2A, but not NR2B, in NT-3 +/- mice.
Regulation (regulation) of NR1
2) Confidence 0.59 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.08 Pain Relevance 0.24
However, irrespective of the molecular mechanisms underlying the observed effects, our data support a major role of PrPC in regulating NMDAR function.
Regulation (regulating) of NMDAR
3) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.24 Pain Relevance 0.08
After careful selection of proper experimental conditions and drug doses, we systematically characterized the effects of systemic ketamine on acute somatic nociception in mice and examined the role of the NMDA receptor epsilon1 subunit in mediating its analgesia.
Spec (examined) Regulation (role) of NMDA receptor epsilon1 subunit associated with nociception, ketamine, nmda receptor and analgesia
4) Confidence 0.48 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16427663 Disease Relevance 0.62 Pain Relevance 0.94
The purpose of the present study was to determine whether the NMDAR NR-1, a key subunit in regulation of NMDAR channel complex is directly contributing to the onset and propagation of peripheral nerve injury-induced allodynia and whether N-methyl-d-aspartate (NMDA) signaling interacts with spinal chemokine (chemotactic cytokines) expression and glial activation.
Spec (whether) Regulation (regulation) of NMDAR in spinal associated with chemokine, nervous system injury, allodynia, glial activation, cytokine and peripheral nerve injury
5) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.62 Pain Relevance 0.69
The purpose of the present study was to determine whether the NMDAR NR-1, a key subunit in regulation of NMDAR channel complex is directly contributing to the onset and propagation of peripheral nerve injury-induced allodynia and whether N-methyl-d-aspartate (NMDA) signaling interacts with spinal chemokine (chemotactic cytokines) expression and glial activation.
Spec (whether) Regulation (regulation) of NMDAR NR-1 in spinal associated with chemokine, nervous system injury, allodynia, glial activation, cytokine and peripheral nerve injury
6) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.62 Pain Relevance 0.69
The effects of intrathecal NMDA, AMPA, MK-801, NBQX, or NMDAR1 AS ODN on the antinociception of propofol were observed.
Regulation (effects) of NMDAR1 AS
7) Confidence 0.45 Published 2004 Journal Acta Pharmacol. Sin. Section Body Doc Link 14704116 Disease Relevance 0 Pain Relevance 0
To determine the importance of the NMDA receptor (NMDAR) in pain hypersensitivity after injury, the NMDAR1 (NR1) subunit was selectively deleted in the lumbar spinal cord of adult mice by the localized injection of an adenoassociated virus expressing Cre recombinase into floxed NR1 mice.
Spec (determine) Regulation (importance) of NMDAR in spinal cord associated with nmda receptor, injury, hypersensitivity, stimulus evoked pain and spinal cord
8) Confidence 0.45 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12832526 Disease Relevance 0.63 Pain Relevance 0.47
However, opioid-dependent CeA NR1 knockout mice failed to exhibit a conditioned place aversion induced by naloxone-precipitated withdrawal.
Regulation (dependent) of NR1 in CeA associated with targeted disruption, narcan, withdrawal, amygdala and opioid
9) Confidence 0.42 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.58 Pain Relevance 1.46
Reports in the literature indicate NMDAR function is modulated by mAChRs (Aramakis et al., 1999; Harvey et al., 1993; Marino et al., 1998; Markram and Segal, 1990, 1992).
Regulation (modulated) of NMDAR
10) Confidence 0.40 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.28
But until now, most of the evidence demonstrating the role of retinoids in regulating glutamate NMDA receptors (NR1, NR2) has come from in vitro studies [13].
Regulation (regulating) of NR1 associated with glutamate and nmda receptor
11) Confidence 0.40 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2832782 Disease Relevance 0.34 Pain Relevance 0.59
Amygdala NR1 gene deletion also did not affect locomotor, somatosensory, or sensory-motor behaviors.
Neg (not) Regulation (affect) of NR1 gene in Amygdala associated with amygdala
12) Confidence 0.36 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18614169 Disease Relevance 0.45 Pain Relevance 1.36
We showed that CX546 prolongs AMPAR-mediated EPSCs and that the prolongation is the same in wild-type and Neto1-null mice, but that it does not affect NMDAR-mediated EPSCs or paired pulse facilitation.
Neg (not) Regulation (affect) of NMDAR-mediated
13) Confidence 0.34 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.16
RT-PCR analysis of NMDAR subunit and PrP expression
Regulation (analysis) of NMDAR
14) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
These data indicate that membrane depolarization and increased input resistance seen in the presence of XE-991 are not sufficient to occlude the effects of M1 receptor activation on NMDAR function.
Regulation (effects) of NMDAR
15) Confidence 0.29 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.06
We used genetically engineered male mice that had their normal NR1 gene knocked out and expressed a modified NR1 gene at either normal level (NR1 +/+, wild type) or at a low level (NR1+/-, knock down).
Regulation (modified) of NR1 associated with targeted disruption
16) Confidence 0.27 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.73 Pain Relevance 0.81
Here, we employed whole-cell patch-clamp techniques in acute brain slices, and electrical afferent and infrared-guided laser stimulation to examine how N(2)O (65%) can affect NMDA receptor (NMDAR)-mediated synaptic transmission to principal neurons (PNs) of the adult murine basolateral amygdala (BLA).
Regulation (affect) of NMDAR in PNs associated with nmda receptor and amygdala
17) Confidence 0.23 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17123554 Disease Relevance 0.26 Pain Relevance 0.45
Antinociceptive effects after intrathecal administration of phosphodiester-, 2'-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse.
Regulation (targeting) of NMDAR1 subunit associated with antinociceptive and intrathecal
18) Confidence 0.23 Published 2001 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11165368 Disease Relevance 0.18 Pain Relevance 0.56
In summary, our results identify PrPC as a regulator of NMDAR function and demonstrate that PrPC exerts a neuroprotective role by inhibiting aspects of NMDAR activity linked to excitotoxic cell death.
Regulation (regulator) of NMDAR associated with death
19) Confidence 0.23 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.71 Pain Relevance 0.11
Spatial learning in the Morris watermaze is dependent on NMDAR activation in the hippocampus [2], [4].
Regulation (dependent) of NMDAR in hippocampus associated with hippocampus
20) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.79 Pain Relevance 0.31

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