INT92514

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 11.07
Pain Relevance 16.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
lateral 1
neuron 1
brain 1
ACC neurons 1
PAG 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 346 100.00 Very High Very High Very High
Glutamate 193 100.00 Very High Very High Very High
depression 26 99.96 Very High Very High Very High
Central grey 616 99.76 Very High Very High Very High
nMDA receptor 400 99.52 Very High Very High Very High
Morphine 366 99.52 Very High Very High Very High
long-term potentiation 228 99.46 Very High Very High Very High
Analgesic 181 98.92 Very High Very High Very High
tolerance 156 98.68 Very High Very High Very High
antagonist 164 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 26 99.96 Very High Very High Very High
Urological Neuroanatomy 616 99.76 Very High Very High Very High
Injury 161 99.20 Very High Very High Very High
Hyperalgesia 78 97.44 Very High Very High Very High
Anxiety Disorder 33 97.32 Very High Very High Very High
Pain 251 96.80 Very High Very High Very High
INFLAMMATION 202 96.32 Very High Very High Very High
Targeted Disruption 115 91.80 High High
Nociception 83 91.08 High High
Inflammatory Pain 104 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our results show that there is an age-dependent regulation of NMDAR subunits NR1 and NR2A, but not NR2B, in NT-3 +/- mice.
Regulation (regulation) of NR2B
1) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.08 Pain Relevance 0.24
In the ACC, NMDA receptor-dependent plasticity including LTP and long-term depression, depend on both NR2B and NR2A subunit-containing NMDA receptors [13,14].
Regulation (depend) of NR2B associated with depression, nmda receptor, long-term potentiation and anterior cingulate cortex
2) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.51 Pain Relevance 0.96
The present study was designed to clarify the role of the NR1, NR2A and NR2B subunits of N-methyl-D-aspartate receptors in the development of morphine-induced place preference using specific antibodies to N-methyl-D-aspartate receptor subunits in the mouse.
Regulation (role) of NR2B associated with nmda receptor and morphine
3) Confidence 0.43 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.13 Pain Relevance 0.39
To test whether up-regulation of NR2B receptor leads to changes in NMDAR-mediated synaptic transmission, we measured NMDAR-mediated miniature excitatory postsynaptic currents (mEPSCs) in the presence of CNQX (an AMPA receptor antagonist) in the lateral periaqueductal gray (LPAG).
Regulation (regulation) of NR2B in lateral associated with antagonist and central grey
4) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.89 Pain Relevance 0.58
Administration of Hyp (100 mg/kg, i.g. twice daily for 3 days) reversed up-regulation of NR2B subunit in the LPAG of CFA-injected mice.


Regulation (regulation) of NR2B
5) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.93 Pain Relevance 0.58
It is reasonable to conclude that the enhancement in NMDARs is due to the up-regulation of NR2B-containing NMDARs in the PAG.
Regulation (regulation) of NR2B associated with central grey
6) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.15 Pain Relevance 1.25
It suggests a possible mechanism for an enhancement in NMDAR function is an up-regulation of NR2B-containing NMDARs in the PAG.


Regulation (regulation) of NR2B associated with central grey
7) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.71 Pain Relevance 0.37
Taken together, these results suggest that NVP does not significantly affect NR2B component and could be used as a selective antagonist for NR2A-containing NMDARs in the ACC.
Neg (not) Regulation (affect) of NR2B associated with antagonist and anterior cingulate cortex
8) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.10
Interestingly, NR2B over-expressing animals are not more susceptible to plasticity (Philpot et al. 2001), possibly because modulating NR2B transcript did not affect the NR2A/2B ratio in this study.
Spec (possibly) Regulation (modulating) of NR2B
9) Confidence 0.35 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.07 Pain Relevance 0.23
Up-regulation of NR2B is verified by the recordings of NMDAR-mediated mEPSCs.
Regulation (regulation) of NR2B
10) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.10 Pain Relevance 1.30
The down-regulated NR2B receptor is quite correlated with its analgesic effects on the thermal hyperalgesia induced by chronic inflammation.
Regulation (regulated) of NR2B associated with inflammation, thermal hyperalgesia and analgesic
11) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.20 Pain Relevance 0.99
The loss of synaptic NR2A-containing receptors in the Neto1-null mice implies that the molecular events regulating the delivery or stability of NR2A-NMDARs at the synapse differ from those regulating NR2B-NMDARs.
Regulation (regulating) of NR2B in synapse
12) Confidence 0.31 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Our electrophysiological data indicate that alterations in NR2B receptor function may not only occur at synaptic sites, but also at extrasynaptic areas.
Regulation (alterations) of NR2B
13) Confidence 0.26 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.15 Pain Relevance 1.38
To determine if NR2B receptors in the ACC were affected by chronic morphine treatment, ACC neurons were held at a potential of -20 mV to relieve the Mg2+ blockade and NMDA EPSCs were isolated in the presence of CNQX (50 ?
Regulation (affected) of NR2B in ACC neurons associated with anterior cingulate cortex and morphine
14) Confidence 0.26 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 0.89
Interestingly, NR2B over-expressing animals are not more susceptible to plasticity (Philpot et al. 2001), possibly because modulating NR2B transcript did not affect the NR2A/2B ratio in this study.
Spec (possibly) Regulation (modulating) of NR2B
15) Confidence 0.26 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.07 Pain Relevance 0.23
Synaptic neurotransmission, one of the significantly altered GO biological processes in Glud1 mice (Table 1), contained two of the most up-regulated genes in Glud1 mice, those for the two Glu-activated synaptic receptors, the N-methyl-d-aspartate (NMDA) Receptor Subunits 2A and 2B (Grin2A and Grin2B).
Regulation (regulated) of Grin2B associated with glutamate
16) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.42 Pain Relevance 0.29
Together with the present findings, we argue that NMDA NR2B subunit is highly sensitive to an enriched environment and peripheral injury.
Regulation (sensitive) of NMDA NR2B subunit associated with injury
17) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.68 Pain Relevance 0.40
Here we present evidence for a role of the NR2B subunit in development of analgesic tolerance.
Regulation (role) of NR2B associated with analgesic and tolerance
18) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 2.18
Our results suggest that drugs targeting the NR2B subunit may prove useful in attenuating analgesic tolerance to morphine that occurs clinically.


Regulation (targeting) of NR2B associated with analgesic, tolerance and morphine
19) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.17 Pain Relevance 1.49
Since NMDA receptors play an important role in activity-dependent plasticity in the ACC, we suggest that NMDA NR2B subunit may be regulated through NMDA-calcium-CaM-dependent signaling pathways.
Spec (may) Regulation (regulated) of NMDA NR2B subunit associated with nmda receptor and anterior cingulate cortex
20) Confidence 0.22 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.81 Pain Relevance 0.76

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