INT92515

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 84
Total Number 96
Disease Relevance 26.68
Pain Relevance 38.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
hippocampus 12
neurons 9
synapses 8
forebrain 5
dorsal horn 4
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 4032 100.00 Very High Very High Very High
Hippocampus 1465 100.00 Very High Very High Very High
Dorsal horn 376 99.84 Very High Very High Very High
Rostral ventromedial medulla 31 99.72 Very High Very High Very High
tolerance 445 99.70 Very High Very High Very High
Anterior cingulate cortex 219 99.68 Very High Very High Very High
cerebral cortex 216 99.68 Very High Very High Very High
Central grey 157 99.68 Very High Very High Very High
amygdala 37 99.68 Very High Very High Very High
Pain 266 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 1938 100.00 Very High Very High Very High
Targeted Disruption 1229 99.78 Very High Very High Very High
Urological Neuroanatomy 407 99.68 Very High Very High Very High
Pain 601 99.44 Very High Very High Very High
Disease 183 99.38 Very High Very High Very High
Sprains And Strains 137 99.28 Very High Very High Very High
Injury 107 99.28 Very High Very High Very High
Anxiety Disorder 139 99.12 Very High Very High Very High
Depression 393 99.02 Very High Very High Very High
Disseminated Intravascular Coagulation 85 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GluRepsilon1-/- mice showed marked loss of typical withdrawal abstinence behaviors, and significant enhancement of GluRepsilon1 protein expression was only observed in NAc by chronic morphine treatments after dependence paradigm.
Gene_expression (expression) of GluRepsilon1 protein in NAc associated with addiction, nucleus accumbens, withdrawal and morphine
1) Confidence 0.76 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12878694 Disease Relevance 0.41 Pain Relevance 2.07
In C57BL/6J mice treated with chronic morphine after tolerance paradigm, the GluRepsilon1 protein expression significantly increased in periaqueductal gray matter (PAG), ventral tegmental area (VTA) and nucleus accumbens (NAc), but not amygdala or hippocampus.
Gene_expression (expression) of GluRepsilon1 protein in PAG associated with ventral tegmentum, central grey, morphine, nucleus accumbens, tolerance, hippocampus, urological neuroanatomy and amygdala
2) Confidence 0.76 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12878694 Disease Relevance 0.51 Pain Relevance 1.95
In the present study we used RT-PCR methods on single cells and tissue to compare the expression of NMDAR subunits, NR1, NR2A and NR2B, in the striatum of R6/2 transgenic mice with their wild-type (WT) littermates at three different age groups corresponding to different symptomatic milestones (19-25 days showing no overt evidence of abnormal behavior, 38-45 days at the onset of the overt phenotype and 78-90 days displaying the full behavioral phenotype).
Gene_expression (expression) of NR2A in striatum associated with targeted disruption
3) Confidence 0.76 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.44 Pain Relevance 0.26
Cells that did not express NR2A contained both enkephalin and substance P, but proportionately more cells containing enkephalin displayed decreases in NR2A.
Neg (not) Gene_expression (express) of NR2A associated with enkephalin and substance p
4) Confidence 0.76 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.32 Pain Relevance 0.52
NR2A and NR2B are highly expressed in the ACC, a forebrain area involved in emotion, memory and pain [21,22].
Gene_expression (expressed) of NR2A in forebrain associated with pain and anterior cingulate cortex
5) Confidence 0.73 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.27 Pain Relevance 0.54
Using western blotting, NR1, NR2A and NR2B subunits were found to be highly expressed in the cerebral cortex and hippocampus of the mouse brain, which are key areas in producing seizures regulated by N-methyl-D-aspartate receptors.
Gene_expression (expressed) of NR2A in brain associated with convulsion, nmda receptor, hippocampus and cerebral cortex
6) Confidence 0.67 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.27 Pain Relevance 0.50
Targeted disruption of the PSD-93 gene reduces not only surface NR2A and NR2B expression but also NMDAR-mediated excitatory postsynaptic currents and potentials, without affecting surface AMPA receptor expression or its synaptic function, in the regions mentioned above.
Gene_expression (expression) of NR2A associated with targeted disruption
7) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.48 Pain Relevance 0.56
Blunted NMDAR-dependent neuronal plasticity following repeated morphine injection in PSD-93 KO mice is attributed to PSD-93 deletion-induced alterations of NR2A and NR2B postsynaptic expression in dorsal horn and forebrain cortex neurons, but not in cerebellar neurons.
Gene_expression (expression) of NR2A in neurons associated with targeted disruption, dorsal horn and morphine
8) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.74 Pain Relevance 1.22
The results showed a significant decrease in the percentage of cells expressing NR2A at all ages examined.
Gene_expression (expressing) of NR2A
9) Confidence 0.66 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.35 Pain Relevance 0.50
The expression of NR1 and all subunits of NR2 family (NR2A, NR2B, NR2C, NR2D) of NMDA receptor complex was examined using immunoblotting method.
Spec (examined) Gene_expression (expression) of NR2A associated with nmda receptor
10) Confidence 0.65 Published 2007 Journal Drug Alcohol Depend Section Abstract Doc Link 16930867 Disease Relevance 0.36 Pain Relevance 1.40
By alternating sequence of drug applications, we found that the presence of NVP did not significantly affect the effect of ifenprodil on NMDA EPSCs, suggesting that NVP is relatively selective for NR2A-containing NMDARs.
Gene_expression (selective) of NR2A
11) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.08 Pain Relevance 0.32
For instance, triheteromeric NMDA receptor, NR1/NR2A/NR2B, has been found in native tissues, particularly in the cortex [5,25].
Gene_expression (/) of NR2A in cortex associated with nmda receptor
12) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.07 Pain Relevance 0.22
Single-cell RT-PCR analysis performed on superficial dorsal horn neurons showed that the incidence of NR2A mRNA-expressing neurons was reduced in nerve-ligated neuropathic mice.
Gene_expression (expressing) of NR2A in nerve associated with neuropathic pain and dorsal horn neuron
13) Confidence 0.62 Published 2007 Journal Brain Res. Section Abstract Doc Link 17198690 Disease Relevance 0.75 Pain Relevance 0.87
We hypothesized that animals deficient in GluRepsilon1, an abundant and ubiquitously postnatally expressed NMDAR subunit, might be resistant to the effects of ketamine.
Gene_expression (expressed) of GluRepsilon1 associated with ketamine
14) Confidence 0.58 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385364 Disease Relevance 0.08 Pain Relevance 0.36
To determine whether there was an overall decrease in cell surface expression of NR2A-containing NMDARs in Neto1-null mice, we quantified the abundance of biotinylated cell surface proteins in wild-type and Neto1-null hippocampal slices.
Gene_expression (expression) of NR2A-containing
15) Confidence 0.57 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.06
Furthermore, several lines of evidence suggest that the enhanced NMDA currents in cultured neurons are not caused by an enhanced expression of NR2A and/or NR2B subunits.
Gene_expression (expression) of NR2A in neurons
16) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.07
These effects indicate that both NR2A and NR2B are expressed at these synaptic sites in lamina II.
Gene_expression (expressed) of NR2A in lamina
17) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.42
Furthermore, we found evidence that only NR2A and NR2B subunits are expressed as synaptic NMDA receptors in nearly identical proportions on both inhibitory and excitatory interneurons.
Gene_expression (expressed) of NR2A in interneurons associated with nmda receptor
18) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.14 Pain Relevance 0.37
Effect of PSD-93 deletion on the expression of NR2A and NR2B in total soluble and synaptosomal membrane fractions
Gene_expression (expression) of NR2A
19) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.06 Pain Relevance 0.10
Immunoblot analysis showed that PSD-93 deletion did not alter expression of NR2A and NR2B in total soluble fractions from dorsal horn, forebrain cortex, or cerebellum of mice (Fig. 1A), a finding consistent with those in previous studies [16,21,30].
Gene_expression (expression) of NR2A in cerebellum associated with dorsal horn
20) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.13 Pain Relevance 0.12

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