INT92516

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.53
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
brain 2
hippocampus 2
neural 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 119 100.00 Very High Very High Very High
Morphine 83 100.00 Very High Very High Very High
Hippocampus 51 100.00 Very High Very High Very High
Central grey 77 99.68 Very High Very High Very High
cerebral cortex 1 99.68 Very High Very High Very High
Kinase C 40 99.40 Very High Very High Very High
opioid receptor 84 95.68 Very High Very High Very High
nMDA receptor 53 95.40 Very High Very High Very High
depression 136 94.16 High High
Dorsal horn 3 93.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 95 99.68 Very High Very High Very High
Convulsion 10 96.48 Very High Very High Very High
Depression 136 94.16 High High
Nociception 16 89.52 High High
Repression 67 87.84 High High
Injury 18 84.88 Quite High
Neuralgia 1 83.08 Quite High
Herpes Simplex Virus Infection 1 82.68 Quite High
Pain 27 82.08 Quite High
Intractable Pain 2 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using western blotting, NR1, NR2A and NR2B subunits were found to be highly expressed in the cerebral cortex and hippocampus of the mouse brain, which are key areas in producing seizures regulated by N-methyl-D-aspartate receptors.
Positive_regulation (highly) of Gene_expression (expressed) of NR1 in brain associated with convulsion, nmda receptor, hippocampus and cerebral cortex
1) Confidence 0.45 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.27 Pain Relevance 0.50
The latter study supports the notion that neural activity is a regulating factor for NR1 expression.
Positive_regulation (factor) of Gene_expression (expression) of NR1 in neural
2) Confidence 0.43 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.19
As we predicted, Hyp reversed the enhanced NMDAR-mediated transmission in the PAG of CFA-injected mice (Frequency: 0.42 ± 0.05 Hz, n = 6; amplitude: 11.3 ± 1.1 pA, n = 8, p < 0.05 vs CFA-injected alone; Fig. 3).
Positive_regulation (enhanced) of Gene_expression (transmission) of NMDAR-mediated associated with central grey
3) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.81 Pain Relevance 0.43
In response to morphine, NMDAR-nNOS generated zinc recruits PKC?
Positive_regulation (response) of Gene_expression (generated) of NMDAR associated with kinase c and morphine
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.86 Pain Relevance 1.60
Additionally, in rats, NMDAR-dependent LTP can be induced in layers 4 and 3 in vivo following tetanic stimulation of LGN, and this LTP is sufficient to increase the magnitude of visually evoked responses (Heynen & Bear 2001).
Positive_regulation (increase) of Gene_expression (sufficient) of NMDAR associated with long-term potentiation
5) Confidence 0.27 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.17 Pain Relevance 0.40
The discovery of SRP demonstrates that physiologically relevant potentiation of visual responses can occur in vivo, and shares a requirement for NMDAR activation with LTP.
Positive_regulation (requirement) of Gene_expression (activation) of NMDAR associated with long-term potentiation
6) Confidence 0.27 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.16 Pain Relevance 0.27
Consequently, a potential mechanism for NMDAR-independent learning and plasticity in the hippocampus is the expression and activation of GluR2-lacking (Ca2+-permeable) AMPARs.
Positive_regulation (activation) of Gene_expression (expression) of NMDAR in hippocampus associated with hippocampus
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.35
Moreover, the NR1 E21 3?
Positive_regulation (Moreover) of Gene_expression (Moreover) of NR1
8) Confidence 0.24 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.21 Pain Relevance 0.04

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