INT92517

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 2
Speculated 4
Reported most in Abstract
Documents 105
Total Number 111
Disease Relevance 29.53
Pain Relevance 39.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
neurons 7
hippocampus 6
synapses 6
brain 5
CeA 4
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1024 100.00 Very High Very High Very High
long-term potentiation 892 100.00 Very High Very High Very High
Hippocampus 633 100.00 Very High Very High Very High
Glutamate 380 100.00 Very High Very High Very High
antagonist 217 100.00 Very High Very High Very High
Neurotransmitter 98 100.00 Very High Very High Very High
amygdala 88 100.00 Very High Very High Very High
allodynia 47 100.00 Very High Very High Very High
chemokine 30 100.00 Very High Very High Very High
Peripheral nerve injury 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 63 100.00 Very High Very High Very High
Nervous System Injury 34 100.00 Very High Very High Very High
Aging 207 99.92 Very High Very High Very High
Cognitive Disorder 242 99.84 Very High Very High Very High
Targeted Disruption 1064 99.76 Very High Very High Very High
Urological Neuroanatomy 362 99.68 Very High Very High Very High
Schizophrenia 103 99.48 Very High Very High Very High
Autoimmune Disease 9 99.40 Very High Very High Very High
Injury 83 99.20 Very High Very High Very High
Anxiety Disorder 190 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used genetically engineered male mice that had their normal NR1 gene knocked out and expressed a modified NR1 gene at either normal level (NR1 +/+, wild type) or at a low level (NR1+/-, knock down).
Gene_expression (expressed) of NR1 associated with targeted disruption
1) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.74 Pain Relevance 0.81
Using western blotting, NR1, NR2A and NR2B subunits were found to be highly expressed in the cerebral cortex and hippocampus of the mouse brain, which are key areas in producing seizures regulated by N-methyl-D-aspartate receptors.
Gene_expression (expressed) of NR1 in brain associated with convulsion, nmda receptor, hippocampus and cerebral cortex
2) Confidence 0.75 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.27 Pain Relevance 0.50
The vector-derived knockdown of NR1 expression in SCDH did not alter acute thermal or mechanical stimulus paw-withdrawal thresholds.
Gene_expression (expression) of NR1 in paw associated with dorsal horn and withdrawal
3) Confidence 0.73 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17551091 Disease Relevance 0.46 Pain Relevance 0.83
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn.
Gene_expression (expression) of NR1 in spinal cord dorsal horn associated with nmda receptor, dorsal horn and spinal cord
4) Confidence 0.73 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17551091 Disease Relevance 0.34 Pain Relevance 0.59
Combined immunogold and immuoperoxidase electron microscopic analysis showed that NR1 was prominently expressed in postsynaptic (i.e., somata, dendrites) locations of CeA neurons, where they were also frequently colocalized with the microOR.
Gene_expression (expressed) of NR1 in CeA associated with amygdala
5) Confidence 0.73 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.31 Pain Relevance 1.29
A spatial-temporal deletion of NR1 in postsynaptic sites of CeA neurons was produced by local microinjection of a neurotropic recombinant adeno-associated virus (rAAV), expressing the green fluorescent protein (GFP) reporter and Cre recombinase (rAAV-GFP-Cre), in adult "floxed" NR1 (fNR1) mice.
Gene_expression (produced) of NR1 in neurons associated with amygdala
6) Confidence 0.73 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.44 Pain Relevance 1.45
We hypothesized that animals deficient in GluRepsilon1, an abundant and ubiquitously postnatally expressed NMDAR subunit, might be resistant to the effects of ketamine.
Gene_expression (expressed) of NMDAR associated with ketamine
7) Confidence 0.68 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385364 Disease Relevance 0.08 Pain Relevance 0.36
We used genetically engineered male mice that had their normal NR1 gene knocked out and expressed a modified NR1 gene at either normal level (NR1 +/+, wild type) or at a low level (NR1+/-, knock down).
Gene_expression (knocked) of NR1 associated with targeted disruption
8) Confidence 0.68 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.73 Pain Relevance 0.81
It is important to point out that besides DA neurons, GABAergic neurons in VTA which provide important regulation to DA neuron also express NMDAR1.
Gene_expression (express) of NMDAR1 in GABAergic neurons associated with ventral tegmentum and gabaergic
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0.08 Pain Relevance 0.84
The expression of NR1 and the composition of the NR2 subunits are developmentally regulated.
Gene_expression (expression) of NR1
10) Confidence 0.67 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.56
The latter study supports the notion that neural activity is a regulating factor for NR1 expression.
Gene_expression (expression) of NR1 in neural
11) Confidence 0.67 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.19
NR1 expression and NR2A/B composition are altered in the rdta retina
Gene_expression (expression) of NR1 in retina
12) Confidence 0.67 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.05
NR1 expression is not altered in the dark-reared visual cortex [24,25] but contrarily, an intraocular injection of tetrodotoxin (TTX) does increase NR1-antibody binding in layer IV of the cortical column driven by the blocked eye [41].
Gene_expression (expression) of NR1 in eye associated with tetrodotoxin
13) Confidence 0.67 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.10
Fig S5 shows synapsin I (presynaptic protein) and NR1 (postsynaptic protein) expression patterns as visualized in WT and PrP-null mature primary hippocampal cultured neurons.
Gene_expression (expression) of NR1 in neurons
14) Confidence 0.65 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
The prolonged current decay kinetics observed in evoked whole cell NMDA currents in PrP-null mice are reminiscent of the slow current waveforms observed upon transient expression of NR1/NR2D receptors in tsA-201 cells (Vicini et al., 1998).
Gene_expression (expression) of NR1
15) Confidence 0.65 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
In conclusion, NT-3 regulates the expression of NMDAR subunits modifying striatal neuronal properties that confers the differential vulnerability to excitotoxicity in projection neurons and interneurons in the striatum.
Gene_expression (expression) of NMDAR in interneurons associated with projection neuron
16) Confidence 0.64 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.05 Pain Relevance 0.21
An in vitro luciferase assay was used to identify candidate and control (inactive) short interfering RNA (siRNA) sequences that are expressed by a recombinant adeno-associated virus (rAAV) plasmid. rAAV vectors targeting the NR1 subunit were prepared that express active or control (mismatch) siRNA sequences and injected into the mouse spinal cord dorsal horn (SCDH).
Gene_expression (targeting) of NR1 in SCDH associated with dorsal horn and spinal cord
17) Confidence 0.63 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17551091 Disease Relevance 0.32 Pain Relevance 0.52
To overcome these shortcomings, high-resolution imaging and molecular pharmacology were used to (1) Identify the ultrastructural localization of the essential NMDA-NR1 receptor (NR1) subunit and its relationship to the mu-opioid receptor (microOR), the major cellular target of abused opioids like morphine, in the CeA and (2) Determine the effect of CeA NR1 deletion on the physical, and particularly, psychological aspects of opioid dependence.
Gene_expression (deletion) of NR1 in CeA associated with addiction, opioid receptor, amygdala, opioid, imagery and morphine
18) Confidence 0.63 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.26 Pain Relevance 1.27
In the present study we used RT-PCR methods on single cells and tissue to compare the expression of NMDAR subunits, NR1, NR2A and NR2B, in the striatum of R6/2 transgenic mice with their wild-type (WT) littermates at three different age groups corresponding to different symptomatic milestones (19-25 days showing no overt evidence of abnormal behavior, 38-45 days at the onset of the overt phenotype and 78-90 days displaying the full behavioral phenotype).
Gene_expression (expression) of NR1 in striatum associated with targeted disruption
19) Confidence 0.63 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.44 Pain Relevance 0.26
The decrease in expression was not associated with any significant change in expression of NR1 or NR2B.
Gene_expression (expression) of NR1
20) Confidence 0.63 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.33 Pain Relevance 0.51

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