INT92518

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 3
Speculated 6
Reported most in Body
Documents 131
Total Number 137
Disease Relevance 65.52
Pain Relevance 80.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
forebrain 20
neurons 15
hippocampus 6
synapses 5
lamina 4
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 3503 100.00 Very High Very High Very High
Hippocampus 347 100.00 Very High Very High Very High
Glutamate 514 99.98 Very High Very High Very High
long-term potentiation 1317 99.92 Very High Very High Very High
Lasting pain 659 99.92 Very High Very High Very High
Inflammation 529 99.88 Very High Very High Very High
Central grey 1006 99.84 Very High Very High Very High
Dorsal horn 512 99.84 Very High Very High Very High
GABAergic 268 99.72 Very High Very High Very High
IPN 213 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1699 99.98 Very High Very High Very High
Pain 1669 99.92 Very High Very High Very High
INFLAMMATION 558 99.88 Very High Very High Very High
Urological Neuroanatomy 1046 99.84 Very High Very High Very High
Inflammatory Pain 213 99.72 Very High Very High Very High
Anxiety Disorder 430 99.64 Very High Very High Very High
Injury 471 99.36 Very High Very High Very High
Neuropathic Pain 412 99.04 Very High Very High Very High
Immunization 15 99.02 Very High Very High Very High
Bone Cancer 50 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC).
Gene_expression (expression) of NR2B in cingulate cortex associated with inflammation and anterior cingulate cortex
1) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.61 Pain Relevance 0.59
Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain.
Gene_expression (overexpression) of NR2B in forebrain associated with targeted disruption and ipn
2) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.56 Pain Relevance 0.44
Genetic enhancement of inflammatory pain by forebrain NR2B overexpression.
Gene_expression (overexpression) of NR2B in forebrain associated with pain and ipn
3) Confidence 0.76 Published 2001 Journal Nat. Neurosci. Section Title Doc Link 11175877 Disease Relevance 0.84 Pain Relevance 0.89
We have demonstrated that inflammation-related pain was selectively increased in mice with forebrain-targeted NR2B overexpression, while physiological or acute pain is not affected [12].
Gene_expression (overexpression) of NR2B in forebrain associated with pain, inflammation and acute pain
4) Confidence 0.76 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.57 Pain Relevance 0.61
For example, peripheral inflammation at one hindpaw in adult mice increased the expression level of NR2B proteins in the ACC [17].
Gene_expression (expression) of NR2B associated with inflammation and anterior cingulate cortex
5) Confidence 0.76 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.68 Pain Relevance 0.56
The down regulation of NR2B expression throughout development is marked by a concomitant change in NMDA receptor function [13].
Gene_expression (expression) of NR2B associated with nmda receptor
6) Confidence 0.76 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.44 Pain Relevance 1.63
Using western blotting, NR1, NR2A and NR2B subunits were found to be highly expressed in the cerebral cortex and hippocampus of the mouse brain, which are key areas in producing seizures regulated by N-methyl-D-aspartate receptors.
Gene_expression (expressed) of NR2B in brain associated with convulsion, nmda receptor, hippocampus and cerebral cortex
7) Confidence 0.74 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.27 Pain Relevance 0.50
In the present study we used RT-PCR methods on single cells and tissue to compare the expression of NMDAR subunits, NR1, NR2A and NR2B, in the striatum of R6/2 transgenic mice with their wild-type (WT) littermates at three different age groups corresponding to different symptomatic milestones (19-25 days showing no overt evidence of abnormal behavior, 38-45 days at the onset of the overt phenotype and 78-90 days displaying the full behavioral phenotype).
Gene_expression (expression) of NR2B in striatum associated with targeted disruption
8) Confidence 0.72 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.44 Pain Relevance 0.26
The decrease in expression was not associated with any significant change in expression of NR1 or NR2B.
Gene_expression (expression) of NR2B
9) Confidence 0.72 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.33 Pain Relevance 0.52
It is quite likely, however, that the increased expression of NMDA receptor genes, especially Grin2b, was a reflection of the growth of new synapses [39].
Gene_expression (expression) of Grin2b in synapses associated with nmda receptor
10) Confidence 0.71 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.39 Pain Relevance 0.29
Western blots show a reduction in phosphorylated-NR1, NR2A, and NR2B subunit protein expression in the amygdala from fear-conditioned animals.
Gene_expression (expression) of NR2B in amygdala associated with anxiety disorder and amygdala
11) Confidence 0.71 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.76 Pain Relevance 0.67
In the neonatal brains, NR2B and NR2D subunits are highly expressed, and over the course of development, they are substituted or replaced by NR2A and NR2C.
Gene_expression (expressed) of NR2B in brains
12) Confidence 0.71 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.08 Pain Relevance 0.73
However, a previous study using genetic overexpression of NR2B subunits indicate the involvement of NMDA NR2B receptor.
Gene_expression (overexpression) of NR2B
13) Confidence 0.71 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.09 Pain Relevance 0.82
Does genetically overexpression of NR2B mimic physiological or pathological conditions?
Gene_expression (overexpression) of NR2B
14) Confidence 0.71 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.97 Pain Relevance 0.92
These findings are in good accord with previous genetic studies that forebrain NR2B overexpression enhanced spatial and fear memory [30].
Gene_expression (overexpression) of NR2B in forebrain associated with anxiety disorder
15) Confidence 0.71 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.63 Pain Relevance 0.39
NR2A and NR2B are highly expressed in the ACC, a forebrain area involved in emotion, memory and pain [21,22].
Gene_expression (expressed) of NR2B in forebrain associated with pain and anterior cingulate cortex
16) Confidence 0.71 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.27 Pain Relevance 0.53
Blunted NMDAR-dependent neuronal plasticity following repeated morphine injection in PSD-93 KO mice is attributed to PSD-93 deletion-induced alterations of NR2A and NR2B postsynaptic expression in dorsal horn and forebrain cortex neurons, but not in cerebellar neurons.
Gene_expression (expression) of NR2B in neurons associated with targeted disruption, dorsal horn and morphine
17) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.74 Pain Relevance 1.22
Painful stimuli potentiate the prefrontal synaptic transmission and induce glutamate NMDA NR2B receptor expression in the ACC.
Gene_expression (expression) of NMDA NR2B receptor in ACC associated with pain, glutamate and anterior cingulate cortex
18) Confidence 0.68 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18410946 Disease Relevance 0.56 Pain Relevance 1.23
We studied the effect of forebrain-targeted overexpression of the NMDA receptor subunit NR2B on the response of mice to tissue injury and inflammation.
Gene_expression (overexpression) of NMDA receptor subunit NR2B in forebrain associated with inflammation, nmda receptor and injury
19) Confidence 0.67 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11175877 Disease Relevance 0.79 Pain Relevance 0.57
Transgenic mice exhibited prominent NR2B expression and enhanced NMDA receptor-mediated synaptic responses in two pain-related forebrain areas, the anterior cingulate cortex and insular cortex, but not in the spinal cord.
Gene_expression (expression) of NR2B in forebrain associated with targeted disruption, pain, nmda receptor, anterior cingulate cortex and spinal cord
20) Confidence 0.67 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11175877 Disease Relevance 0.85 Pain Relevance 0.76

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox