INT92522

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.25
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
heart 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 100.00 Very High Very High Very High
Morphine 9 98.32 Very High Very High Very High
tetrodotoxin 1 98.30 Very High Very High Very High
withdrawal 8 97.96 Very High Very High Very High
antagonist 1 97.58 Very High Very High Very High
Intracerebroventricular 2 96.62 Very High Very High Very High
noradrenaline 5 89.56 High High
Opioid 1 87.56 High High
Hippocampus 4 86.48 High High
Kinase C 5 85.32 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1 94.56 High High
Convulsion 1 81.68 Quite High
Epilepsy 1 71.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PENK is regulated by the c-jun amino-terminal kinase (JNK) signaling pathway, the crucial role of which is involved in the regulation of transcription factors, such as Jun and Fos.
Regulation (involved) of Regulation (regulation) of Fos
1) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.15 Pain Relevance 0.20
Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart.
Regulation (Role) of Regulation (regulation) of Fos in heart associated with narcan, withdrawal and morphine
2) Confidence 0.19 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 16474935 Disease Relevance 0.09 Pain Relevance 1.38
Intracerebroventricular infusion of the N-methyl-D-aspartate antagonist, MK801, decreased, but tetrodotoxin or the mitogen-activated extracellular-regulated kinase inhibitor, PD98059, did not affect Sp-8-Br-cAMPS-induced phosphorylated c-AMP-responsive element binding protein, phosphorylated Elk-1, phosphorylated extracellular-signal-regulated kinase and Fos immunoreactivity.
Neg (not) Regulation (affect) of Regulation (immunoreactivity) of Fos associated with tetrodotoxin, antagonist and intracerebroventricular
3) Confidence 0.03 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.40

General Comments

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