INT9254

Context Info Confidence 0.43 First Reported 1990 Last Reported 2009 Negated 1 Speculated 1 Reported most in Body Documents 23 Total Number 24 Disease Relevance 13.30 Pain Relevance 2.20

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA) cytoplasm (LDHA)

Anatomy Link Frequency blood 1 hepatocytes 1 leucocyte 1 nasal 1 alveolar macrophages 1 LDHA (Homo sapiens)

Pain Link Frequency Relevance Heat lidocaine 11 99.36 Paracetamol 13 99.04 Inflammation 13 93.32 Pain 10 90.80 tetrodotoxin 1 88.52 Angina 3 87.72 cINOD 2 70.44 intrathecal 2 66.00 methotrexate 4 65.04 addiction 2 61.44

Disease Link Frequency Relevance Heat Death 28 100.00 Diuresis 4 99.96 Adult Respiratory Distress Syndrome 21 99.92 Cancer 87 99.82 Pressure And Volume Under Development 7 99.76 Paralysis 5 99.72 Myocardial Infarction 11 99.68 Paroxysmal Nocturnal Hemoglobinuria 316 99.06 Oliguria 5 99.04 Hemolysis 121 98.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Half way through the course of chemotherapy, serum LDH was decreased, the pericardial effusion had disappeared, and the mediastinal mass was reduced in size.

Negative_regulation (decreased) of LDH associated with pressure and volume under development

1) Confidence 0.43 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1405109 Disease Relevance 1.10 Pain Relevance 0.09

This conflicts with previous data where increased glass fiber concentration decreased chemiluminescence and increased LDH in rat alveolar macrophages but major length-dependent effects were evident.

Negative_regulation (decreased) of LDH in alveolar macrophages

2) Confidence 0.43 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1459188 Disease Relevance 0 Pain Relevance 0

Lactate dehydrogenase A subunit (LDH-A) deficiency is an inherited metabolic myopathy of glycolysis.

Negative_regulation (deficiency) of LDH-A associated with muscle disease

3) Confidence 0.42 Published 1995 Journal Intern. Med. Section Abstract Doc Link 7647396 Disease Relevance 0.36 Pain Relevance 0.09

Lactate dehydrogenase A subunit (LDH-A) deficiency is an inherited metabolic myopathy of glycolysis.

Negative_regulation (deficiency) of Lactate dehydrogenase A associated with muscle disease

4) Confidence 0.42 Published 1995 Journal Intern. Med. Section Abstract Doc Link 7647396 Disease Relevance 0.36 Pain Relevance 0.09

Genetic analysis of a family of lactate dehydrogenase A subunit deficiency.

Negative_regulation (deficiency) of lactate dehydrogenase A

5) Confidence 0.42 Published 1995 Journal Intern. Med. Section Title Doc Link 7647396 Disease Relevance 0.37 Pain Relevance 0.09

NM improved the viability of the hepatocytes, lowered the levels of LDH, and increased lidocaine clearance and albumin production in a concentration-dependent manner.

Negative_regulation (lowered) of LDH in hepatocytes associated with lidocaine

6) Confidence 0.41 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10478723 Disease Relevance 0.14 Pain Relevance 0.19

An intensive anti-cancer chemotherapy with VP-16 and CDDP was done with minor response (MR) and the serum tumor marker, LDH and NSE, decreased markedly.

Negative_regulation (decreased) of LDH associated with cancer

7) Confidence 0.40 Published 1994 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8065070 Disease Relevance 0.93 Pain Relevance 0.05

We observed a different dependency on contractile activity between total enzymatic activities of CK, LDH, and AChE, which were substantially reduced after paralysis, and GP and PGAM, which were unchanged.

Negative_regulation (reduced) of LDH associated with paralysis

8) Confidence 0.40 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.41 Pain Relevance 0.09

These variables were then introduced in a logistic regression model that identified 4 independent predictive factors for early death: PS>1, at least one co-morbidity requiring treatment, LDH>1.5×ULN and low protein or albumin levels.

Negative_regulation (introduced) of LDH associated with death

9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715134 Disease Relevance 0.35 Pain Relevance 0

Toxic effects of acetaminophen on Ishikawa cells were determined by measuring loss of cellular lactate dehydrogenase to culture medium.

Negative_regulation (loss) of lactate dehydrogenase associated with paracetamol

10) Confidence 0.22 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.22 Pain Relevance 0.95

In contrast, human nasal explants treated with all other intranasal agents showed rapid reduction in LDH level followed by stabilization suggesting little or no cytotoxicity on the nasal tissue (Figure 5c,d).

Negative_regulation (reduction) of LDH in nasal

11) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765727 Disease Relevance 0.42 Pain Relevance 0

However, fatal outcomes were associated with decreased platelet counts, increased LDH, ARDS, cardiac failure, and lack of antiviral treatment in the bivariate analyses.

Spec (analyses) Negative_regulation (decreased) of LDH in platelet associated with adult respiratory distress syndrome and myocardial infarction

12) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.37 Pain Relevance 0

Correlations between lactate and BE and lactate and bicarbonate decrease, and between both HR and RQ parameters and exercise intensity as measured by BE decrease, were calculated using Spearman’s rank test.

Negative_regulation (decrease) of lactate

13) Confidence 0.11 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0

Mean paired difference between lactate and BE decrease was 0.7 (SD, 0.7) mM, and that between lactate and bicarbonate decrease was 1.4 (SD, 0.9) mM.

Negative_regulation (decrease) of lactate

14) Confidence 0.11 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0

Arterial lactate vs BE decrease and bicarbonate decrease

Negative_regulation (decrease) of lactate

15) Confidence 0.11 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0

The tests evaluated in the present study were all aimed at a submaximal level: lactate level (or BE decrease) at or just above 4 mM (the anaerobic threshold) and not exceeding 8 mM.

Negative_regulation (decrease) of lactate

16) Confidence 0.11 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0

In addition elevated lactate dehydrogenase (LDH) serum levels, and decreased urinary flow confer higher risk of TLS onset (Cairo and Bishop 2004).

Negative_regulation (decreased) of lactate dehydrogenase associated with diuresis and tumor lysis syndrome

17) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 2.06 Pain Relevance 0.07

In addition elevated lactate dehydrogenase (LDH) serum levels, and decreased urinary flow confer higher risk of TLS onset (Cairo and Bishop 2004).

Negative_regulation (decreased) of LDH associated with diuresis and tumor lysis syndrome

18) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 2.04 Pain Relevance 0.07

Like germ line stem cells, similar patterns of cytotoxicity of silver nanoparticles (decrease of mitochondrial function, LDH leakage, and abnormal cell

Negative_regulation (decrease) of LDH in germ line stem cells

19) Confidence 0.06 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809332 Disease Relevance 0.28 Pain Relevance 0

Concentrations of protein and lactate dehydrogenase (LDH) in exudate and exudate leucocyte numbers were significantly reduced in drug-treated horses when data for all sampling times were pooled.

Negative_regulation (reduced) of lactate dehydrogenase in leucocyte

20) Confidence 0.04 Published 1991 Journal Br. Vet. J. Section Abstract Doc Link 1868324 Disease Relevance 0.33 Pain Relevance 0.24

General Comments

This test has worked.