INT92541

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.85
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spike 2
neurons 2
spinal cord 1
superior 1
primary sensory neurons 1
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 23 100.00 Very High Very High Very High
nociceptor 8 100.00 Very High Very High Very High
long-term potentiation 243 99.84 Very High Very High Very High
nMDA receptor 177 99.28 Very High Very High Very High
Spinal cord 82 98.72 Very High Very High Very High
Ultiva 55 97.56 Very High Very High Very High
Sciatic nerve 10 97.24 Very High Very High Very High
central sensitization 37 95.64 Very High Very High Very High
Thermal hyperalgesia 28 95.60 Very High Very High Very High
Calcitonin gene-related peptide 7 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 47 97.20 Very High Very High Very High
Hyperalgesia 84 95.60 Very High Very High Very High
Neuropathic Pain 41 94.16 High High
Anaerobic Bacterial Infections 2 92.80 High High
Inflammatory Pain 7 89.20 High High
Ganglion Cysts 9 86.72 High High
Pain 37 83.52 Quite High
Vibrio Infection 4 80.84 Quite High
Dementia 1 69.80 Quite High
Dyskinesias 1 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical localization and expression of NR2B phosphorylation at Tyr-1472 in spinal cord
Localization (localization) of NR2B in spinal cord associated with spinal cord
1) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.58 Pain Relevance 0.97
The apparent superior preclinical and clinical data for the second and third generation NR2B compounds is likely to reflect subtype selectivity, a unique mode of action and cellular location of the NR2B receptors in the CNS.
Localization (location) of NR2B in superior
2) Confidence 0.72 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 14965239 Disease Relevance 0.34 Pain Relevance 0.10
Thus, the NMDA receptors may still remain functional as the NR2B protein decreases.
Localization (decreases) of NR2B protein associated with nmda receptor
3) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.88 Pain Relevance 0.68
Immunofluorescence with an antibody that recognized NR1 and another that recognized NR2A and NR2B showed that NR1 and NR2B colocalized in 90% of DRG neurons, including most A-fibers (identified by the presence of neurofilament 200 kDa).
Localization (colocalized) of NR2B in neurons
4) Confidence 0.68 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.24
These results provide evidence that both NR2B- and NR2A-NMDARs contribute to LTP induced by spike-timing protocol.


Localization (contribute) of NR2B in spike associated with long-term potentiation
5) Confidence 0.67 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.46
NR2B-NMDARs are required for LTP induced by the spike-timing protocol, but not by the pairing protocol.
Localization (required) of NR2B-NMDARs in spike associated with long-term potentiation
6) Confidence 0.67 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.15 Pain Relevance 0.52
Modulation occurs through phosphorylation of the intracellular portion of NR2B at specific tyrosine residues by signal transduction proteins.
Localization (portion) of NR2B
7) Confidence 0.63 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.39 Pain Relevance 0.70
Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats.
Localization (Localization) of NR2B in primary sensory neurons associated with nociceptor and sciatic nerve
8) Confidence 0.58 Published 2000 Journal Neuroscience Section Title Doc Link 11113318 Disease Relevance 0.19 Pain Relevance 0.67
Size frequency analysis also demonstrated that NR2B subunits were predominantly localized on the small and medium-sized neurons.
Localization (localized) of NR2B in neurons
9) Confidence 0.51 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113318 Disease Relevance 0.23 Pain Relevance 0.43
(reverse); NR2B 5?
Localization (reverse) of NR2B
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0
Using antibodies that selectively label NR1, NR2A, or NR2B subunits, we found that the protein levels of NR1, NR2A, and NR2B subunits were significantly decreased by 10 ┬ÁM UCB treatment for 24 or 48 h (Figure 4).
Localization (levels) of NR2B
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.37

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