INT92542

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.54
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
sensory neuron 1
spinal cord 1
skin 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 17 100.00 Very High Very High Very High
Calcium channel 3 99.74 Very High Very High Very High
Trigeminal ganglion neurons 1 99.16 Very High Very High Very High
TRP channel 38 98.48 Very High Very High Very High
ASIC 3 98.36 Very High Very High Very High
Dorsal horn 2 98.16 Very High Very High Very High
imagery 11 97.62 Very High Very High Very High
Spinal cord 5 97.52 Very High Very High Very High
dorsal root ganglion 9 93.52 High High
Pain 22 92.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 37 99.00 Very High Very High Very High
Pain 22 92.48 High High
Hyperalgesia 1 75.56 Quite High
Nervous System Injury 1 74.16 Quite High
Peripheral Neuropathy 1 63.48 Quite High
Injury 1 63.04 Quite High
Disease 1 59.08 Quite High
Neuropathic Pain 4 57.72 Quite High
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no significant decrease in TRPV2 immunoreactivity, suggesting that TRPV2 is endogenous to the spinal cord.
Neg (no) Negative_regulation (decrease) of TRPV2 in spinal cord associated with spinal cord
1) Confidence 0.59 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.88 Pain Relevance 0.87
Thirty-seven per cent of the trigeminal ganglion neurons retrogradely labeled from the tooth pulp exhibited VRL-1 immunoreactivity, while the immunoreactivity was detected in only 9% of those labeled from the skin.
Negative_regulation (exhibited) of VRL-1 in skin associated with ganglion cysts and trigeminal ganglion neurons
2) Confidence 0.39 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113320 Disease Relevance 0.25 Pain Relevance 0.26
We conclude that the decrease in PIP(2) levels on channel activation underlies a major component of Ca(2+)-dependent desensitization of TRPV2 and may play a similar role in other TRP channels.
Negative_regulation (desensitization) of TRPV2 associated with trp channel
3) Confidence 0.36 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.05 Pain Relevance 0.15
Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate.
Negative_regulation (desensitization) of TRPV2
4) Confidence 0.36 Published 2010 Journal J. Neurosci. Section Title Doc Link 20926660 Disease Relevance 0.09 Pain Relevance 0.12
Simultaneous confocal imaging and electrophysiological recording of cells expressing TRPV2 and a fluorescent PIP(2)-binding probe demonstrated that TRPV2 desensitization was concomitant with depletion of PIP(2).
Negative_regulation (desensitization) of TRPV2 associated with imagery
5) Confidence 0.36 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.06 Pain Relevance 0.15
TRPV2 desensitization was not altered in whole-cell recordings in the presence of calmodulin inhibitors or on coexpression of mutant calmodulin but was sensitive to changes in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)), suggesting a role of membrane PIP(2) in TRPV2 desensitization.
Negative_regulation (desensitization) of TRPV2
6) Confidence 0.36 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.08 Pain Relevance 0.12
Citral inhibition of agonist-evoked TRPV1, TRPV2, TRPV3, and TRPM8 currents was essentially irreversible (Fig. 2A, D).
Negative_regulation (inhibition) of TRPV2 associated with agonist
7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.08
At low micromolar levels, NMB-1 shows no activity at ASICs, TRPV1, TRPA1 or voltage-gated sodium, potassium or calcium channels, whilst the inhibitor of stretch-activated ion channels GsMTx-4 had no effect on sensory neuron mechanically activated currents.
Negative_regulation (inhibitor) of stretch-activated in sensory neuron associated with calcium channel and asic
8) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.13 Pain Relevance 0.40

General Comments

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