INT92547

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
paw 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 5 100.00 Very High Very High Very High
Spinal cord 57 99.56 Very High Very High Very High
Central nervous system 1 98.08 Very High Very High Very High
Neuropathic pain 22 98.04 Very High Very High Very High
Pain 10 97.80 Very High Very High Very High
Inflammation 5 97.32 Very High Very High Very High
Dorsal horn neuron 3 73.36 Quite High
Sciatic nerve 77 57.52 Quite High
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 55 98.48 Very High Very High Very High
INFLAMMATION 5 97.32 Very High Very High Very High
Targeted Disruption 98 93.44 High High
Nociception 9 91.88 High High
Nervous System Injury 32 5.00 Very Low Very Low Very Low
Hyperalgesia 17 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a first set of experiments, we assessed the influence of NOS1 or NOS2 deletion in the development and expression of peripheral neuropathic pain.
Regulation (influence) of Localization (deletion) of NOS1 associated with neuropathic pain
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.36 Pain Relevance 0.20
The present immunohistochemical study details localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in lumbar spinal cord before and after induction of a painful paw inflammation in mice.
Regulation (regulation) of Localization (localization) of neuronal nitric oxide synthase in paw associated with pain, inflammation, spinal cord and neuronal nitric oxide synthase
2) Confidence 0.39 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.26 Pain Relevance 0.50

General Comments

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