INT92555

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 1.68
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 3
liver 1
skeletal muscle 1
xn (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 7 99.58 Very High Very High Very High
Opioid 3 98.88 Very High Very High Very High
narcan 2 98.56 Very High Very High Very High
antagonist 2 94.00 High High
tail-flick 2 76.56 Quite High
Dopamine 2 75.00 Quite High
Antinociceptive 2 75.00 Quite High
Intracerebroventricular 1 67.52 Quite High
anesthesia 8 18.72 Low Low
vagus nerve 8 18.64 Low Low
Disease Link Frequency Relevance Heat
Disease 200 99.14 Very High Very High Very High
Diabetes Mellitus 144 95.56 Very High Very High Very High
Insulin Resistance 40 85.28 High High
Apoptosis 120 84.12 Quite High
Obesity 8 77.96 Quite High
Death 32 67.68 Quite High
Drug Induced Neurotoxicity 8 55.00 Quite High
Aging 16 45.16 Quite Low
Neurodegenerative Disease 8 43.36 Quite Low
Parkinson's Disease 8 23.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analgesic activity of [Ser(1)]HN (50 nmol/mouse) was not affected by the coadministration of opioid (naloxone, 1 nmol/mouse), NMDA (CPP, 0.3 and MK-801, 0.3 nmol/mouse) and D(1) (SCH-23390, 0.5 nmol/mouse) receptor antagonists, but it was significantly antagonized by the coinjection of the D(2) receptor antagonist raclopride (0.5 nmol/mouse).
Neg (not) Regulation (affected) of HN associated with antagonist, analgesic, narcan and opioid
1) Confidence 0.22 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11113487 Disease Relevance 0 Pain Relevance 1.05
This suggests that the effect of peripherally administered HN analog on hepatic insulin action is through the hypothalamus, while the effects on skeletal muscle are due to both central and direct actions.


Regulation (effect) of HN in skeletal muscle
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
In addition, we assessed the effects of DD HN on glucose metabolism since dimerization is an essential step in the cytoprotective effects of HN [27].
Regulation (effects) of HN
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
To examine the role of the hypothalamus in mediating the effects of peripherally administered HN analogue, we infused HNGF6A peripherally in the presence of hypothalamic inhibition of STAT-3 and studied glucose fluxes under insulin clamps.
Regulation (effects) of HN in hypothalamus
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Indeed, when STAT-3 signaling was inhibited in the hypothalamus, the effects of peripherally administered HN analog on liver was completely abolished, once again emphasizing the role of the hypothalamus in mediating the hepatic effects of HN and its analogues.
Regulation (effects) of HN in liver
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.33 Pain Relevance 0
Effects of the potent HN analog, HNGF6A on hepatic insulin sensitivity are mediated through the hypothalamus
Regulation (Effects) of HN in hypothalamus
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Furthermore, we show that the effects of HN on glucose metabolism are tempered by binding of HN to IGFBP-3 in the hypothalamus, as central infusion of a non-IGFBP-3 binding analog, F6AHN, resulted in a more potent effect on insulin action than HN.
Regulation (effect) of HN in hypothalamus
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.08 Pain Relevance 0
We also examined if there were changes in the levels of HN in circulation and in tissues with age.


Regulation (changes) of HN
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.45 Pain Relevance 0
Based upon the link of HN with two age-related diseases, we examined if there were age associated changes in HN levels.
Regulation (changes) of HN associated with disease
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.81 Pain Relevance 0

General Comments

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