INT9256

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 16.44
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELPLG) plasma membrane (SELPLG)
Anatomy Link Frequency
T cells 7
leukocyte 2
fat 2
lymphocyte 2
stem cells 2
SELPLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 128 99.68 Very High Very High Very High
chemokine 80 99.64 Very High Very High Very High
Arthritis 124 99.32 Very High Very High Very High
Angina 10 97.64 Very High Very High Very High
cytokine 34 92.16 High High
Inflammatory response 5 82.56 Quite High
Multiple sclerosis 56 81.96 Quite High
psoriasis 133 81.04 Quite High
tolerance 29 81.00 Quite High
metalloproteinase 1 79.48 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 150 100.00 Very High Very High Very High
Adhesions 94 100.00 Very High Very High Very High
Thrombosis 6 99.76 Very High Very High Very High
INFLAMMATION 133 99.68 Very High Very High Very High
Eczema 58 99.44 Very High Very High Very High
Seronegative Spondarthritis 98 99.32 Very High Very High Very High
Heart Disease 17 98.96 Very High Very High Very High
Arthritis 30 98.94 Very High Very High Very High
Myocardial Infarction 18 98.76 Very High Very High Very High
Cv General 3 Under Development 10 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thymic nurse cells (TNCs) display a neuroendocrine cell specific immunophenotype (IP): Thy-1+, A2B5+, TT+, TE4+, UJ13/A+, UJ127.11+, UJ167.11+, UJ181.4+, and presence of common leukocyte antigen (CLA+).
Gene_expression (presence) of CLA in nurse cells
1) Confidence 0.75 Published 1999 Journal In Vivo Section Abstract Doc Link 10459506 Disease Relevance 0 Pain Relevance 0
The thymic nurse cells (TNCs) display a neuroendocrine cell specific immunophenotype (IP): Thy-1+, A2B5+, TT+, TE4+, UJ13/A+, UJ127.11+, UJ167.11+, UJ181.4+, and presence of common leukocyte antigen (CLA+).
Gene_expression (presence) of CLA in neuroendocrine cell
2) Confidence 0.75 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0
On the other hand, cutaneous leukocyte antigen (CLA) was abundantly detected in the inflammatory cells in the lesional skin, although less expressed in the synovium.
Gene_expression (detected) of CLA in leukocyte associated with inflammation
3) Confidence 0.75 Published 2005 Journal J. Dermatol. Section Abstract Doc Link 15906536 Disease Relevance 0.78 Pain Relevance 0.57
There was a significant correlation between the detection of IgG CLa in patients with a history of myocardial infarction and the presence of left ventricular intracavitary thrombosis.
Gene_expression (detection) of CLa associated with thrombosis and myocardial infarction
4) Confidence 0.58 Published 1992 Journal Kardiologiia Section Abstract Doc Link 1405256 Disease Relevance 0.95 Pain Relevance 0.44
The levels of IgG CLa were increased in 78% of patients with history of MI and in 32% without MI history.
Gene_expression (levels) of CLa
5) Confidence 0.58 Published 1992 Journal Kardiologiia Section Abstract Doc Link 1405256 Disease Relevance 0.95 Pain Relevance 0.42
The results demonstrated a significant decrease in BFM in both the CLA-FFA and CLA-triacylglycerol groups compared to placebo (?
Gene_expression (groups) of CLA
6) Confidence 0.25 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.81 Pain Relevance 0
The results demonstrated a significant decrease in BFM in both the CLA-FFA and CLA-triacylglycerol groups compared to placebo (?
Gene_expression (groups) of CLA
7) Confidence 0.25 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.81 Pain Relevance 0
Recently, we showed that another unusual PUFA, conjugated linoleic acid (CLA), with peculiar biological activities [15], widely present in our diet because relatively abundant in dairy products, is preferentially beta oxidized in peroxisomes in experimental animals and humans [16].
Gene_expression (oxidized) of CLA
8) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.13 Pain Relevance 0.07
In fact, as we recently demonstrated [20], CD133+ stem cells express several adhesion molecules, such as CD44, LFA-1, PSGL-1, ?
Gene_expression (express) of PSGL-1 in stem cells associated with adhesions
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 1.02 Pain Relevance 0.09
In fact, as we recently demonstrated [20], CD133+ stem cells express several adhesion molecules, such as CD44, LFA-1, PSGL-1, ?
Gene_expression (adhesion) of PSGL-1 in stem cells associated with adhesions
10) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 1.02 Pain Relevance 0.09
For example, cutaneous lymphocyte associated (CLA) antigen, an adhesion molecule that identifies lymphocytes that preferentially traffic to the skin, is upregulated on lymphocytes in psoriatic skin but is minimally expressed on cells in the PsA synovium [36].


Gene_expression (expressed) of CLA in lymphocytes associated with psoriasis, adhesions and arthritis
11) Confidence 0.16 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.30 Pain Relevance 0.52
The expression of cutaneous leukocyte antigen (CLA) and CC-chemokine receptor 4 (CCR4; associated with skin-homing) as well as the expression of integrin ?
Gene_expression (expression) of CLA in leukocyte associated with chemokine
12) Confidence 0.12 Published 2006 Journal BMC Immunol Section Abstract Doc Link PMC1539023 Disease Relevance 0.35 Pain Relevance 0.18
Flow cytometry was used to determine the expression of CLA and integrin ?
Spec (determine) Gene_expression (expression) of CLA
13) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.41 Pain Relevance 0.04
Interestingly, T cells isolated from the small intestines and the skin are almost completely dichotomous in their expression of trafficking determinants; T cells from the skin express cutaneous leukocyte antigen (CLA) and CCR4, but lack integrin ?
Gene_expression (express) of CLA in T cells
14) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.14 Pain Relevance 0.04
Since many trafficking determinants are differentially expressed on naïve and memory T cells and CSF contains predominantly CD4+ T cells, of which almost all display a phenotype consistent with previously activated memory cells [18], we compared the expression of CLA and integrin ?
Gene_expression (expression) of CLA in T cells
15) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.35 Pain Relevance 0.03
It is well established that T cells isolated from the small intestines and the skin are nearly homogenously positive for mutually exclusive pairs of trafficking determinants; almost all T cells from the skin express CLA and CCR4, but lack integrin ?
Gene_expression (express) of CLA in T cells
16) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.14 Pain Relevance 0.04
It is plausible that additional tissue-committed T cell populations exist, since T cells from most other tissue compartments, including bronchoalveolar lavage (BAL) fluid and liver, do not express CLA, integrin ?
Neg (not) Gene_expression (express) of CLA in T cells
17) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.24 Pain Relevance 0.08
Analogous to the present observations, synovial fluid from patients with arthritis contained comparable numbers of CD4+ memory T cells expressing CLA, integrin ?
Gene_expression (expressing) of CLA in memory T cells associated with arthritis
18) Confidence 0.12 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.40 Pain Relevance 0.13
Furthermore, the expression of Sp110 and PSGL-1 were shown to be silenced by 85 ± 9% and 61 ± 18% (P < 0.05; N = 8), respectively when compared to ARP3 siRNA-nucleofected controls.
Gene_expression (expression) of PSGL-1
19) Confidence 0.12 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.38 Pain Relevance 0
After completion of pre-training testing, subjects were then randomized to either a combination of CrM and CLA (CrM+CLA) (5 g CrM (Neotine®)+2 g dextrose/d, Palo Alta, CA); and 6 g of CLA (CLA-ONE® 45% c9, t11; 45% t10, c12, Pharmanutrients, Gurnee, IL) or placebo (PL) (7 g dextrose/d+6 g of safflower oil/d) for 24 weeks.
Gene_expression (combination) of CLA
20) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.07 Pain Relevance 0

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