INT92571

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 4.80
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) cytoplasm (Mapk7)
Anatomy Link Frequency
dorsal root ganglion 2
spinal 1
neurons 1
paw 1
spinal cord 1
Mapk7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 2 100.00 Very High Very High Very High
sodium channel 7 99.84 Very High Very High Very High
Analgesic 2 99.58 Very High Very High Very High
Neuropathic pain 6 97.88 Very High Very High Very High
nociceptor 4 97.88 Very High Very High Very High
Root ganglion neuron 4 97.72 Very High Very High Very High
qutenza 6 96.72 Very High Very High Very High
Hyperalgesia 28 96.08 Very High Very High Very High
Peripheral nerve injury 3 95.76 Very High Very High Very High
Inflammation 21 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 14 99.98 Very High Very High Very High
Pressure And Volume Under Development 2 99.24 Very High Very High Very High
Neuropathic Pain 10 97.88 Very High Very High Very High
Ganglion Cysts 16 97.40 Very High Very High Very High
Hyperalgesia 42 96.08 Very High Very High Very High
INFLAMMATION 17 95.68 Very High Very High Very High
Nervous System Injury 7 95.32 Very High Very High Very High
Pain 24 95.20 Very High Very High Very High
Hypersensitivity 29 81.76 Quite High
Inflammatory Pain 13 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results strongly suggested that the dynamic modulation of BmK I on sodium channels located in peripheral primary afferent neurons, especially in capsaicin-sensitive neurons, mediated pain sensation.
Regulation (modulation) of BmK I in neurons associated with pain, qutenza and sodium channel
1) Confidence 0.54 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20736005 Disease Relevance 0.76 Pain Relevance 1.24
In contrast, PWL was enhanced to about 177 +/- 16%, 141 +/- 15% and 133 +/- 15% of the control at the same applied concentrations of BmK IT2 in normal rats.
Regulation (control) of BmK IT2
2) Confidence 0.44 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 11113589 Disease Relevance 0.35 Pain Relevance 0.56
In this study, the suppressive effects of BmK IT2, a kind of Na+ channel-specific modulator from the venom of the scorpion Buthus martensi Karsch, on biphasic nociceptive behavior in rats and c-Fos expression in rat spinal cord induced by formalin were investigated.
Spec (investigated) Regulation (effects) of BmK IT2 in spinal cord associated with nociception and spinal cord
3) Confidence 0.41 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 13130519 Disease Relevance 0.17 Pain Relevance 0.08
The results suggested that peripheral administration of BmK I could evoke a profound change of spinal neuronal activities manifested as specific patterns of c-Fos expression, which may be partially attributed to the selective modulation of BmK I on voltage-gated Na+ channels located in peripheral nociceptors.
Regulation (modulation) of BmK I in nociceptors associated with nociceptor
4) Confidence 0.24 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14554105 Disease Relevance 0 Pain Relevance 0.26
The anti-nociceptive effect of BmK AS, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated Na+ currents in primary afferent neurons.
Regulation (effect) of BmK in afferent neurons associated with nociception and analgesic
5) Confidence 0.20 Published 2006 Journal Peptides Section Title Doc Link 16716457 Disease Relevance 0.27 Pain Relevance 0.34
Within the past decade, several studies in rodents have elucidated the roles of ERK, p38, JNK and ERK5 in generating nociceptive sensitivity and nociceptive plasticity.
Regulation (roles) of ERK5 associated with nociception
6) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 0.84 Pain Relevance 0.49
Moreover, minocycline partially inhibited BmK venom-induced spinal c-Fos expression but lack of effects on BmK venom-induced paw edema.
Regulation (effects) of BmK in paw associated with pressure and volume under development
7) Confidence 0.09 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19782067 Disease Relevance 0.59 Pain Relevance 0.60
The modulation effects of BmK I, an alpha-like scorpion neurotoxin, on voltage-gated Na(+) currents in rat dorsal root ganglion neurons.
Regulation (effects) of BmK I in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
8) Confidence 0.07 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 16129561 Disease Relevance 0.35 Pain Relevance 0.34
The present study investigated the effects of BmK I, a Na(+) channel receptor site 3 modulator purified from the Buthus martensi Karsch (BmK) venom, on the voltage-gated sodium currents in dorsal root ganglion (DRG) neurons.
Spec (investigated) Regulation (effects) of BmK I in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
9) Confidence 0.07 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16129561 Disease Relevance 0.34 Pain Relevance 0.33
Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain.
Regulation (Roles) of extracellular signal-regulated protein kinases 5 in spinal associated with neuralgia and neuropathic pain
10) Confidence 0.06 Published 2007 Journal J. Neurochem. Section Title Doc Link 17509087 Disease Relevance 1.13 Pain Relevance 1.00

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