INT92572

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.71
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) cytoplasm (Mapk7)
Anatomy Link Frequency
neuronal 3
spinal cord 3
dorsal horn 2
nociceptor 2
spinal 1
Mapk7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 41 100.00 Very High Very High Very High
intrathecal 12 100.00 Very High Very High Very High
qutenza 5 99.90 Very High Very High Very High
Spinal cord 15 99.56 Very High Very High Very High
Spontaneous pain 2 99.52 Very High Very High Very High
antinociception 1 98.68 Very High Very High Very High
Hyperalgesia 7 98.24 Very High Very High Very High
nociceptor 4 97.88 Very High Very High Very High
Lasting pain 2 96.96 Very High Very High Very High
Dorsal horn 2 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 19 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 100.00 Very High Very High Very High
Nociception 12 99.76 Very High Very High Very High
Hyperalgesia 9 98.24 Very High Very High Very High
INFLAMMATION 2 91.68 High High
Hypersensitivity 2 90.28 High High
Inflammatory Pain 3 83.64 Quite High
Neuropathic Pain 18 77.60 Quite High
Ganglion Cysts 1 64.72 Quite High
Complex Regional Pain Syndromes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of phosphorylated ERK5 (pERK5), pCREB, were assessed by both Western blotting and immunohistochemical analysis.
Gene_expression (Expressions) of ERK5
1) Confidence 0.78 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.08 Pain Relevance 0
The results thus suggest that BmK IT2 can produce peripheral antihyperalgesia and antinociception, which might be attributed a pathway of modulating the sodium channels on nociceptor.
Gene_expression (produce) of BmK IT2 in nociceptor associated with antinociception, nociceptor and sodium channel
2) Confidence 0.75 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 11113589 Disease Relevance 0.33 Pain Relevance 0.57
The time courses of pERK5 expression showed that the levels of both cytosol and nuclear pERK5 were increased at all points after CCI and reached a peak level on post-operative day 5.
Gene_expression (expression) of pERK5
3) Confidence 0.68 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.06 Pain Relevance 0
CCI significantly increased the expression of pERK5 neurons in the ipsilateral spinal dorsal horn to injury, not in the contralateral spinal dorsal horn.
Gene_expression (expression) of pERK5 in dorsal horn
4) Confidence 0.68 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.07 Pain Relevance 0
Expressions of phosphorylated ERK5 (pERK5), pCREB, were assessed by both Western blotting and immunohistochemical analysis.
Gene_expression (Expressions) of pERK5
5) Confidence 0.68 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.08 Pain Relevance 0
CCI significantly increased the expression of pERK5 neurons in the laminae I and II of ipsilateral spinal dorsal horn to injury, not in the contralateral spinal dorsal horn.
Gene_expression (expression) of pERK5 in dorsal horn
6) Confidence 0.68 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0.05 Pain Relevance 0
Intrathecal injection AS-ODN markedly suppressed the increase of CCI-induced pERK5, pCREB expression in the spinal cord.
Gene_expression (expression) of pERK5 in spinal cord
7) Confidence 0.68 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0 Pain Relevance 0
Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.
Gene_expression (Suppression) of BmK in spinal associated with pain, spontaneous pain and intrathecal
8) Confidence 0.67 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17562390 Disease Relevance 0.19 Pain Relevance 0.51
BmK AS, a polypeptide from BmK venom, could produce peripheral potent anti-nociceptive effects in rats.
Gene_expression (produce) of BmK AS associated with nociception
9) Confidence 0.66 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18343613 Disease Relevance 0.27 Pain Relevance 0.13
The results suggested that peripheral administration of BmK I could evoke a profound change of spinal neuronal activities manifested as specific patterns of c-Fos expression, which may be partially attributed to the selective modulation of BmK I on voltage-gated Na+ channels located in peripheral nociceptors.
Gene_expression (modulation) of BmK I in nociceptors associated with nociceptor
10) Confidence 0.60 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14554105 Disease Relevance 0 Pain Relevance 0.26
In this paper, the central neuronal activities elicited by BmK I, a specific voltage-gated Na+ channel modulator, were examined by monitoring the c-Fos expression pattern of rat spinal cord. c-Fos protein in laminae I-II, V-VI, and VII-X could be detected at 0.5 h, increased steadily at 1 h, reached a peak at 2 h, and then decreased rapidly from 4 to 24 h after Bmk I was subcutaneously injected into the rat hind paw.
Gene_expression (expression) of BmK I in neuronal associated with spinal cord
11) Confidence 0.60 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14554105 Disease Relevance 0 Pain Relevance 0.09
CONCLUSION: The present study demonstrates that BmK AS is capable of producing remarkable anti-nociceptive effects not only in periphery but also in spinal cord.


Gene_expression (producing) of BmK AS in spinal cord
12) Confidence 0.59 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18343613 Disease Relevance 0.12 Pain Relevance 0
The dramatic attenuation by pretreatment with resiniferatoxin (RTX), an ultrapotent analog of capsaicin, on BmK I-induced pain-related behaviors, paw edema, and spinal L4-L5 c-Fos expression demonstrated that capsaicin-sensitive primary afferent neurons played important roles in pain induced by BmK I.
Gene_expression (expression) of BmK I in afferent neurons associated with pain, pressure and volume under development and qutenza
13) Confidence 0.59 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20736005 Disease Relevance 0.93 Pain Relevance 1.25
Intrathecal injection of l-NAME could also partially inhibit BmK venom-induced c-Fos expression in lumbar spinal cord at 2 h.
Gene_expression (expression) of BmK in spinal cord associated with spinal cord and intrathecal
14) Confidence 0.23 Published 2008 Journal Toxicon Section Abstract Doc Link 18606430 Disease Relevance 0.42 Pain Relevance 0.63
The results showed that the number of neuronal NO synthase (nNOS) positive neurons significantly increased in superficial (I-II), deep (V-VI) dorsal horn laminae and the ventral gray laminae (VII-X), but not in the nucleus proprius (III and IV) of bilateral L4-L5 lumbar spinal cord after unilateral intraplantar injection of BmK venom from 2h to 7d.
Gene_expression (injection) of BmK in neuronal associated with dorsal horn and spinal cord
15) Confidence 0.17 Published 2008 Journal Toxicon Section Abstract Doc Link 18606430 Disease Relevance 0.33 Pain Relevance 0.43
Moreover, minocycline partially inhibited BmK venom-induced spinal c-Fos expression but lack of effects on BmK venom-induced paw edema.
Gene_expression (expression) of BmK in paw associated with pressure and volume under development
16) Confidence 0.17 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19782067 Disease Relevance 0.60 Pain Relevance 0.61
Using two-electrode voltage-clamp recording, we studied the efficacy and selectivity of BmK I to three neuronal VGSCs co-expressed with the auxiliary ?
Gene_expression (co-expressed) of BmK I in neuronal
17) Confidence 0.13 Published 2010 Journal Biochem. J. Section Abstract Doc Link 20678086 Disease Relevance 0.18 Pain Relevance 0.28

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