INT92581

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Context Info
Confidence 0.09
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IGF1R, PTGER2) signal transduction (IGF1R) signal transducer activity (PTGER2)
Anatomy Link Frequency
Caco-2 4
IGF1R (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 99.86 Very High Very High Very High
cINOD 2 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 8 99.32 Very High Very High Very High
INFLAMMATION 2 97.68 Very High Very High Very High
Apoptosis 2 53.72 Quite High
Cancer 2 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that COX-2 expression and PGE2 synthesis are up-regulated by an IGF-II/IGF-I receptor autocrine pathway in Caco-2 colon carcinoma cells.
IGF-I receptor Positive_regulation (up-regulated) of Gene_expression (synthesis) of PGE2 in Caco-2 associated with colon cancer
1) Confidence 0.09 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.36 Pain Relevance 0.09
IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells.
IGF-I receptor Positive_regulation (up-regulates) of Gene_expression (synthesis) of PGE2 in Caco-2 associated with colon cancer and cox2
2) Confidence 0.09 Published 2000 Journal Oncogene Section Title Doc Link 11114729 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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