INT92588

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.20
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
Anatomy Link Frequency
DA neurons 1
Caco-2 1
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 108 99.00 Very High Very High Very High
Dopamine 166 98.56 Very High Very High Very High
Bioavailability 1 98.12 Very High Very High Very High
metalloproteinase 1 84.40 Quite High
pain pelvic 2 76.52 Quite High
midbrain 40 71.72 Quite High
cINOD 1 62.28 Quite High
Somatostatin 4 42.32 Quite Low
COX2 1 25.00 Low Low
Action potential 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 138 99.00 Very High Very High Very High
Cancer 55 98.86 Very High Very High Very High
Hypoglycemia 57 98.78 Very High Very High Very High
Gastrointestinal Stromal Tumor 81 95.04 Very High Very High Very High
Apoptosis 7 91.84 High High
Islet Cell Adenoma 12 87.76 High High
Fibrosarcoma 3 86.68 High High
Disease 23 85.72 High High
Pituitary Cancer 39 82.52 Quite High
Ovarian Cancer 15 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization of the tumor samples demonstrated high expression of IGF II mRNA and elevated pro-IGF II (figure 3).
Positive_regulation (elevated) of pro-IGF II associated with cancer
1) Confidence 0.58 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.55 Pain Relevance 0
Consequently, Hizuka et al. demonstrated that IGF I was always low in hypoglycemic patients with "big" IGF II, while those without elevated "big" IGF II had both low IGF I and II [27].
Neg (without) Positive_regulation (elevated) of IGF II
2) Confidence 0.48 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.67 Pain Relevance 0
A landmark observation by Teale et al. was that IGF I and II levels in patients with hyperinsulinemic hypoglycemia were both usually low, while patients with NICTH had normal levels of IGF II [25].
Positive_regulation (levels) of IGF II associated with hypoglycemia
3) Confidence 0.42 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.74 Pain Relevance 0
Also, the blockade of the PI3-kinase, that mediates the proliferative effect of IGF-I receptor in Caco-2 cells, inhibits IGF-II-dependent COX-2 up-regulation and PGE2 synthesis.
Positive_regulation (up-regulation) of IGF-II in Caco-2
4) Confidence 0.33 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.45 Pain Relevance 0.06
IGF2, ACTN4, AXL, and SHC1 were among the most upregulated genes.
Positive_regulation (upregulated) of IGF2
5) Confidence 0.33 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 1.28 Pain Relevance 0.47
The combination of the four factors SDF-1, PTN, IGF2, and EFNB1 was therefore termed “SPIE”.
Positive_regulation (termed) of IGF2
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.14
The four factors SDF-1, PTN, IGF2, and EFNB1 were sufficient to induce hESC to differentiate to DA neurons.


Positive_regulation (sufficient) of IGF2 in DA neurons associated with dopamine
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.06 Pain Relevance 0.31
Up to 90% of circulating IGF-I and IGF-II are carried by binding to either IGFBP-3 or IGFBP-5.
Positive_regulation (circulating) of IGF-II
8) Confidence 0.08 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.46 Pain Relevance 0.09

General Comments

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