INT92589

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.98
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
Caco-2 1
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 77.52 Quite High
alcohol 1 72.28 Quite High
COX2 1 25.00 Low Low
Mechanotransduction 1 7.88 Low Low
Inflammation 29 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Codeine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 100.00 Very High Very High Very High
Colon Cancer 5 90.56 High High
Renal Cell Carcinoma 29 90.40 High High
Adhesions 3 88.96 High High
Breast Cancer 24 84.12 Quite High
INFLAMMATION 30 77.28 Quite High
Disease 14 63.08 Quite High
Apoptosis 4 60.72 Quite High
Soft Tissue Injuries 2 60.16 Quite High
Cancer 101 54.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of COX-2 expression by IGF-II is mediated through activation of IGF-I receptor because: (i) treatment of Caco-2 cells with a blocking antibody to the IGF-I receptor inhibits COX-2 mRNA expression; (ii) transfection of Caco-2 cells with a dominant negative IGF-I receptor reduces COX-2 expression and activity.
Positive_regulation (activation) of IGF-I receptor in Caco-2
1) Confidence 0.38 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.38 Pain Relevance 0.08
Results for EGFR, pERBB2, FOXA1 and IGF1R status were scored by the quick score (QS) [32], taking into account the percentage (P) and intensity (I) of immunostaining (QS = P × I varies from 0 to 300) except for ERBB2 status (defined with ERBB2 TAB250 or HercepTest kit), which was evaluated with the Dako scale (0-3+, HercepTest kit scoring guidelines).
Positive_regulation (Results) of IGF1R
2) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.08 Pain Relevance 0.04
Moreover, one possible link in the molecular mechanism playing a role in increased matrix organization and collagen expression may be signals associated with IGF-I receptor signaling as indicated by increased IGFR levels in treated animals.
Positive_regulation (increased) of IGFR
3) Confidence 0.26 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.20 Pain Relevance 0
Another mechanism of resistance involves increased insulin growth factor-1 receptor (IGF-1R)/PI3K/AKT signaling as a result of loss of mTOR/S6K inhibition whilst on therapy which limits the antitumor effect of mTOR inhibitors.
Positive_regulation (increased) of IGF-1R associated with hyperinsulinism
4) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.31 Pain Relevance 0

General Comments

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