INT92592

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.52
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
mammary glands 1
d cells 1
Caco-2 1
eosinophil 1
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 98.92 Very High Very High Very High
cINOD 34 98.00 Very High Very High Very High
Inflammation 80 87.88 High High
Inflammatory stimuli 4 53.04 Quite High
Osteoarthritis 105 47.60 Quite Low
agonist 1 35.36 Quite Low
cytokine 77 15.68 Low Low
corticosteroid 1 14.72 Low Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
COX-2 inhibitor 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 88 99.64 Very High Very High Very High
Colon Cancer 16 99.08 Very High Very High Very High
Infection 104 98.72 Very High Very High Very High
Herpes Simplex Virus 238 98.60 Very High Very High Very High
INFLAMMATION 99 97.28 Very High Very High Very High
Disease 27 95.16 Very High Very High Very High
Chronic Sinusitis 24 84.16 Quite High
Nasal Polyps 24 82.32 Quite High
Targeted Disruption 20 76.84 Quite High
Rhinitis 16 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is on line with our findings however, mRNA levels of EP2 and EP4 receptors did not correlate with eosinophil number or eosinophil activation markers but it was increased in the disease groups compared to controls.
Transcription (levels) of EP2 in eosinophil associated with disease
1) Confidence 0.32 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.31 Pain Relevance 0.24
COX-2 mRNA and PGE2 levels are higher in proliferating cells compared with post-confluent differentiated cells and in cells that constitutively overexpress IGF-II.
Transcription (levels) of PGE2
2) Confidence 0.13 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.35 Pain Relevance 0.09
IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells.
Transcription (expression) of PGE2 in Caco-2 associated with colon cancer and cox2
3) Confidence 0.11 Published 2000 Journal Oncogene Section Title Doc Link 11114729 Disease Relevance 0.43 Pain Relevance 0.15
The concentration of PGE2, IL-10 and IL-18 was determined in culture medium of confluent cells incubated for their last 48 hours in Ham's F12/DMEM containing 1% ITS.
Transcription (concentration) of PGE2
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0 Pain Relevance 0
Though there was induction in PGE2 levels in si-COX-2 transduced cells upon KSHV infection, this induction was lower than in si-C-HMVEC-d cells (Figure 3B).
Transcription (levels) of PGE2 in d cells associated with herpes simplex virus and infection
5) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.09 Pain Relevance 0
PGE2 levels in MMTV/NDL mammary glands correlated with Cox-2 gene dosage.
Transcription (levels) of PGE2 in mammary glands
6) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.34 Pain Relevance 0

General Comments

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