INT9261

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Context Info
Confidence 0.73
First Reported 1990
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 15
Total Number 30
Disease Relevance 15.58
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
erythrocytes 4
brain 2
blood 1
testis 1
filaments 1
CR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 4 99.62 Very High Very High Very High
Morphine 4 99.08 Very High Very High Very High
Glutamate 1 98.94 Very High Very High Very High
depression 6 98.18 Very High Very High Very High
spinal inflammation 8 93.48 High High
narcan 4 93.04 High High
rheumatoid arthritis 14 92.20 High High
ischemia 36 85.60 High High
Inflammation 11 77.52 Quite High
Opioid 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Thalassemia 208 99.78 Very High Very High Very High
Targeted Disruption 177 99.78 Very High Very High Very High
INFLAMMATION 15 99.44 Very High Very High Very High
Apoptosis 1 99.32 Very High Very High Very High
Rheumatic Diseases 8 98.92 Very High Very High Very High
Brain Injury 3 98.56 Very High Very High Very High
Malaria 588 98.54 Very High Very High Very High
Anxiety Disorder 4 98.42 Very High Very High Very High
Anaemia 124 98.36 Very High Very High Very High
Depression 6 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this system we showed that expression of CR1 rendered red cells more susceptible to P. falciparum invasion.
Gene_expression (expression) of CR1
1) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.52 Pain Relevance 0
Based on our findings, we predicted a correlation between CR1 expression level and the level of P. falciparum invasion, especially in neuraminidase-treated cells.
Gene_expression (expression) of CR1
2) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.21 Pain Relevance 0
Since there is no complete absence of CR1 among humans, to show the effect of complete absence of CR1 on invasion we compared the invasion of wild-type mouse red cells, which do not express CR1, and mouse transgenic red cells expressing human CR1.
Neg (not) Gene_expression (express) of CR1 associated with targeted disruption
3) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.50 Pain Relevance 0
In the mouse, CR1 is expressed mostly on B cells and not on red cells [24].
Neg (not) Gene_expression (expressed) of CR1 in B cells
4) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.44 Pain Relevance 0
The correlation between invasion and CR1 expression level further suggests that the contribution of CR1 to the overall invasion is determined by the number of CR1 molecules present on the red cell.
Gene_expression (expression) of CR1
5) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.42 Pain Relevance 0
Also, the invasion of neuraminidase-treated erythrocytes correlates with the level of CR1 expression.
Gene_expression (expression) of CR1 in erythrocytes
6) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2887475 Disease Relevance 0.60 Pain Relevance 0
In major depression and anxiety: 1) a marked reduction in the number of monocytes that ingested particles and expressed cytoskeletal intermediate filaments and surface structures (CR1 receptors and HLA-DR antigens); 2) a monocytosis that was not able to normalize the count of functioning monocytes; 3) an in vitro correction of the monocyte dysfunction by naloxone; 4) a decrease in NK cell number and activity; and 6) an anergy to candidin and tuberculin and a diminished lectin-induced blastogenesis were observed.
Gene_expression (expressed) of CR1 in NK cell associated with depression, anxiety disorder and narcan
7) Confidence 0.65 Published 1998 Journal J. Physiol. Biochem. Section Abstract Doc Link 10225412 Disease Relevance 0.78 Pain Relevance 0.42
Since there is no complete absence of CR1 among humans, to show the effect of complete absence of CR1 on invasion we compared the invasion of wild-type mouse red cells, which do not express CR1, and mouse transgenic red cells expressing human CR1.
Gene_expression (expressing) of CR1 associated with targeted disruption
8) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.46 Pain Relevance 0
Antibodies to CR1 and Soluble CR1 (sCR1) Block Sialic Acid-independent Invasion
Gene_expression (Antibodies) of CR1
9) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.15 Pain Relevance 0
Since there is no complete absence of CR1 among humans, to show the effect of complete absence of CR1 on invasion we compared the invasion of wild-type mouse red cells, which do not express CR1, and mouse transgenic red cells expressing human CR1.
Neg (absence) Gene_expression (absence) of CR1 associated with targeted disruption
10) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.43 Pain Relevance 0
Antibodies to CR1 and Soluble CR1 (sCR1) Block Sialic Acid-independent Invasion
Gene_expression (Antibodies) of CR1
11) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.15 Pain Relevance 0
For blocking with soluble CR1 (sCR1) (AVANT Immunotherapeutics, Inc., Needham, MA, USA), bovine serum albumin, fetuin, and ?
Gene_expression (soluble) of CR1
12) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.49 Pain Relevance 0
For detection of CR1, a 4% hematocrit cell suspension was incubated with chicken anti-human CR1 Fab at 8 µg/ml for 30 min at RT and washed three times with RPMI 1640.
Gene_expression (detection) of CR1
13) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.73 Pain Relevance 0
METHODS: Using flow cytometric assay of whole human blood, we investigated direct effects of endogenous and synthetic opioid peptides on surface expression of complement receptors CD35 and CD11b/CD18 and Fcã receptor III CD16, and superoxide anion generation of neutrophils.
Gene_expression (expression) of CD35 in neutrophils
14) Confidence 0.59 Published 2003 Journal Br J Anaesth Section Body Doc Link 14504158 Disease Relevance 0.09 Pain Relevance 0
Several recent studies have demonstrated a marked neuroprotective effect of nimesulide on chronic cerebral hypoperfusion [15], kainate-induced excitotoxicity [16], quisqualic acid-induced neurodegeneration [17], diffuse traumatic brain injury [18,19], glutamate-mediated apoptotic damage [20] and induction of the expression of the B subunit of endogenous complement component C1q (C1qB) in transgenic mice with neuronal overexpression of human COX-2 [21].
Gene_expression (expression) of complement component in brain associated with targeted disruption, glutamate, apoptosis and brain injury
15) Confidence 0.58 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC546225 Disease Relevance 1.12 Pain Relevance 0.28
This molecule was previously dismissed when the invasion of erythrocytes expressing very low levels of CR1 (Helgeson phenotype) by sialic acid-independent strain Dd2SNM (similar to Dd2NM used here) was not completely abolished after neuraminidase treatment [27].
Gene_expression (expressing) of CR1 in erythrocytes associated with sprains and strains
16) Confidence 0.56 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.61 Pain Relevance 0
Antibodies to CR1 and Soluble CR1 (sCR1) Block Sialic Acid-independent Invasion
Gene_expression (Antibodies) of sCR1
17) Confidence 0.55 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.15 Pain Relevance 0
For blocking with soluble CR1 (sCR1) (AVANT Immunotherapeutics, Inc., Needham, MA, USA), bovine serum albumin, fetuin, and ?
Gene_expression (soluble) of sCR1
18) Confidence 0.55 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.50 Pain Relevance 0
Although sCR1 is present in serum, its levels are much lower than those required for inhibition of merozoite invasion [28].
Gene_expression (present) of sCR1
19) Confidence 0.49 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.49 Pain Relevance 0
An investigation was conducted to measure the levels of erythrocyte complement receptor type 1 (CR1) in patients with various rheumatic diseases other than systemic lupus erythematosus, and to evaluate the clinical significance of this receptor in patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA).
Gene_expression (levels) of CR1 in erythrocyte associated with spinal inflammation, rheumatoid arthritis, systemic lupus erythematosus and rheumatic diseases
20) Confidence 0.32 Published 1990 Journal Rheumatol. Int. Section Abstract Doc Link 2349436 Disease Relevance 1.11 Pain Relevance 0.44

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