INT92618

Context Info Confidence 0.48 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 3.54 Pain Relevance 0.75

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)

Anatomy Link Frequency lobe 1 body 1 LCT (Homo sapiens)

Pain Link Frequency Relevance Heat Lamotrigine 4 98.60 nud 3 89.64 abdominal pain 3 88.80 Pain 2 85.60 Arthritis 1 74.60 Perioperative pain 6 70.40 Migraine 4 50.00 aspirin 4 46.72 Dopamine 10 5.00 cytokine 5 5.00

Disease Link Frequency Relevance Heat Malabsorption Syndromes 7 98.12 Giardiasis 7 96.44 Systemic Lupus Erythematosus 51 93.72 Lactose Intolerance 2 92.48 Dyspepsia 3 89.64 Diarrhoea 5 89.24 Abdominal Pain 3 88.80 Metabolic Disorder 1 85.72 Pain 2 85.60 Flatulence 4 84.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Molecular studies of lactose intolerance led to the identification of specific variations in a cis-regulatory element of the LCT gene resulting in lactase persistence (LP) which is an autosomal dominant condition (MIM 223100).

Positive_regulation (resulting) of lactase associated with malabsorption syndromes

1) Confidence 0.48 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.45 Pain Relevance 0.13

In some adults, however, high levels of lactase activity persist into adulthood.

Positive_regulation (levels) of lactase

2) Confidence 0.47 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.72 Pain Relevance 0.09

The biochemistry profile, adverse events, and physical examination (except body weight where there was a statistically significant increase in the Bic/Lac group) results did not differ significantly between the two groups.

Positive_regulation (increase) of Lac in body

3) Confidence 0.45 Published 2000 Journal Perit Dial Int Section Body Doc Link 11117242 Disease Relevance 0.05 Pain Relevance 0

RESULTS: Linear correlation between increase in both WSS Lac/Cr value in left temporal lobe and WSS ml/Cr value in right frontal lobe and a number of migraine attacks per year in migraine patients was observed.

Positive_regulation (increase) of Lac in lobe

4) Confidence 0.45 Published 2010 Journal Prz. Lek. Section Body Doc Link 20687355 Disease Relevance 0.09 Pain Relevance 0

The DNA region of the LCT -13910C>T lactase persistence-non persistence variant functioned in vitro as a cis regulatory element capable of enhancing differential transcriptional activation of the lactase promoter that is consistent with a causative role in the mechanism of lactase persistence/non-persistence phenotypes in humans [6].

Positive_regulation (activation) of lactase

5) Confidence 0.42 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.29 Pain Relevance 0.11

Estimation of lactase, sucrase, maltase and trehalase was done in biopsies.

Positive_regulation (Estimation) of lactase

6) Confidence 0.38 Published 2000 Journal Trop Gastroenterol Section Abstract Doc Link 11194577 Disease Relevance 0.74 Pain Relevance 0.13

In the study of Polle et al. total costs for surgery were significantly higher in the LAC group (p < 0.001), due to the higher costs of disposable material (trocars) and the longer operating time required for LAC surgery.

Positive_regulation (required) of LAC

7) Confidence 0.19 Published 2008 Journal Surg Endosc Section Body Doc Link PMC2471396 Disease Relevance 0.31 Pain Relevance 0.13

With the wide implementation of LAC, the technical difficulties and limitations of the LAC procedures have become clear.

Positive_regulation (implementation) of LAC

8) Confidence 0.19 Published 2008 Journal Surg Endosc Section Body Doc Link PMC2471396 Disease Relevance 0 Pain Relevance 0

Similarly, while the induction of LAC by a combination of valproate and lamotrigine has been described [2], that patient's GPL was at the cutoff level considered to be positive and the MPL was normal.

Positive_regulation (induction) of LAC associated with lamotrigine

9) Confidence 0.03 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 0.90 Pain Relevance 0.17

General Comments

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