INT92622

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.16
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
nerve 2
neurons 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 136 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
depression 33 98.94 Very High Very High Very High
Neurotransmitter 8 98.48 Very High Very High Very High
antidepressant 21 97.94 Very High Very High Very High
Pain 35 93.68 High High
Sciatic nerve 7 91.84 High High
Hippocampus 62 89.12 High High
lidocaine 6 88.88 High High
Spinal cord 41 73.92 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 100.00 Very High Very High Very High
Stress 168 99.96 Very High Very High Very High
Depression 35 98.94 Very High Very High Very High
Pain 54 93.68 High High
Neurodegenerative Disease 8 93.28 High High
Targeted Disruption 1 85.92 High High
Nociception 7 82.48 Quite High
Status Epilepticus 1 76.80 Quite High
Neuropathic Pain 29 55.20 Quite High
Hypersensitivity 18 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the levels of acetylated histone H3, but not H4, on each promoter of the BDNF gene correlated with the mRNA expression of each exon, except exon VI, in response to SIS.
Neg (except) Regulation (correlated) of Positive_regulation (levels) of BDNF associated with stress
1) Confidence 0.39 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.61 Pain Relevance 0.19
Involvement of afferent nerve transmission in the incision-mediated BDNF upregulation
Regulation (Involvement) of Positive_regulation (upregulation) of BDNF in nerve associated with bdmf
2) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.14 Pain Relevance 0.94
Interestingly, investigators have shown that the efficacy of antidepressants in ameliorating behavioral symptoms of depression, in depressed patients and animal models of stress, depends on their ability to increase BDNF levels [6,25,29].
Regulation (depends) of Positive_regulation (increase) of BDNF associated with stress, antidepressant and depression
3) Confidence 0.14 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 1.06 Pain Relevance 0.35
In order to determine whether neurotransmitter expression is modulated in response to the elevation of neurotrophins, the changes in c-fos, neuropeptide and glutamic acid decarboxylase (GAD) mRNAs expression was evaluated after BDNF or NT-3 was applied to cultured spinal neurons.
Regulation (changes) of Positive_regulation (evaluated) of BDNF in neurons associated with neurotransmitter, generalized anxiety disorder and neuropeptide
4) Confidence 0.07 Published 2000 Journal Neuroreport Section Abstract Doc Link 11117506 Disease Relevance 0.35 Pain Relevance 0.33

General Comments

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