INT92632

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 48
Total Number 55
Disease Relevance 19.93
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2) biological_process (Vsig2)
Anatomy Link Frequency
RBA 3
brain 2
body 2
liver 1
atrium 1
Vsig2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 21 100.00 Very High Very High Very High
Osteoarthritis 259 98.32 Very High Very High Very High
tetrodotoxin 37 98.20 Very High Very High Very High
Catecholamine 40 98.08 Very High Very High Very High
depression 80 95.76 Very High Very High Very High
cytokine 28 92.88 High High
Inflammation 161 92.32 High High
sodium channel 684 91.44 High High
antagonist 34 88.08 High High
Arthritis 9 83.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 181 99.98 Very High Very High Very High
Poisoning 7224 99.92 Very High Very High Very High
Toxicity 1059 99.80 Very High Very High Very High
Osteophyte 130 99.72 Very High Very High Very High
Body Weight 136 99.66 Very High Very High Very High
Hypothermia 131 99.56 Very High Very High Very High
Ciguatera Poisoning 1817 98.36 Very High Very High Very High
Knee Osteoarthritis 6 98.32 Very High Very High Very High
Sprains And Strains 396 96.28 Very High Very High Very High
Depression 80 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, RBA toxicity could be expressed as pg P-CTX-3C eqv/cell for Gambierdiscus samples, and as ng C-CTX-1 eqv g?
Gene_expression (expressed) of CTX-1 in RBA associated with toxicity
1) Confidence 0.50 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.10 Pain Relevance 0.03
The 51-hydroxyCTX and CTX (CTX-1B) were also synthesized [142–144].
Gene_expression (synthesized) of CTX
2) Confidence 0.50 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.16 Pain Relevance 0
The synthesis of CTX to resolve the lack of availability of CTXs pure material appears as an ambitious challenge reflected by its large (3 nm long) and complex ladder-like structure [139].
Gene_expression (synthesis) of CTX
3) Confidence 0.50 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.14 Pain Relevance 0
Efforts directed at the synthesis of CTX congeners are necessary and may accelerate the preparation of anti-CTX antibodies.
Gene_expression (synthesis) of CTX
4) Confidence 0.50 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.16 Pain Relevance 0
The 51-hydroxyCTX and CTX (CTX-1B) were also synthesized [142–144].
Gene_expression (synthesized) of CTX-1B
5) Confidence 0.50 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.16 Pain Relevance 0
Studying toxin production in cultures also helps to describe the kinetics of CTX production under specific, controlled laboratory conditions [77,122,123] or according to the physiological growth stage of Gambierdiscus spp. cells [69].
Gene_expression (production) of CTX
6) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.23 Pain Relevance 0
This review aims to describe the methodologies available for CTX detection, including those based on the toxicological, biochemical, chemical, and pharmaceutical properties of CTXs.
Gene_expression (detection) of CTX
7) Confidence 0.44 Published 2010 Journal Marine Drugs Section Abstract Doc Link PMC2901828 Disease Relevance 0.71 Pain Relevance 0
However, the ability to produce CTX precursors seems to be genetically determined in Gambierdiscus, and limited to only certain strains of Gambierdiscus spp. [69,74].
Gene_expression (produce) of CTX associated with sprains and strains
8) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.15 Pain Relevance 0
The abundance and distribution of Gambierdiscus spp., as well as CTX production by these microalgae in natural populations, are routinely monitored by some laboratories in ciguatera endemic areas.
Gene_expression (production) of CTX associated with ciguatera poisoning
9) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.37 Pain Relevance 0
This is particularly apparent when we take into consideration that travelling to tropical areas is not anecdotic and that the distribution of ciguateric fish and CTX-producing microalgae might be expanding in European waters.
Gene_expression (producing) of CTX
10) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.78 Pain Relevance 0
No data are currently available regarding CTX production.
Gene_expression (production) of CTX
11) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.28 Pain Relevance 0
The occurrence of toxic (CTX producing) Gambierdiscus spp. blooms may be used as a bio-indicator of local ciguatera risk in a specific area [33,34].
Gene_expression (producing) of CTX associated with ciguatera poisoning
12) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.34 Pain Relevance 0
Determination of CTX production by Gambierdiscus spp. cultures, in parallel with taxonomic studies of the genus Gambierdiscus, is crucial for associating toxin production with a particular Gambierdiscus species [67,68].
Gene_expression (production) of CTX
13) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.32 Pain Relevance 0
Additionally, the recent detection of the CTX-producing tropical genus Gambierdiscus in the eastern Atlantic Ocean of the northern hemisphere and in the Mediterranean Sea, as well as the confirmation of CFP in the Canary Islands and possibly in Madeira, constitute other reasons to study the onset of CFP in Europe [1].
Gene_expression (producing) of CTX associated with poisoning
14) Confidence 0.44 Published 2010 Journal Marine Drugs Section Abstract Doc Link PMC2901828 Disease Relevance 0.93 Pain Relevance 0
Production of gambiertoxins (ciguatoxin precursors e.g., CTX-4B) by in vitro culturing of Gambierdiscus spp. was proposed as an alternative supply of CTXs for reference material production [16].
Gene_expression (Production) of CTX-4B
15) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.34 Pain Relevance 0
This is important as the IC50 for Caribbean CTX-1 is as low as 0.29 pg mL?
Gene_expression (low) of CTX-1
16) Confidence 0.44 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.39 Pain Relevance 0
CTX was detected at a concentration of 50 microg/ml.
Gene_expression (detected) of CTX
17) Confidence 0.43 Published 2000 Journal Toxicology Section Abstract Doc Link 11118665 Disease Relevance 0.23 Pain Relevance 0.68
Historically, Hokama's group in Hawaii [198] was the first to report the production of sheep polyclonal Abs (PAbs) to a partially purified CTX (CTX-1B).
Gene_expression (production) of CTX-1B
18) Confidence 0.39 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.29 Pain Relevance 0
Secondly, risk management should propose actions aiming at the reduction of risk, mainly through the establishment of monitoring programs for CTX producing species and toxins in food.
Gene_expression (producing) of CTX
19) Confidence 0.39 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.91 Pain Relevance 0
Taking into account the limit of detection of 0.5–1 ng on-column, such toxic levels might be achieved from a 50–100 g sample in the case that only P-CTX-1 is present.
Gene_expression (present) of CTX-1
20) Confidence 0.39 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.31 Pain Relevance 0

General Comments

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