INT92648

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Context Info
Confidence 0.20
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.55
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)
Anatomy Link Frequency
macrophage 1
lung 1
IL12B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 139 100.00 Very High Very High Very High
antagonist 3 99.90 Very High Very High Very High
dexamethasone 43 99.70 Very High Very High Very High
chemokine 18 99.08 Very High Very High Very High
Inflammatory response 14 97.36 Very High Very High Very High
Inflammation 93 93.88 High High
fibrosis 2 76.32 Quite High
cINOD 3 75.00 Quite High
agonist 7 55.80 Quite High
Inflammatory mediators 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 7 99.28 Very High Very High Very High
Necrosis 5 99.04 Very High Very High Very High
Severe Acute Respiratory Syndrome 50 98.60 Very High Very High Very High
Influenza Virus Infection 23 97.28 Very High Very High Very High
INFLAMMATION 117 96.96 Very High Very High Very High
Infection 40 95.60 Very High Very High Very High
Critical Illness 37 94.60 High High
Lower Respiratory Tract Infection 4 91.60 High High
Viral Infection 17 89.72 High High
Fibrosis 1 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of IL12B in lung associated with chemokine and cytokine
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.55 Pain Relevance 0.14
2) was reduced in the Iota-Carrageenan group upon treatment, while IL-1 receptor antagonist and IL-12p40 were increased.
Positive_regulation (increased) of IL-12p40 associated with antagonist
2) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.53 Pain Relevance 0.22
and IL-12-p40 were upregulated, whereas genes upregulated in the SARS patients (LTF, Lipocalin, S100P, FGR3A and TLR2), were not upregulated in the influenza patients.
Positive_regulation (upregulated) of IL-12 associated with influenza virus infection and severe acute respiratory syndrome
3) Confidence 0.08 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.01 Pain Relevance 0.16
and IL12 were not elevated in sera from AFP, FP and controls.
Neg (not) Positive_regulation (elevated) of IL12
4) Confidence 0.05 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.26 Pain Relevance 0.57
A concomitant decrease of mRNA accumulation was also observed for interferon-gamma (nine of 11 patients), interleukin-6 (nine of 11), and interleukin-12 p40 (six of eight).
Positive_regulation (accumulation) of interleukin-12 p40
5) Confidence 0.04 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121122 Disease Relevance 0.98 Pain Relevance 0.36
-induced macrophage activation through participation of cytokines, mainly IL12 and also IL2 and tumor necrosis factor, and the intracellular parasite killing by activated macrophages [8].
Positive_regulation (induced) of IL12 in macrophage associated with necrosis, cancer and cytokine
6) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.99 Pain Relevance 0.13
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
Positive_regulation (induced) of IL-12p40 associated with dexamethasone
7) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.22 Pain Relevance 0.61

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