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Context Info
Confidence 0.03
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)
IL12B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 98.20 Very High Very High Very High
Inflammation 10 97.52 Very High Very High Very High
chemokine 3 93.20 High High
backache 2 84.88 Quite High
headache 2 82.04 Quite High
cINOD 1 75.00 Quite High
Inflammatory response 1 42.72 Quite Low
imagery 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 99.76 Very High Very High Very High
Necrosis 4 99.52 Very High Very High Very High
INFLAMMATION 12 97.52 Very High Very High Very High
Vasculitis 5 89.20 High High
Dizziness 2 85.48 High High
Mycobacterium Infection 4 85.00 Quite High
Low Back Pain 2 84.88 Quite High
Fever 4 84.28 Quite High
Myalgia 2 82.56 Quite High
Headache 2 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed expression of interferon-gamma, interleukin-6, interleukin-10, interleukin-12 p40, and tumor necrosis factor-alpha in all patients tested at the onset of reactional episodes, but interleukin-4 mRNA was rarely detected in the lesions (n = 4).
Negative_regulation (showed) of Gene_expression (expression) of interleukin-12 p40 associated with necrosis and cancer
1) Confidence 0.03 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121122 Disease Relevance 0.85 Pain Relevance 0.24
Peak levels of IL-12p70 were detected at 6 hours and then slowly declined to 48 hours.
Negative_regulation (declined) of Gene_expression (levels) of IL-12p70
2) Confidence 0.02 Published 2007 Journal J Transl Med Section Body Doc Link PMC2248163 Disease Relevance 1.04 Pain Relevance 0.30
Thalidomide inhibits TNF-alpha by amplifying the degradation of messenger RNA (mRNA), and decreases the production of interleukin-12, which is involved in immunity responses, the stimulation of inflammation, and suppression of certain cytokines [29-31].
Negative_regulation (decreases) of Gene_expression (production) of interleukin-12 associated with inflammation and cytokine
3) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0.35 Pain Relevance 0.31

General Comments

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