INT92653

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 17.28
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)
Anatomy Link Frequency
macrophages 2
T-cell 2
blood 1
B lymphocytes 1
lung 1
IL12B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 312 100.00 Very High Very High Very High
Inflammation 168 99.90 Very High Very High Very High
agonist 11 99.66 Very High Very High Very High
chemokine 77 98.90 Very High Very High Very High
tolerance 1 91.16 High High
backache 2 84.88 Quite High
Arthritis 171 84.68 Quite High
headache 9 82.04 Quite High
spinal inflammation 82 79.16 Quite High
rheumatoid arthritis 84 79.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 188 99.90 Very High Very High Very High
Cancer 283 99.76 Very High Very High Very High
Necrosis 13 99.52 Very High Very High Very High
Infection 517 98.36 Very High Very High Very High
Dengue 230 98.24 Very High Very High Very High
Cold Sores 36 97.04 Very High Very High Very High
Reprotox - General 1 8 96.60 Very High Very High Very High
Syndrome 59 96.36 Very High Very High Very High
Critical Illness 37 94.24 High High
Glioblastoma 5 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are induced by murine macrophages in response to both TLR-2 and TLR-4 agonists, however, iNOS, IL-12p40, IP-10 and MCP-5 are produced primarily in response to TLR-4 agonists [130,131].
Gene_expression (produced) of IL-12p40 in macrophages associated with agonist
1) Confidence 0.75 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.26 Pain Relevance 0.59
Activation of tissue macrophages and DCs, for instance, results in production of IL12 (comprising IL12a/IL12b heterodimers) and subsequent INF?
Gene_expression (production) of IL12b in macrophages
2) Confidence 0.75 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.91 Pain Relevance 0.16
The TH1 response was characterized by high levels of IL-12p40 and IFN?.
Gene_expression (levels) of IL-12p40
3) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.60 Pain Relevance 0.20
The concentration of TH1 IL-12p40 was higher in the blood of Qro-infected mice than in Ninoa-infected mice.
Gene_expression (concentration) of IL-12p40 in blood
4) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.46 Pain Relevance 0.03
0.82 (95% CI:0.74–0.91)), IL12B (rs10045431, P?
Gene_expression (rs10045431) of IL12B
5) Confidence 0.64 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.51 Pain Relevance 0.16
0.65 (95% CI:0.54–0.79)), and further associations were detected for IL12B (rs10045431, P?
Gene_expression (detected) of IL12B
6) Confidence 0.64 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 1.14 Pain Relevance 0.53
Using real-time PCR, the relative gene expression of IL-10, IL-12p35, IL-12p40, IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was quantified in T cells.


Gene_expression (expression) of IL-12p40 in T cells
7) Confidence 0.58 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.72 Pain Relevance 0.04
The expression of IL-12p40, IL-23p19, CCR7 and iNOS from most of the samples were below the detection limit (data not shown).
Gene_expression (expression) of IL-12p40
8) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.38 Pain Relevance 0
Additionally, the peak of IL-12p40 gene expression was observed very early at 4 hours post-infection.
Gene_expression (expression) of IL-12p40 associated with infection
9) Confidence 0.58 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 0.35 Pain Relevance 0
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Gene_expression (levels) of IL12B in lung associated with chemokine and cytokine
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.55 Pain Relevance 0.14
Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFN?
Gene_expression (response) of IL-12p40 associated with inflammation
11) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2852613 Disease Relevance 0.92 Pain Relevance 0.05
Some that are currently in development and at the trial stages are agents targeting IL-1, cytokines from the TNF superfamily, IL-15, IL-17, B lymphocytes, IL-12/IL-23, SyK kinase, JAK3 kinase, and inhibitors of osteoclastogenesis.40–51

Chemistry and mechanism of action

Gene_expression (/) of IL-12 in B lymphocytes associated with cytokine
12) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.39 Pain Relevance 0.44
Levels of IL2, IL4, IL10 and IL12 were not significantly different between cases and controls.
Gene_expression (Levels) of IL12
13) Confidence 0.07 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 0.29 Pain Relevance 0.23
The median levels of IL2, IL4, IL5, IL12, and IFN?
Gene_expression (levels) of IL12
14) Confidence 0.07 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 0.28 Pain Relevance 0.22
The IL12 receptor ?
Gene_expression (receptor) of IL12
15) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.56 Pain Relevance 0.12
Results showed expression of interferon-gamma, interleukin-6, interleukin-10, interleukin-12 p40, and tumor necrosis factor-alpha in all patients tested at the onset of reactional episodes, but interleukin-4 mRNA was rarely detected in the lesions (n = 4).
Gene_expression (expression) of interleukin-12 p40 associated with necrosis and cancer
16) Confidence 0.05 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121122 Disease Relevance 0.84 Pain Relevance 0.24
Peak levels of IL-12p70 were detected at 6 hours and then slowly declined to 48 hours.
Gene_expression (levels) of IL-12p70
17) Confidence 0.03 Published 2007 Journal J Transl Med Section Body Doc Link PMC2248163 Disease Relevance 0.93 Pain Relevance 0.30
A TH1-based immune response was seen in rat prostate cancer models undergoing HSV-Tk/GCV therapy [15], and a clinical study also showed elevated numbers of peripheral T and B cells, enhanced T-cell activation, and elevated serum levels of interleukin 12 during intracranial GCV treatment

[16].

Gene_expression (levels) of interleukin 12 in T-cell associated with cold sores and reprotox - general 1
18) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.05 Pain Relevance 0
Moreover, these cells showed low or no expression of the Th1- or Th2-related cytokines IL-2, IFN-gamma, IL-13, IL-12B, IL-4, and IL-5 and the chemoattractant receptor CRTH2.
Neg (no) Gene_expression (expression) of IL-12B associated with cytokine
19) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.07 Pain Relevance 0.09
Thalidomide inhibits TNF-alpha by amplifying the degradation of messenger RNA (mRNA), and decreases the production of interleukin-12, which is involved in immunity responses, the stimulation of inflammation, and suppression of certain cytokines [29-31].
Gene_expression (production) of interleukin-12 associated with inflammation and cytokine
20) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0.35 Pain Relevance 0.31

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