INT92654

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.33
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
blood 1
skin 1
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 128 100.00 Very High Very High Very High
Inflammatory response 60 100.00 Very High Very High Very High
cytokine 36 99.96 Very High Very High Very High
Inflammatory stimuli 35 99.16 Very High Very High Very High
headache 1 51.36 Quite High
corticosteroid 56 50.00 Quite Low
Pain 4 50.00 Quite Low
ischemia 1 36.56 Quite Low
depression 1 28.64 Quite Low
neuralgia 4 10.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 199 100.00 Very High Very High Very High
Cancer 5 99.52 Very High Very High Very High
Necrosis 5 99.28 Very High Very High Very High
Acrodermatitis 5 99.10 Very High Very High Very High
Infection 3 98.80 Very High Very High Very High
Erythema 6 98.22 Very High Very High Very High
Pulmonary Disease 13 95.80 Very High Very High Very High
Pain 2 92.08 High High
Pneumonia 2 91.64 High High
Bronchitis 1 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism behind the augmentation of PM effect is unclear, but may be explained by changes in transcription of pro-inflammatory genes secondary to the acute infection.
Transcription (transcription) of pro-inflammatory associated with inflammation and infection
1) Confidence 0.01 Published 2007 Journal Environ Health Section Body Doc Link PMC1800891 Disease Relevance 0.99 Pain Relevance 0.19
Second, in (1) the variable DR* is assumed to be the convoluted signal that propagates the LPS signaling initiating the transcriptional synthesis of both the pro-inflammatory response (P) and the mRNA of TLR4 (mRNA,R).
Transcription (synthesis) of pro-inflammatory associated with inflammatory response and inflammatory stimuli
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.77 Pain Relevance 0.44
METHODS: In this prospective study, we analyzed blood mRNA and protein levels of the pro-inflammatory cytokines interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF) and the anti-inflammatory cytokines IL-4 and IL-10 in 32 patients with painful neuropathy, 20 patients with painless neuropathy, and 38 healthy control subjects, using quantitative real-time PCR and ELISA.
Spec (analyzed) Transcription (levels) of pro-inflammatory in blood
3) Confidence 0.00 Published 2007 Journal Neurology Section Body Doc Link 17606879 Disease Relevance 0.09 Pain Relevance 0
In an effort to understand pathogenic factors that lead to different outcomes in dermatoborrelioses, skin biopsy samples from 42 patients with erythema migrans and 27 patients with acrodermatitis chronica atrophicans were analyzed for mRNA expression of five pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1 beta, interleukin-6, interferon-gamma, and interleukin-2) and two anti-inflammatory cytokines (interleukin-4 and interleukin-10) by in situ hybridization with cytokine-specific riboprobes.
Transcription (expression) of pro-inflammatory in skin associated with necrosis, erythema, inflammation, cancer, acrodermatitis and cytokine
4) Confidence 0.00 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121150 Disease Relevance 1.48 Pain Relevance 0.49

General Comments

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