INT92662

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.44
Pain Relevance 6.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
nerve 6
blood 2
neurons 2
spinal cord 2
brain 2
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 60 100.00 Very High Very High Very High
Sciatic nerve 9 100.00 Very High Very High Very High
bDMF 8 100.00 Very High Very High Very High
neurotrophin 3 6 100.00 Very High Very High Very High
Spinal cord 2 99.68 Very High Very High Very High
dorsal root ganglion 3 99.44 Very High Very High Very High
opiate 5 99.24 Very High Very High Very High
addiction 3 98.96 Very High Very High Very High
intrathecal 7 98.90 Very High Very High Very High
Locus ceruleus 7 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
Diabetes Mellitus 25 99.82 Very High Very High Very High
Opiate Addiction 3 99.24 Very High Very High Very High
Ganglion Cysts 3 98.96 Very High Very High Very High
Death 4 96.72 Very High Very High Very High
Frailty 3 95.64 Very High Very High Very High
Parkinson's Disease 1 94.56 High High
Hyperalgesia 3 94.44 High High
Hydrocephalus 28 93.84 High High
Neuropathic Pain 14 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Negative_regulation (prevention) of Gene_expression (expression) of neurotrophin 3 in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
1) Confidence 0.57 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.17 Pain Relevance 0.87
We hypothesize that deficits in neurotrophic factor support, specifically linked to diabetes-induced lowered expression of insulin and neurotrophin-3, triggers alterations of sensory neurone phenotype that are critical for the development of abnormal Ca(2+) homeostasis and associated mitochondrial dysfunction.
Negative_regulation (lowered) of Gene_expression (expression) of neurotrophin-3 associated with parkinson's disease and diabetes mellitus
2) Confidence 0.41 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18191198 Disease Relevance 1.17 Pain Relevance 0.05
The present study was designed to evaluate the expression of BDNF and NT-3 in the context of opiate dependence and withdrawal in PGi.
Negative_regulation (evaluate) of Gene_expression (expression) of NT-3 associated with addiction, opiate, withdrawal and bdmf
3) Confidence 0.41 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.26 Pain Relevance 1.66
Since NGF and NT-3 CSF concentrations were also related to overall CSF protein levels in hydrocephalic children, some of the NGF and NT-3 molecules detected in CSF may actually be derived from neurotrophins circulating in the blood.
Negative_regulation (derived) of Gene_expression (detected) of NT-3 in blood associated with nerve growth factor
4) Confidence 0.39 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.72
The oligonucleotides used in this study were phosphorothioate modified and control experiments, using an ELISA, confirm that intrathecal administration of the antisense induces a significant decrease in NT-3 levels in the spinal cord.
Negative_regulation (decrease) of Gene_expression (levels) of NT-3 in spinal cord associated with spinal cord and intrathecal
5) Confidence 0.37 Published 2000 Journal Brain Res. Section Abstract Doc Link 11121532 Disease Relevance 0.71 Pain Relevance 0.92
The observed initial increase and subsequent decline in expression of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor correlate with the apparent spatio-temporal decline in the regenerative capacity of motor axons, indicating that the distal nerve is losing its capacity to support regenerating motor axons following prolonged denervation.
Negative_regulation (decline) of Gene_expression (expression) of neurotrophic factor in brain
6) Confidence 0.37 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19646436 Disease Relevance 0 Pain Relevance 0.05
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Negative_regulation (prevention) of Gene_expression (expression) of nerve growth factor in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
7) Confidence 0.25 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.06 Pain Relevance 0.86
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Negative_regulation (prevention) of Gene_expression (expression) of nerve growth factor in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
8) Confidence 0.25 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.11 Pain Relevance 0.86
High GC levels render neurons more susceptible to neurological insults via disruption of anti-apoptotic factor [40] and neurotrophic factor expression [15,41,42].
Negative_regulation (disruption) of Gene_expression (expression) of neurotrophic factor in neurons associated with apoptosis
9) Confidence 0.05 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 1.35 Pain Relevance 0.22

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