INT92669

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 5
Speculated 9
Reported most in Body
Documents 309
Total Number 319
Disease Relevance 178.26
Pain Relevance 116.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 52
hippocampus 36
neurons 20
cortex 8
neuronal 8
Bdnf (Mus musculus)
Bdnf - V66M (2)
Pain Link Frequency Relevance Heat
depression 7920 100.00 Very High Very High Very High
Hippocampus 4309 100.00 Very High Very High Very High
bDMF 1791 100.00 Very High Very High Very High
amygdala 746 100.00 Very High Very High Very High
Nerve growth factor 632 100.00 Very High Very High Very High
Neuropeptide 158 100.00 Very High Very High Very High
chemokine 76 100.00 Very High Very High Very High
Cholecystokinin 52 100.00 Very High Very High Very High
Pain 417 99.98 Very High Very High Very High
agonist 251 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 10588 100.00 Very High Very High Very High
Repression 219 100.00 Very High Very High Very High
Targeted Disruption 1481 99.98 Very High Very High Very High
Pain 498 99.98 Very High Very High Very High
Hyperalgesia 130 99.96 Very High Very High Very High
Urological Neuroanatomy 1490 99.90 Very High Very High Very High
Suicidal Behaviour 10600 99.84 Very High Very High Very High
Neurodegenerative Disease 827 99.82 Very High Very High Very High
Stress 2793 99.80 Very High Very High Very High
Injury 920 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF is a small dimeric protein and is a member of the neurotrophin family.6 BDNF is widely expressed in the adult mammalian brain, the highest levels being found in the hippocampus, followed by those in the cerebral cortex.7 Further, BDNF plays a key role in the regulation of neuronal survival, differentiation, growth, and apoptosis by binding to two types of receptors; namely, the tyrosine kinase B (trkB) receptor and the p75 neurotrophin receptor (p75NTR).8,9 Moreover, BDNF is involved in the regulation of synaptic synthesis and the release of neurotransmitters.10
Gene_expression (expressed) of BDNF in cerebral cortex associated with neurotransmitter, hippocampus, apoptosis and cerebral cortex
1) Confidence 0.78 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.90 Pain Relevance 0.58
This hypothesis is based on the evidence that stress can decrease the expression of BDNF and lead to the atrophy of the same populations of stress-vulnerable hippocampal neurons, while electroconvulsive therapy (ECT) and antidepressants increase BDNF expression and may reverse or block the atrophy and cell loss resulting from stress and depression.5 In the past decade, this novel hypothesis has greatly changed the landscape for human and animal research on MDD.
Gene_expression (expression) of BDNF in neurons associated with stress, antidepressant, depression and frailty
2) Confidence 0.78 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 1.01 Pain Relevance 0.73
For example, animal studies found that transgenic overexpression of BDNF has a facilitatory effect on anxiety-like behaviors32 and learning and memory impairments.40 A study by Zou et al.24 demonstrated that insomnia and decreased sexual desire, which are side effects of fluoxetine, may have been associated with the BDNF Val66Met polymorphism, and Met allele carriers showed a lower incidence of these adverse effects.
Gene_expression (overexpression) of BDNF associated with targeted disruption, hypoactive sexual desire disorder, anxiety disorder, sleep disorders and fluoxetine
3) Confidence 0.78 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.81 Pain Relevance 0.34
This polymorphism is located 229 bp upstream from the transcription starting site of exon 1 and is not considered to have an effect on the expression of the BDNF gene.
Gene_expression (expression) of BDNF
4) Confidence 0.78 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.40 Pain Relevance 0.37
Specifically, we show that early-life fluoxetine exposure resulted in the long-term upregulation of BDNF expression in adult mice.
Gene_expression (expression) of BDNF associated with fluoxetine
5) Confidence 0.78 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18973993 Disease Relevance 0.42 Pain Relevance 0.89
We examined the long-term effects of a transient early postnatal fluoxetine treatment on depression- and anxiety-related behaviours as well as gene expression of BDNF and its receptor TrkB in C57BL/6J mice.
Gene_expression (expression) of BDNF associated with depression, anxiety disorder and fluoxetine
6) Confidence 0.78 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18973993 Disease Relevance 0.52 Pain Relevance 0.75
Our in situ hybridization revealed that BDNF mRNA was expressed in Schwann cells in the distal segment of lesioned nerve and in the denervated muscle fibres.
Gene_expression (expressed) of BDNF mRNA in muscle
7) Confidence 0.78 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11122329 Disease Relevance 0.22 Pain Relevance 0.07
Expression analyses at perinatal times indicate that BDNF is predominantly produced within sensory ganglia and is more abundant than skin-derived NGF or GDNF.
Gene_expression (produced) of BDNF in ganglia
8) Confidence 0.78 Published 2010 Journal Dev. Biol. Section Abstract Doc Link 20067784 Disease Relevance 0.44 Pain Relevance 0.48
Treatment with piperine (6.25-25 microM) for 72 h reversed the CORT-induced reduction of BDNF mRNA expression in cultured hippocampal neurons.
Gene_expression (expression) of BDNF mRNA in neurons
9) Confidence 0.78 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289085 Disease Relevance 0.33 Pain Relevance 0.28
The synthesis of BDNF is increased in RGCs immediately after intravitreal injection of NMDA in rats [51].
Gene_expression (synthesis) of BDNF
10) Confidence 0.77 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.21 Pain Relevance 0.04
In the present study, therefore, the BDNF expression we detected may be derived from GFAP-positive astroglial cells and/or from retinal ganglion neurons.
Gene_expression (expression) of BDNF in neurons associated with ganglion cysts
11) Confidence 0.77 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.34 Pain Relevance 0.03
In this experiment, we could not clarify the detailed role of BDNF expressed in the SC after NMDA injection.
Neg (not) Gene_expression (expressed) of BDNF
12) Confidence 0.77 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.36 Pain Relevance 0.03
Our study shows that developmental exposure to low levels of MeHg predisposes mice to depression and induces epigenetic suppression of BDNF gene expression in the hippocampus.
Gene_expression (expression) of BDNF gene in hippocampus associated with depression and hippocampus
13) Confidence 0.77 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18485098 Disease Relevance 0.24 Pain Relevance 0.44
Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury.
Gene_expression (expression) of BDNF gene associated with depression
14) Confidence 0.77 Published 2008 Journal J. Neurochem. Section Title Doc Link 18485098 Disease Relevance 0.27 Pain Relevance 0.32
Behavioral alterations are associated with a decrease in brain-derived neurotrophic factor (BDNF) mRNA in the hippocampal dentate gyrus and fluoxetine treatment restores BDNF mRNA expression.
Gene_expression (expression) of BDNF mRNA in dentate gyrus associated with fluoxetine
15) Confidence 0.77 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18485098 Disease Relevance 0.23 Pain Relevance 0.46
Altogether, these studies suggest that although BDNF expression is repressed or induced by stress or antidepressants by different mechanisms, epigenetic regulation of the BDNF gene plays an important role in depression and in the mechanisms of action of antidepressants.


Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
16) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.10 Pain Relevance 0.32
Based on these studies, the neurotrophin hypothesis of depression was proposed, which suggests that stress and depression is associated with decreased expression of BDNF and that antidepressants alleviate depressive behavior by increasing its level.15,16 This is quite relevant given that BDNF is involved in synaptic plasticity and, as earlier mentioned, compromised synaptic and structural plasticity have been shown to be associated with depression.
Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
17) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.06 Pain Relevance 0.32
Although the previous studies did not find sex-specific changes in BDNF expression in the hippocampus or cortical areasb,181,182 whether sex-specific effect in BDNF expression is specific to the midbrain area needs further studies.
Gene_expression (expression) of BDNF in hippocampus associated with midbrain and hippocampus
18) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.97 Pain Relevance 0.27
The effects of antidepressants on the expression of the Bdnf gene have been investigated extensively.
Gene_expression (expression) of Bdnf gene associated with antidepressant
19) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.51 Pain Relevance 0.61
Although BDNF is highly expressed in the brain, studies regarding the expression level of BDNF in the human brain of depressed subjects are limited.
Gene_expression (expressed) of BDNF in brain
20) Confidence 0.77 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.54 Pain Relevance 0.67

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