INT92677

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.25
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
astrocytes 6
fibroblast 6
thyroid 2
brain 2
corneas 2
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 25 100.00 Very High Very High Very High
Nerve growth factor 2 95.60 Very High Very High Very High
Spinal cord 246 94.64 High High
Somatostatin 1 91.84 High High
Inflammatory mediators 2 91.12 High High
medulla 120 88.60 High High
fibrosis 7 86.36 High High
metalloproteinase 16 82.08 Quite High
Chronic pancreatitis 1 80.12 Quite High
cva 3 66.76 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 6 99.34 Very High Very High Very High
Alzheimer's Dementia 2 98.62 Very High Very High Very High
Cancer 157 98.40 Very High Very High Very High
Malignant Neoplastic Disease 8 95.60 Very High Very High Very High
Primary Sclerosing Cholangitis 3 93.52 High High
INFLAMMATION 24 91.12 High High
Metastasis 28 89.76 High High
Fibrosis 8 89.04 High High
Repression 3 87.04 High High
Targeted Disruption 34 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a physical insult to the brain, astrocytes show increased FGF-2 immunoreactivity, which is the result of increased FGF-2 mRNA synthesis (Smith et al., 2001).
Positive_regulation (result) of Gene_expression (synthesis) of FGF-2 mRNA in astrocytes
1) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.11 Pain Relevance 0.10
Following a physical insult to the brain, astrocytes show increased FGF-2 immunoreactivity, which is the result of increased FGF-2 mRNA synthesis (Smith et al., 2001).
Positive_regulation (increased) of Gene_expression (synthesis) of FGF-2 mRNA in astrocytes
2) Confidence 0.46 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.11 Pain Relevance 0.10
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Positive_regulation (increase) of Gene_expression (expression) of FGF2 associated with malignant neoplastic disease
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.89 Pain Relevance 0
On day 70, the ECM composition was expanded by increased deposition of fibronectin, whereas connective tissue growth factor, fibroblast growth factor (FGF)-1, and FGF-2 mRNA expression levels were elevated in addition to TGF-beta1.
Positive_regulation (elevated) of Gene_expression (expression) of FGF-2 in fibroblast
4) Confidence 0.34 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.89 Pain Relevance 0.20
-amyloid precursor protein and the plaque-associated proteins [28]; They can induce the production of various growth and trophic factors, including fibroblast growth factor-2 (FGF-2) [29], transforming growth factor-?
Positive_regulation (induce) of Gene_expression (production) of fibroblast growth factor-2 in fibroblast associated with alzheimer's dementia
5) Confidence 0.33 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.27 Pain Relevance 0.40
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Positive_regulation (increase) of Gene_expression (expression) of bFGF
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06
As previous studies have shown, overexpression of VEGF, bFGF, PDGF, nitric oxide synthases, angiopoietin, and angiopoietin 2 were detected in alkali-burned corneas as early as 3 days [1].
Positive_regulation (overexpression) of Gene_expression (overexpression) of bFGF in corneas
7) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.68 Pain Relevance 0.07
-amyloid precursor protein and the plaque-associated proteins [28]; They can induce the production of various growth and trophic factors, including fibroblast growth factor-2 (FGF-2) [29], transforming growth factor-?
Positive_regulation (induce) of Gene_expression (production) of FGF-2 in fibroblast associated with alzheimer's dementia
8) Confidence 0.24 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.27 Pain Relevance 0.40
Following a physical insult to the brain, astrocytes show increased FGF-2 immunoreactivity, which is the result of increased FGF-2 mRNA synthesis (Smith et al., 2001).
Positive_regulation (result) of in brain Gene_expression (synthesis) of FGF-2 mRNA in astrocytes
9) Confidence 0.23 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.11 Pain Relevance 0.10
The PTTG1 and PBF expressions were upregulated in thyroid cancer [27,55,56] and were reported to stimulate bFGF expression [11].
Positive_regulation (stimulate) of Gene_expression (expression) of bFGF in thyroid associated with thyroid neoplasm
10) Confidence 0.21 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.42 Pain Relevance 0.03
In contrast, the levels of over 50 cytokines other cytokines, including bFGF, EGF, MCP-1, and MMP-9, remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of bFGF associated with cytokine
11) Confidence 0.17 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737623 Disease Relevance 0.07 Pain Relevance 0.10
Following a physical insult to the brain, astrocytes show increased FGF-2 immunoreactivity, which is the result of increased FGF-2 mRNA synthesis (Smith et al., 2001).
Positive_regulation (increased) of in brain Gene_expression (synthesis) of FGF-2 mRNA in astrocytes
12) Confidence 0.16 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.11 Pain Relevance 0.10

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