INT92678

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Context Info
Confidence 0.09
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 36
Disease Relevance 28.41
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
extracellular matrix 7
lung 2
stroma 1
Liver 1
cartilage 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 278 99.64 Very High Very High Very High
Chronic pancreatitis 1 99.56 Very High Very High Very High
metalloproteinase 74 98.28 Very High Very High Very High
Inflammation 499 97.20 Very High Very High Very High
Osteoarthritis 68 96.64 Very High Very High Very High
cytokine 123 87.16 High High
rheumatoid arthritis 29 83.76 Quite High
addiction 2 83.76 Quite High
Inflammatory response 71 78.56 Quite High
Multiple sclerosis 16 72.96 Quite High
Disease Link Frequency Relevance Heat
Asthma 570 100.00 Very High Very High Very High
Cerebral Malaria 196 100.00 Very High Very High Very High
Fibrosis 401 99.98 Very High Very High Very High
Injury 470 99.90 Very High Very High Very High
Apoptosis 403 99.90 Very High Very High Very High
Death 107 99.88 Very High Very High Very High
Cirrhosis 43 99.64 Very High Very High Very High
Pancreatitis 1 99.56 Very High Very High Very High
Ureteral Obstruction 36 99.44 Very High Very High Very High
Pulmonary Fibrosis 51 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data and our results confirm the critical role of aggrecanases in cartilage destruction and suggest that a controlled level of MMP-mediated aggrecanolysis may be needed for cartilage homeostasis, and possibly repair, as MMPs proteolysis can facilitate cell migration, regulate tissue architecture, release and activate ECM bound growth factors and signaling molecules49.
Positive_regulation (activate) of ECM in cartilage associated with metalloproteinase
1) Confidence 0.09 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.29 Pain Relevance 0.35
The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation of extracellular matrix (ECM).
Positive_regulation (accumulation) of ECM in pancreas associated with targeted disruption and chronic pancreatitis
2) Confidence 0.09 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.68 Pain Relevance 0.18
levels in the asthmatic airway may contribute to an increase in the ECM thereby augmenting the effects of airway remodeling.
Positive_regulation (increase) of ECM associated with asthma and airway remodeling
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.20 Pain Relevance 0.05
In particular, ECM protein deposition is increased in the lamina reticularis [34], resulting in basement membrane thickening [35].
Positive_regulation (increased) of ECM in thickening
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.06 Pain Relevance 0.04
To better understand the increased ECM deposition in animals treated with Marimastat, we analyzed hepatic MMP expression levels.
Positive_regulation (increased) of ECM
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.31 Pain Relevance 0.07
The accumulation of unremodeled ECM can result in impaired blood flow and oxygen delivery to the tissue, which leads to tissue hypoxia [14-16].
Positive_regulation (accumulation) of ECM in blood associated with hypoxia
6) Confidence 0.07 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.93 Pain Relevance 0.10
Pulmonary fibrosis is a major clinical problem characterized by accumulation of extracellular matrix (ECM) proteins, including collagen, fibronectin, proteoglycans, and elastin, leading to abnormal lung architecture and severe impairment of lung function [27].
Positive_regulation (accumulation) of ECM in lung associated with fibrosis and pulmonary fibrosis
7) Confidence 0.07 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.59 Pain Relevance 0.13
The ECM genes COL3A1, SPARC, BGN and NID1 were among those upregulated in IL11Ra-/- uterus compared to wild type.
Positive_regulation (upregulated) of ECM in uterus
8) Confidence 0.06 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
No effect of TLR2 deficiency on UUO-induced tubular injury and ECM accumulation
Positive_regulation (accumulation) of ECM associated with ureteral obstruction and injury
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.74 Pain Relevance 0.07
Nevertheless, here LT mRNA levels were not increased in ECM compared to uninfected controls.
Neg (not) Positive_regulation (increased) of ECM
10) Confidence 0.06 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.45 Pain Relevance 0.07
The gene expression of caspase 3 was not increased in ECM and was independent of rhEpo treatment, indicating that they are possibly not involved in the induction of apoptosis in ECM.
Neg (not) Positive_regulation (increased) of ECM associated with apoptosis
11) Confidence 0.06 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.78 Pain Relevance 0.11
When FBLN-1C was silenced by the AO in the asthma derived ECM, migration of either cell type was not altered (figure 11C).


Positive_regulation (derived) of ECM associated with asthma
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.14 Pain Relevance 0
not only increased FBLN-1 in asthma derived ASM cells, but also enhanced its deposition in the asthmatic ECM.
Positive_regulation (enhanced) of ECM associated with asthma
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.18 Pain Relevance 0.03
increased FBLN-1 deposition in the ECM from asthmatic ASM cells (P<0.01, figure 4B).
Positive_regulation (increased) of ECM associated with asthma
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.37 Pain Relevance 0.03
Fibulin-1 (FBLN-1), a secreted glycoprotein, assists in stabilizing the ECM.
Positive_regulation (stabilizing) of ECM
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.62 Pain Relevance 0.04
Elevated levels of nitrosylated ECM proteins were observed in the arthrofibrotic tissues (Figure 4B) compared with the OA tissues (Figure 4A).
Positive_regulation (levels) of ECM associated with osteoarthritis
16) Confidence 0.05 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.14 Pain Relevance 0.21
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Positive_regulation (upregulated) of ECM in ECM associated with injury
17) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.90 Pain Relevance 0.28
R affects T cell response to PbA induced ECM, and whether the effect is direct.
Spec (whether) Positive_regulation (induced) of ECM in T cell associated with cerebral malaria
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.83 Pain Relevance 0.04
dependent ECM proteins production.
Positive_regulation (dependent) of ECM
19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.45 Pain Relevance 0
dependent ECM regulatory proteins
Positive_regulation (dependent) of ECM
20) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0

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