INT92679

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 23
Disease Relevance 11.43
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
astrocyte 5
spinal cord 4
fibroblast 2
fat 1
brain 1
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 540 99.68 Very High Very High Very High
rheumatoid arthritis 203 99.62 Very High Very High Very High
cytokine 182 99.44 Very High Very High Very High
medulla 165 99.40 Very High Very High Very High
Arthritis 100 96.84 Very High Very High Very High
Spinal nerve ligature 11 93.04 High High
Inflammation 152 91.16 High High
Inflammatory response 37 90.96 High High
chemokine 44 88.20 High High
Peripheral nervous system 22 87.84 High High
Disease Link Frequency Relevance Heat
Injury 175 99.72 Very High Very High Very High
Rheumatoid Arthritis 203 99.62 Very High Very High Very High
Spinal Cord Injury 132 99.52 Very High Very High Very High
Wound Healing 43 98.64 Very High Very High Very High
Arthritis 96 96.84 Very High Very High Very High
Diabetes Mellitus 6 96.72 Very High Very High Very High
Synovitis 42 94.56 High High
Cancer 285 93.56 High High
Primary Sclerosing Cholangitis 3 93.52 High High
Cicatrix 12 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results presented here show that in response to mid trunk spinal cord transection, reactive astrocytes show increased FGF-2 especially in brainstem and the middle spinal cord region, anterior to the lesion site, suggesting that this growth factor participates in spinal cord recovery after complete transection.


Positive_regulation (increased) of FGF-2 in spinal cord associated with medulla and spinal cord
1) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.10 Pain Relevance 0.20
However, it has also been suggested that following injury the observed increase in FGF-2 would induce astrocyte proliferation and contribute to astrologists, which has a negative effect on regeneration (Gomez-Pinilla et al., 1995, 1997; Reilly and Kumari, 1996).
Positive_regulation (increase) of FGF-2 in astrocyte associated with injury
2) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.38 Pain Relevance 0.24
In conclusion, significant increase in FGF-2 immunoreactivity in reactive astrocytes (shown by GFAP immunoreactivity) was calculated in all regions during early regenerative process.
Positive_regulation (increase) of FGF-2 in astrocytes
3) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.13 Pain Relevance 0.20
Similarly, an increase in FGF-2 mRNA in the spinal cord precedes the observed increase in FGF-2 immunoreactivity (Moftah et al., 2008) suggesting that it might be responsible, at least in part, for the increase in astrocyte immunoreactivity marked by GFAP.
Positive_regulation (increase) of FGF-2 mRNA in astrocyte associated with spinal cord
4) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.12 Pain Relevance 0.11
Our results show that spinal cord injury triggers a significant increase in FGF-2 immunoreactivity in reactive astrocytes at sites of insult.
Positive_regulation (increase) of FGF-2 in spinal cord associated with spinal cord
5) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2990542 Disease Relevance 0.44 Pain Relevance 0.18
Furthermore, following a physical insult to brain or spinal cord, reactive astrocytes in the vicinity of the damage site show increased FGF-2 immunoreactivity (Gomez-Pinilla et al., 1992; Clarke et al., 2001; Smith et al., 2001).
Positive_regulation (increased) of FGF-2 in spinal cord associated with spinal cord
6) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.40 Pain Relevance 0.26
Similarly, an increase in FGF-2 mRNA in the spinal cord precedes the observed increase in FGF-2 immunoreactivity (Moftah et al., 2008) suggesting that it might be responsible, at least in part, for the increase in astrocyte immunoreactivity marked by GFAP.
Positive_regulation (increase) of FGF-2 in astrocyte associated with spinal cord
7) Confidence 0.69 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.12 Pain Relevance 0.13
This is consistent with Madiai et al. (2003) where increased FGF-2 immunoreactivity was as early as 1?
Positive_regulation (increased) of FGF-2
8) Confidence 0.50 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.23 Pain Relevance 0.49
Following physical insult of brain or spinal cord, reactive astrocytes show increased FGF-2 immunoreactivity.
Positive_regulation (increased) of FGF-2 in brain associated with spinal cord
9) Confidence 0.50 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2990542 Disease Relevance 0.40 Pain Relevance 0.16
The striking observation of the association of the increase of GFAP localization with the increase of FGF-2 immunoreactivity in all regions reveals that FGF-2 was primarily expressed in astrocytes, as previously demonstrated by Van der Wal et al. (1994).
Positive_regulation (increase) of FGF-2 in astrocytes
10) Confidence 0.50 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.11
Additionally, the present results support that of Zhang et al. (2000), who stated that significant up-regulation of FGF-2 occurred in the first week of spinal cord regeneration while its expression dramatically decreased in the third week.
Positive_regulation (up-regulation) of FGF-2 in spinal cord associated with spinal cord
11) Confidence 0.46 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.21 Pain Relevance 0.42
In the current study, we showed that treatment of fat grafts with EPO increased VEGF, bFGF, IGF-1, PDGF-BB and MMP-2 contents, as well as MVD in the fat grafts.
Positive_regulation (increased) of bFGF in fat
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.31 Pain Relevance 0
Upon passaging the cells did not persist in FGF2 alone, but required both EGF and FGF2 for continued proliferation.
Neg (not) Positive_regulation (persist) of FGF2
13) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.14 Pain Relevance 0
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Positive_regulation (increase) of bFGF
14) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06
In conclusion, our work demonstrates that radiation inhibits VEGF and FGF-2–induced angiogenesis through TGF-?
Positive_regulation (induced) of FGF-2
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.60 Pain Relevance 0.04
The cellular signaling mechanisms that regulate wound healing are complex and poorly understood, but recent findings suggest key roles for growth factors such as EGF, FGF2 and HGF, the cytokine TGF?
Positive_regulation (roles) of FGF2 in HGF associated with wound healing and cytokine
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 0.89 Pain Relevance 0.09
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Positive_regulation (elevated) of bFGF associated with rheumatoid arthritis
17) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.23 Pain Relevance 0.95
In addition to IL-6, FGF2 was increased more than three-fold that of matched controls by both BDNF and NGF.
Positive_regulation (increased) of FGF2
18) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.18 Pain Relevance 0.12
Previous reports have indicated that elevated FGF2 decreased both stromal cell derived factor-1 (SDF-1;CXCL12) mRNA and protein in vivo and also diminished the capacity of BMSC to support the expansion of peripheral blood derived stem cells[53].
Positive_regulation (elevated) of FGF2 in stem cells
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.17 Pain Relevance 0.12
Furthermore, Stat3-deficient myeloid derived suppressor cells fail to promote the formation of vessel-like structures in vitro, because induction of the pro-angiogenic factors VEGF, bFGF, IL-1?
Neg (fail) Positive_regulation (induction) of bFGF
20) Confidence 0.15 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.92 Pain Relevance 0.14

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