INT92680

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 59
Total Number 60
Disease Relevance 28.11
Pain Relevance 8.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
fibroblast 6
astrocytes 6
spinal cord 3
brain 2
fat 2
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 224 100.00 Very High Very High Very High
withdrawal 9 99.92 Very High Very High Very High
rheumatoid arthritis 157 99.60 Very High Very High Very High
Inflammation 151 99.46 Very High Very High Very High
Central nervous system 282 99.44 Very High Very High Very High
Hippocampus 29 99.32 Very High Very High Very High
Spinal cord 1038 99.12 Very High Very High Very High
Spinal nerve ligature 20 98.56 Very High Very High Very High
Peripheral nervous system 49 98.20 Very High Very High Very High
medulla 360 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lung Cancer 425 100.00 Very High Very High Very High
Corneal Neovascularization 79 99.98 Very High Very High Very High
Rheumatoid Arthritis 170 99.96 Very High Very High Very High
Status Epilepticus 2 99.96 Very High Very High Very High
Leukemia 142 99.80 Very High Very High Very High
Multiple Myeloma 120 99.64 Very High Very High Very High
INFLAMMATION 185 99.46 Very High Very High Very High
Cancer 1182 99.36 Very High Very High Very High
Thyroid Neoplasm 24 99.14 Very High Very High Very High
Osteochondroma 40 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our previous studies on FGF-2 mRNA expression revealed its short and long term up-regulation in Pleurodeles’ brainstem and distal spinal cord stump (SC3), the target for regenerated descending fibers to extend, in response to a mid-trunk spinal cord transection (Moftah et al., 2008).
Gene_expression (expression) of FGF-2 mRNA in spinal cord associated with medulla and spinal cord
1) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.24 Pain Relevance 0.46
Because astrocytes synthesize FGF-2 (Gomez-Pinilla et al., 1994) and express FGF receptors (FGFRs) -2 and -3 (Reuss et al., 2000), FGF-2 is a major candidate for the autocrine and/or paracrine regulation of astroglial cell differentiation, functions, and transition to a “reactive” phenotype.
Gene_expression (synthesize) of FGF-2 in astrocytes
2) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
Giampaoli et al. (2003) has shown that, temporally, FGF-2 is transiently expressed at early stages of regeneration and is no longer detectable by the medium-bud stage.
Gene_expression (expressed) of FGF-2
3) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.23 Pain Relevance 0.30
In order to understand FGF-2 expression dynamics during Pleurodeles CNS spontaneous regeneration in vivo, we studied its spatio-temporal localization in astrocyte populations using GFAP as a marker (Reeves et al., 1989) following spinal cord complete transection at the mid-trunk region.


Gene_expression (expression) of FGF-2 in trunk region associated with central nervous system and spinal cord
4) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.15 Pain Relevance 0.17
The striking observation of the association of the increase of GFAP localization with the increase of FGF-2 immunoreactivity in all regions reveals that FGF-2 was primarily expressed in astrocytes, as previously demonstrated by Van der Wal et al. (1994).
Gene_expression (expressed) of FGF-2 in astrocytes
5) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.11
In all regions, there was an obvious FGF-2 expression in GFAP-positive and -negative cells.
Gene_expression (expression) of FGF-2
6) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.12
The suggested expression of FGF-2 in reactive astrocytes and ependymal cells is consistent with numerous in vitro studies showing a key role for this growth factor in supporting proliferation of both embryonic and adult neural progenitors, in vitro (Shihabuddin et al., 1997; Moftah, 2007).
Gene_expression (expression) of FGF-2 in neural
7) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.22 Pain Relevance 0.19
Following a physical insult to the brain, astrocytes show increased FGF-2 immunoreactivity, which is the result of increased FGF-2 mRNA synthesis (Smith et al., 2001).
Gene_expression (synthesis) of FGF-2 mRNA in astrocytes
8) Confidence 0.77 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.11 Pain Relevance 0.10
This is known as the mechanisms of FGF-2 “export
Gene_expression (export) of FGF-2
9) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.09 Pain Relevance 0.13
A strong widespread colocalization was prominent between FGF-2 and GFAP immunoreactivity.


Gene_expression (prominent) of FGF-2
10) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
We finally assessed FGF-2 labeling in SC3 (Figure 5D).
Gene_expression (labeling) of FGF-2
11) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.19
This could be due to the amount of GFAP the cell produces and is regulated by FGF-2 presence, which refers to astrocytic activation (Reeves et al., 1989).
Gene_expression (presence) of FGF-2
12) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.07 Pain Relevance 0.07
Our results support these findings, where GFAP immunoreactivity was temporally associated with that of FGF-2 especially in SC1.
Gene_expression (especially) of FGF-2
13) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
Fibroblast growth factor-2 has been shown to induce both GFAP mRNA (Gomez-Pinilla et al., 1997) and astrocyte reactivity (Goddard et al., 2002).
Gene_expression (induce) of Fibroblast growth factor-2 in astrocyte
14) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.09 Pain Relevance 0.13
We provide evidence for FGF-2 distribution in regenerating ependymal tube cells.
Gene_expression (distribution) of FGF-2 in tube
15) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.28 Pain Relevance 0.19
We demonstrated a long-lasting up-regulation of FGF-2 mRNA expression in response to spinal transection at the mid trunk level, both in brainstem and in the spinal cord below injury.
Gene_expression (expression) of FGF-2 mRNA in spinal cord associated with medulla, injury and spinal cord
16) Confidence 0.60 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.40 Pain Relevance 0.33
The colocalization of FGF-2 and GFAP in the same cells (shown in orange, Figures 1A, B) suggests that the neuroglial cells lining the fourth ventricle are a major source of FGF-2 starting 1 week after spinal cord lesion.
Gene_expression (source) of FGF-2 in neuroglial cells associated with spinal cord
17) Confidence 0.60 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
Astrocytes, also a source of FGF-2, become reactive following both central and peripheral nervous system injury (Colburn et al., 1999; Clarke et al., 2001).
Gene_expression (source) of FGF-2 in Astrocytes associated with nervous system injury and peripheral nervous system
18) Confidence 0.60 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.48 Pain Relevance 0.30
During body spinal cord regeneration, a decreasing rostrocaudal gradient in FGF-2 mRNA expression along the brain stem-spinal cord axis was observed by Moftah et al. (2008) in intact Pleurodeles.
Gene_expression (expression) of FGF-2 mRNA in spinal cord associated with spinal cord
19) Confidence 0.60 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.37 Pain Relevance 0.29
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Gene_expression (expression) of bFGF
20) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06

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