INT92681

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.78
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
PSC 2
connective tissue 2
fibroblasts 2
connective 1
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 99.84 Very High Very High Very High
cytokine 63 98.84 Very High Very High Very High
Paracetamol 8 98.40 Very High Very High Very High
Chronic pancreatitis 10 98.00 Very High Very High Very High
ischemia 4 97.24 Very High Very High Very High
fibrosis 142 97.12 Very High Very High Very High
dexamethasone 10 96.40 Very High Very High Very High
chemokine 34 89.92 High High
cINOD 2 83.00 Quite High
alcohol 5 82.64 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 161 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 15 99.64 Very High Very High Very High
Stress 1 99.38 Very High Very High Very High
Necrosis 9 98.34 Very High Very High Very High
Hypersensitivity 3 98.28 Very High Very High Very High
Cancer 46 98.16 Very High Very High Very High
Pancreatitis 11 98.00 Very High Very High Very High
Apoptosis 117 97.80 Very High Very High Very High
Cv Unclassified Under Development 4 97.24 Very High Very High Very High
Atherosclerosis 71 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show the production of acetaldehyde and oxidant stress in mouse PSC are the cause of increased CCN2 mRNA and protein production after exposure of the cells to ethanol.
Positive_regulation (increased) of CCN2 in PSC associated with stress and primary sclerosing cholangitis
1) Confidence 0.69 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.48 Pain Relevance 0.03
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Positive_regulation (increased) of CTGF in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
2) Confidence 0.47 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.29 Pain Relevance 0.71
Activation of CTGF is associated with potent and persistent fibrotic changes in the tissues, which is typically represented as accumulation of the ECM components including collagens [24,25].
Positive_regulation (Activation) of CTGF associated with fibrosis
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.45 Pain Relevance 0.11
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (connective) of CTGF in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
4) Confidence 0.43 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.19 Pain Relevance 0.76
Downregulated genes included secreted frizzled-related protein and IGF-I, and upregulated genes included serum/GC-regulated kinase, connective-tissue growth factor, and lipocalin 2.
Positive_regulation (upregulated) of connective-tissue growth factor in connective
5) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.08 Pain Relevance 0.42
For example, gene expression profiling of normal human lung fibroblasts exposed to V2O5 in culture show increased levels of pro-fibrotic and angiogenic growth factors (PDGF, CTGF, HB-EGF, VEGF) as well as protective IFNs [20].
Positive_regulation (increased) of CTGF in fibroblasts associated with fibrosis
6) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.87 Pain Relevance 0.21
This gene list includes DUSP1, BTG2, IER2, PTGS2, NR4A1, AMD1, C20orf35, KLF4, RAB4A, KLF6, CTGF and GOLPH2.
Positive_regulation (includes) of CTGF
7) Confidence 0.30 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.94 Pain Relevance 0.17
may be expressed early to initiate matrix accumulation and induce CTGF, which is then persistently expressed as suggested in a mouse model of fibrosis [44], which may explain the lack of change in TGF-?
Positive_regulation (induce) of CTGF associated with fibrosis
8) Confidence 0.25 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 1.06 Pain Relevance 0.40
Immunohistology revealed increases in CTGF, CD44 and iNOS 6 months after meniscectomy.
Positive_regulation (increases) of CTGF
9) Confidence 0.25 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.93 Pain Relevance 0.33
Our data in cultured VSMCs show that statins upregulate the profibrotic mediator CTGF, the inhibitor of ECM degradation PAI-1, and collagen production, all of them regulated by Smads [7], [29], [30].
Positive_regulation (upregulate) of CTGF
10) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.47 Pain Relevance 0.03
-dependent CTGF and PAI-1 upregulation in a dose-dependent manner (Figure 7a).
Positive_regulation (upregulation) of CTGF
11) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0
On day 70, the ECM composition was expanded by increased deposition of fibronectin, whereas connective tissue growth factor, fibroblast growth factor (FGF)-1, and FGF-2 mRNA expression levels were elevated in addition to TGF-beta1.
Positive_regulation (elevated) of tissue growth factor in fibroblast
12) Confidence 0.17 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.90 Pain Relevance 0.20
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Positive_regulation (connective) of tissue growth factor in connective tissue associated with hypersensitivity and cytokine
13) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.13 Pain Relevance 0.10

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