INT92682

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 12.16
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
stellate cells 6
connective tissue 4
fibroblasts 4
epithelial cells 2
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 102 100.00 Very High Very High Very High
cytokine 73 100.00 Very High Very High Very High
Paracetamol 22 100.00 Very High Very High Very High
metalloproteinase 11 100.00 Very High Very High Very High
Inflammatory mediators 9 100.00 Very High Very High Very High
alcohol 12 95.44 Very High Very High Very High
antagonist 34 95.00 High High
fibrosis 77 94.64 High High
Chronic pancreatitis 12 93.44 High High
psoriasis 44 23.92 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 113 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 29 99.32 Very High Very High Very High
Targeted Disruption 51 99.16 Very High Very High Very High
Pseudomonas Infection 2 99.02 Very High Very High Very High
Clostridium Difficile Infection 2 98.40 Very High Very High Very High
Hypersensitivity 1 98.28 Very High Very High Very High
Apoptosis 297 97.80 Very High Very High Very High
Necrosis 15 95.08 Very High Very High Very High
Wound Healing 5 94.80 High High
Fibrosis 90 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Positive_regulation (mediated) of Gene_expression (expression) of CCN2 in stellate cells
1) Confidence 0.69 Published 2009 Journal Growth Factors Section Title Doc Link 19280452 Disease Relevance 0.64 Pain Relevance 0.27
CCN2 production, assessed by reverse-transcriptase polymerase chain reaction to measure CCN2 mRNA levels or by fluorescence activated cell sorting to assess CCN2 protein, was enhanced in a dose-dependent manner by ethanol or acetaldehyde.
Positive_regulation (enhanced) of Gene_expression (production) of CCN2
2) Confidence 0.60 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.64 Pain Relevance 0.25
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Positive_regulation (Acetaminophen-induced) of Gene_expression (expression) of CTGF associated with paracetamol
3) Confidence 0.49 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.90 Pain Relevance 0.84
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Positive_regulation (increased) of Gene_expression (Expression) of connective tissue growth factor in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
4) Confidence 0.47 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.11 Pain Relevance 0.83
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Positive_regulation (enhanced) of Gene_expression (production) of CTGF in PSC associated with primary sclerosing cholangitis
5) Confidence 0.47 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.28 Pain Relevance 0.69
As measured by quantitative real-time RT-PCR, the transcripts of Col1a2, Ctgf and SPARC showed increased expression in the fibroblasts from TBR1CA; Cre-ER mice injected with 4-OHT, in which Tgfbr1 was constitutively active, compared with those in the cells from TBR1CA; Cre-ER mice injected with oil (Figure 1).
Positive_regulation (increased) of Gene_expression (expression) of Ctgf in fibroblasts
6) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Positive_regulation (mediated) of Gene_expression (expression) of tissue growth factor in stellate cells
7) Confidence 0.44 Published 2009 Journal Growth Factors Section Title Doc Link 19280452 Disease Relevance 0.64 Pain Relevance 0.27
In NOS II knockout mice treated with acetaminophen, hepatic expression of TNF-alpha, as well as CTGF, was significantly increased compared to wild-type mice.
Positive_regulation (increased) of Gene_expression (expression) of CTGF associated with targeted disruption and paracetamol
8) Confidence 0.43 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.09 Pain Relevance 0.81
5Mol/L strongly increased CTGF production.
Positive_regulation (increased) of Gene_expression (production) of CTGF
9) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.18 Pain Relevance 0
The sections were also immunostained for CTGF and ?
Positive_regulation (sections) of Gene_expression (immunostained) of CTGF
10) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2956700 Disease Relevance 0.71 Pain Relevance 0
Our data in cultured VSMCs show that statins upregulate the profibrotic mediator CTGF, the inhibitor of ECM degradation PAI-1, and collagen production, all of them regulated by Smads [7], [29], [30].
Positive_regulation (upregulate) of Gene_expression (production) of CTGF
11) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.52 Pain Relevance 0.03
is the mediator of statin-induced CTGF overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CTGF
12) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.31 Pain Relevance 0
is the mediator of statin-induced CTGF overexpression.
Positive_regulation (mediator) of Gene_expression (overexpression) of CTGF
13) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.31 Pain Relevance 0
is the mediator of statin-induced CTGF overexpression.
Positive_regulation (induced) of Gene_expression (overexpression) of CTGF
14) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.31 Pain Relevance 0
On day 70, the ECM composition was expanded by increased deposition of fibronectin, whereas connective tissue growth factor, fibroblast growth factor (FGF)-1, and FGF-2 mRNA expression levels were elevated in addition to TGF-beta1.
Positive_regulation (elevated) of Gene_expression (expression) of tissue growth factor in fibroblast
15) Confidence 0.17 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.90 Pain Relevance 0.20
Bacterial lipid extracts derived from Yersinia, E. coli, Pseudomonas aeruginosa, Enterococcus faecalis or Staphylococcus aureus induce expression of CYR61 and CTGF in epithelial cells.
Positive_regulation (induce) of Gene_expression (expression) of CTGF in epithelial cells associated with pseudomonas infection
16) Confidence 0.14 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.74 Pain Relevance 0.12
LPA-induced CYR61 and CTGF mRNA expression requires Rho GTPases because it is abolished by Clostridium difficile toxin B, which inhibits RhoA and Rac-1.
Positive_regulation (requires) of Gene_expression (expression) of CTGF mRNA associated with clostridium difficile infection
17) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.74 Pain Relevance 0.11
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Positive_regulation (high) of Gene_expression (expression) of tissue growth factor in connective tissue associated with hypersensitivity and cytokine
18) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.13 Pain Relevance 0.10

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